| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4017609 | B | Chaperone activity at recombinant human C-terminal FLAG-tagged pendrin P123S mutant expressed in HEK293 cells assessed as increase in localization of protein mutant in plasma membrane after 12 hrs by DAPI staining based immunofluorescence microscopic analysis | Homo sapiens | 1 | ALA4017446 | cell-based format | Scientific Literature | |
| 2. | ALA4017615 | B | Chaperone activity at recombinant human C-terminal FLAG-tagged pendrin P123S mutant expressed in HEK293 cells assessed as translocation of mutant protein from cytoplasm to plasma membrane at 10 mM measured after 12 hrs by DAPI staining based immunofluorescence microscopic analysis | Homo sapiens | 1 | ALA4017446 | cell-based format | Scientific Literature | |
| 3. | ALA4017616 | B | Chaperone activity at recombinant human C-terminal FLAG-tagged pendrin P123S mutant expressed in HEK293 cells assessed as intracellular localization of mutant protein in plasma membrane at 10 mM incubated for 12 hrs followed by compound washout measured after 6 hrs by DAPI staining based immunofluorescence microscopic analysis | Homo sapiens | 3 | ALA4017446 | cell-based format | Scientific Literature | |
| 4. | ALA4017617 | B | Chaperone activity at recombinant human C-terminal FLAG-tagged pendrin P123S mutant expressed in HEK293 cells assessed as intracellular localization of mutant protein in plasma membrane at 0.1 mM incubated for 12 hrs followed by compound washout measured after 6 hrs by DAPI staining based immunofluorescence microscopic analysis | Homo sapiens | 1 | ALA4017446 | cell-based format | Scientific Literature | |
| 5. | ALA4017618 | B | Chaperone activity at recombinant human C-terminal FLAG-tagged pendrin P123S mutant expressed in HEK293 cells assessed as increase in localization of protein mutant in plasma membrane at 1 to 30 mM after 12 hrs by DAPI staining based immunofluorescence microscopic analysis | Homo sapiens | 17 | ALA4017446 | cell-based format | Scientific Literature | |
| 6. | ALA4017619 | B | Chaperone activity at recombinant human C-terminal FLAG-tagged pendrin P123S mutant expressed in HEK293 cells assessed as increase in localization of protein mutant in plasma membrane at 0.03 to 1 mM after 12 hrs by DAPI staining based immunofluorescence microscopic analysis | Homo sapiens | 1 | ALA4017446 | cell-based format | Scientific Literature | |
| 7. | ALA4017621 | B | Chaperone activity at recombinant human C-terminal FLAG-tagged pendrin P123S mutant expressed in HEK293 cells assessed as translocation of mutant protein from cytoplasm to plasma membrane at 3 mM measured after 12 hrs by DAPI staining based immunofluorescence microscopic analysis | Homo sapiens | 1 | ALA4017446 | cell-based format | Scientific Literature | |
| 8. | ALA4017622 | B | Chaperone activity at recombinant human C-terminal FLAG-tagged pendrin P123S mutant expressed in HEK293 cells assessed as translocation of mutant protein from cytoplasm to plasma membrane at 0.1 mM measured after 12 hrs by DAPI staining based immunofluorescence microscopic analysis | Homo sapiens | 1 | ALA4017446 | cell-based format | Scientific Literature | |
| 9. | ALA4017623 | B | Potency index, ratio of compound effect to salicylate effect for chaperone activity at recombinant human C-terminal FLAG-tagged pendrin P123S mutant expressed in HEK293 cells assessed as translocation of mutant protein from cytoplasm to plasma membrane | Homo sapiens | 1 | ALA4017446 | cell-based format | Scientific Literature | |
| 10. | ALA4017624 | B | Chaperone activity at recombinant human C-terminal FLAG-tagged pendrin P123S mutant expressed in HEK293 cells assessed as increase in fluorescence intensity ratio of plasma membrane to cytoplasm measured after 12 hrs by DAPI staining based immunofluorescence microscopic method | Homo sapiens | 4 | ALA4017446 | cell-based format | Scientific Literature | |
| 11. | ALA4017625 | B | Chaperone activity at recombinant human C-terminal FLAG-tagged pendrin P123S mutant expressed in HEK293 cells assessed as fluorescence intensity ratio of plasma membrane to cytoplasm at 10 mM measured after 12 hrs by DAPI staining based immunofluorescence microscopic method | Homo sapiens | 3 | ALA4017446 | cell-based format | Scientific Literature | |
| 12. | ALA4017626 | B | Chaperone activity at recombinant human C-terminal FLAG-tagged pendrin P123S mutant expressed in HEK293 cells assessed as fluorescence intensity ratio of plasma membrane to cytoplasm at 0.3 mM measured after 12 hrs by DAPI staining based immunofluorescence microscopic method | Homo sapiens | 1 | ALA4017446 | cell-based format | Scientific Literature | |
| 13. | ALA4017627 | B | Chaperone activity at recombinant human C-terminal FLAG-tagged pendrin P123S mutant expressed in HEK293 cells assessed as fluorescence intensity ratio of plasma membrane to cytoplasm at 0.1 mM measured after 12 hrs by DAPI staining based immunofluorescence microscopic method | Homo sapiens | 1 | ALA4017446 | cell-based format | Scientific Literature | |
| 14. | ALA4017628 | B | Chaperone activity at recombinant human C-terminal FLAG-tagged pendrin P123S mutant expressed in HEK293 cells assessed as intracellular localization of mutant protein in plasma membrane at 0.1 mM incubated for 12 hrs followed by compound washout measured after 12 hrs by DAPI staining based immunofluorescence microscopic analysis | Homo sapiens | 1 | ALA4017446 | cell-based format | Scientific Literature | |
| 15. | ALA4017629 | B | Chaperone activity at recombinant human C-terminal FLAG-tagged pendrin P123S mutant expressed in HEK293 cells assessed as intracellular localization of mutant protein in plasma membrane at 10 mM incubated for 12 hrs followed by compound washout measured after 12 hrs by DAPI staining based immunofluorescence microscopic analysis | Homo sapiens | 1 | ALA4017446 | cell-based format | Scientific Literature | |
| 16. | ALA4017630 | B | Chaperone activity at recombinant human C-terminal FLAG-tagged pendrin P123S mutant expressed in HEK293 cells assessed as translocation of mutant protein from cytoplasm to plasma membrane at 1 to 10 mM measured after 12 hrs by DAPI staining based immunofluorescence microscopic analysis | Homo sapiens | 1 | ALA4017446 | cell-based format | Scientific Literature | |
| 17. | ALA4350055 | B | Inhibition of human PDS stably expressed in FRT cells coexpressing EYFP-H148Q/I152L/F46L assessed as reduction in I-/Cl- exchange incubated for 10 mins by fluorescence based assay | Homo sapiens | 1 | ALA4346737 | cell-based format | Scientific Literature | |
| 18. | ALA4418131 | B | Inhibition of human pendrin expressed in FRT cells co-expressing EYFP-HIF assessed as reduction in pendrin-mediated anion exchange at 100 uM incubated for 10 mins by pH-sensitive fluorescent probe BCECF-AM based fluorescence assay relative to control | Homo sapiens | 1 | ALA4417636 | cell-based format | Patent Bioactivity Data | |
| 19. | ALA4418132 | B | Inhibition of human pendrin expressed in FRT cells co-expressing EYFP-HIF assessed as reduction in pendrin-mediated anion exchange at 25 uM incubated for 10 mins by pH-sensitive fluorescent probe BCECF-AM based fluorescence assay relative to control | Homo sapiens | 22 | ALA4417636 | cell-based format | Patent Bioactivity Data | |
| 20. | ALA4418133 | B | Inhibition of human pendrin expressed in FRT cells co-expressing EYFP-HIF assessed as reduction in pendrin-mediated C17SCN(-) exchange incubated for 10 mins by pH-sensitive fluorescent probe BCECF-AM based fluorescence assay relative to control | Homo sapiens | 2 | ALA4417636 | cell-based format | Patent Bioactivity Data |
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