# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4309278 | B | Activation of GPX4 in MEF assessed as increase in oxidized glutathione-mediated oxidation of NADPH to NADP+ using tert-butyl hydroperoxide as substrate preincubated for 5 mins followed by substrate addition measured for 6 mins by glutathione reductase enzyme coupled fluorescence assay | Mus musculus | 2 | ALA4308834 | cell-based format | Scientific Literature | |
2. | ALA4309281 | B | Activation of GPX4 in MEF assessed as increase in oxidized protection against CHOOH-induced cell death at 200 uM | Mus musculus | 2 | ALA4308834 | cell-based format | Scientific Literature | |
3. | ALA4816987 | F | In vivo inhibition of GPX4 in human MCF7 cells xenografted in BALB/c mouse at 25 to 50 mg/kg, ip administered once for 17 days by immunofluorescence analysis | Mus musculus | 1 | ALA4813989 | organism-based format | Scientific Literature |