| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4316664 | A | Inhibition of UGT1A in rat hepatocytes preincubated for 2 mins followed by UDPGA addition measured after 45 mins by HPLC analysis | Rattus norvegicus | 4 | cell-based format | Scientific Literature | ||
| 2. | ALA4316676 | A | Inhibition of UGT1A in rat hepatocytes assessed as decrease in bilirubin monoglucuronide level at 10 uM after 45 mins in presence of UDPGA by HPLC analysis | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
| 3. | ALA4316677 | A | Inhibition of UGT1A in rat hepatocytes assessed as decrease in bilirubin monoglucuronide level at 75 uM preincubated for 2 mins followed by UDPGA addition measured after 45 mins by HPLC analysis | Rattus norvegicus | 2 | cell-based format | Scientific Literature | ||
| 4. | ALA4316678 | A | Inhibition of UGT1A in rat hepatocytes assessed as decrease in bilirubin diglucuronide level at 75 uM preincubated for 2 mins followed by UDPGA addition measured after 45 mins by HPLC analysis | Rattus norvegicus | 2 | cell-based format | Scientific Literature | ||
| 5. | ALA4316679 | A | Inhibition of UGT1A in rat hepatocytes assessed as increase in unconjugated bilirubin level at 75 uM preincubated for 2 mins followed by UDPGA addition measured after 45 mins by HPLC analysis | Rattus norvegicus | 2 | cell-based format | Scientific Literature | ||
| 6. | ALA4316685 | A | Inhibition of UGT1A in rat hepatocytes assessed as decrease in bilirubin diglucuronide level at 10 uM preincubated for 2 mins followed by UDPGA addition measured after 45 mins by HPLC analysis relative to control | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
| 7. | ALA4316686 | A | Inhibition of UGT1A in rat hepatocytes assessed as decrease in bilirubin monoglucuronide level at 10 uM preincubated for 2 mins followed by UDPGA addition measured after 45 mins by HPLC analysis relative to control | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
| 8. | ALA4316687 | A | Inhibition of UGT1A in rat hepatocytes assessed as decrease in bilirubin diglucuronide level at 10 uM after 45 mins in presence of UDPGA by HPLC analysis | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
| 9. | ALA4392453 | A | Inhibition of recombinant rat UGT1A1 using beta-estradiol as substrate preincubated for 5 mins followed by substrate addition and measured after 40 mins by LC-MS/MS analysis | Rattus norvegicus | 2 | single protein format | Scientific Literature | ||
| 10. | ALA4392455 | A | Inhibition of UGT1A1 in rat liver microsomes using beta-estradiol as substrate preincubated for 5 mins followed by substrate addition and measured after 40 mins by LC-MS/MS analysis | Rattus norvegicus | 2 | microsome format | Scientific Literature | ||
| 11. | ALA4392458 | A | Ratio of test compound IC50 to atazanavir IC50 for recombinant rat UGT1A1 | Rattus norvegicus | 1 | single protein format | Scientific Literature | ||
| 12. | ALA4392460 | A | Ratio of test compound IC50 to atazanavir IC50 for UGT1A1 in rat liver microsomes | Rattus norvegicus | 1 | microsome format | Scientific Literature | ||
| 13. | ALA4481177 | A | Drug metabolism in rat hepatocytes assessed as UGT1A1-mediated acylglucuronide metabolite formation at 10 uM after 4 hrs by HPLC-UV and mass spectrometric analysis | Rattus norvegicus | 3 | cell-based format | Scientific Literature |
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