| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4422579 | B | Inhibition of StrepTag-tagged human SARM1 TIR (561 to 724 residues) expressed in HEK293T cells assessed as reduction in NADase activity in presence of NAD+ incubated for 60 mins by HPLC analysis | Homo sapiens | 26 | ALA4421736 | cell-based format | Patent Bioactivity Data | |
| 2. | ALA4422580 | B | Inhibition of StrepTag-tagged human SARM1 TIR (561 to 724 residues) expressed in HEK293T cells in presence of NAD+ incubated for 60 mins by chemiluminescence based NAD+ Glo assay | Homo sapiens | 2 | ALA4421736 | cell-based format | Patent Bioactivity Data | |
| 3. | ALA4422581 | B | Inhibition of StrepTag-tagged human SARM1 TIR (561 to 724 residues) expressed in HEK293T cells assessed as reduction in NADase activity at 5 uM in presence of NAD+ incubated for 60 mins by LC-MS/MS analysis | Homo sapiens | 2 | ALA4421736 | cell-based format | Patent Bioactivity Data | |
| 4. | ALA4422584 | B | Inhibition of StrepTag-tagged human SARM1 TIR (561 to 724 residues) expressed in HEK293T cells assessed as reduction in NADase activity at 1 mM in presence of NAD+ incubated for 60 mins by HPLC analysis | Homo sapiens | 2 | ALA4421736 | cell-based format | Patent Bioactivity Data | |
| 5. | ALA4422585 | B | Substrate activity at StrepTag-tagged human SARM1 TIR (561 to 724 residues) expressed in HEK293T cells assessed as increase in in NADase activity in presence of NAD+ incubated for 60 mins by HPLC analysis | Homo sapiens | 9 | ALA4421736 | cell-based format | Patent Bioactivity Data | |
| 6. | ALA4422586 | B | Substrate activity at StrepTag-tagged human SARM1 TIR (561 to 724 residues) expressed in HEK293T cells assessed as increase in in NADase activity at 100 uM in presence of NAD+ incubated for 60 mins by HPLC analysis | Homo sapiens | 1 | ALA4421736 | cell-based format | Patent Bioactivity Data | |
| 7. | ALA4422587 | B | Inhibition of StrepTag-tagged human SARM1 TIR (561 to 724 residues) expressed in HEK293T cells assessed as reduction in NADase activity at 5 uM in presence of NAD+ incubated for 60 mins by HPLC analysis | Homo sapiens | 6 | ALA4421736 | cell-based format | Patent Bioactivity Data | |
| 8. | ALA4422588 | B | Inhibition of StrepTag-tagged human SARM1 TIR (561 to 724 residues) expressed in HEK293T cells assessed as reduction in NADase activity at 10 uM in presence of NAD+ incubated for 60 mins by HPLC analysis relative to control | Homo sapiens | 1 | ALA4421736 | cell-based format | Patent Bioactivity Data | |
| 9. | ALA4422589 | B | Inhibition of StrepTag-tagged human SARM1 TIR (561 to 724 residues) expressed in HEK293T cells assessed as reduction in NADase activity at 30 uM in presence of NAD+ incubated for 60 mins by HPLC analysis relative to control | Homo sapiens | 1 | ALA4421736 | cell-based format | Patent Bioactivity Data | |
| 10. | ALA4422590 | B | Inhibition of StrepTag-tagged human SARM1 TIR (561 to 724 residues) expressed in NRK1-HEK293T cells assessed as reduction in NADase activity by measuring NAD depletion pre-incubated up to 120 mins before NAD+ addition and further incubated for 60 mins by HPLC analysis | Homo sapiens | 6 | ALA4421736 | cell-based format | Patent Bioactivity Data | |
| 11. | ALA4422591 | B | Inhibition of StrepTag-tagged human SARM1 TIR (561 to 724 residues) expressed in NRK1-HEK293T cells assessed as reduction in NADase activity by measuring maximal ADPR conversion pre-incubated up to 120 mins before NAD+ addition and further incubated for 60 mins by HPLC analysis | Homo sapiens | 4 | ALA4421736 | cell-based format | Patent Bioactivity Data | |
| 12. | ALA4422592 | B | Inhibition of StrepTag-tagged human SARM1 TIR (561 to 724 residues) expressed in NRK1-HEK293T cells assessed as reduction in NADase activity by measuring NAD consumption at 150 uM pre-incubated up to 120 mins before NAD+ addition and further incubated for 60 mins by HPLC analysis relative to control | Homo sapiens | 6 | ALA4421736 | cell-based format | Patent Bioactivity Data | |
| 13. | ALA4422593 | B | Inhibition of StrepTag-tagged human SARM1 TIR (561 to 724 residues) expressed in NRK1-HEK293T cells assessed as reduction in NADase activity by measuring ADPR production at 150 uM pre-incubated up to 120 mins before NAD+ addition and further incubated for 60 mins by HPLC analysis | Homo sapiens | 6 | ALA4421736 | cell-based format | Patent Bioactivity Data | |
| 14. | ALA4729678 | B | Inhibition of recombinant human SARM1 TIR domain (561 to 724 residues) expressed in Escherichia coli C43 (DE3) cells lysates using ENAD as substrate at 25 uM preincubated for 20 mins followed by ENAD addition and measured after 1 hr relative to control | Homo sapiens | 4 | ALA4725376 | subcellular format | Scientific Literature | |
| 15. | ALA4729679 | B | Inhibition of recombinant human SARM1 TIR domain (561 to 724 residues) expressed in Escherichia coli C43 (DE3) cells lysates using ENAD as substrate preincubated for 20 mins followed by ENAD addition and measured at 15 sec interval for 15 mins | Homo sapiens | 4 | ALA4725376 | subcellular format | Scientific Literature | |
| 16. | ALA4729680 | B | Noncompetitive inhibition of recombinant human SARM1 TIR domain (561 to 724 residues) expressed in Escherichia coli C43 (DE3) cells lysates assessed as EADPR formation using ENAD as substrate preincubated for 20 mins followed by ENAD addition and measured at 15 sec interval for 1 hr | Homo sapiens | 3 | ALA4725376 | subcellular format | Scientific Literature | |
| 17. | ALA4729681 | B | Competitive inhibition of recombinant human SARM1 TIR domain (561 to 724 residues) expressed in Escherichia coli C43 (DE3) cells lysates assessed as EADPR formation using ENAD as substrate preincubated for 20 mins followed by ENAD addition and measured at 15 sec interval for 1 hr | Homo sapiens | 1 | ALA4725376 | subcellular format | Scientific Literature | |
| 18. | ALA4729682 | B | Inhibition of recombinant human SARM1 SAM1-2-TIR domains (412 to 724 residues) expressed in Escherichia coli C43 (DE3) cells lysates using ENAD as substrate preincubated for 20 mins followed by ENAD addition and measured at 15 sec interval for 1 hr | Homo sapiens | 1 | ALA4725376 | subcellular format | Scientific Literature | |
| 19. | ALA4729683 | B | Inhibition of recombinant human SARM1 SAM1-2-TIR domains (412 to 724 residues) expressed in Expi293 cells lysates using ENAD as substrate preincubated for 20 mins followed by ENAD addition and measured at 15 sec interval for 1 hr | Homo sapiens | 1 | ALA4725376 | subcellular format | Scientific Literature | |
| 20. | ALA4729684 | B | Inhibition of purified human SARM1 TIR domain (561 to 724 residues) using ENAD as substrate preincubated for 20 mins followed by ENAD addition and measured at 15 sec interval for 1 hr | Homo sapiens | 1 | ALA4725376 | single protein format | Scientific Literature |
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