# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4420878 | B | Inhibition of Dusp6 in (Tg(Dusp6:d2EGFP)pt6) transgenic Zebrafish assessed as activation of FGF signaling after 2 hrs by d2EGFP fluorescence based assay | Danio rerio | 1 | single protein format | Patent Bioactivity Data | ||
2. | ALA4420879 | B | Inhibition of Dusp6 in (Tg(Dusp6:d2EGFP)pt6) transgenic Zebrafish assessed as activation of FGF signaling by measuring increase in ntl expression within notochord and tail bud at 6-somite stage at 10 to 20 uM dosed prior to gastrulation by whole mount in situ hybridization assay | Danio rerio | 1 | organism-based format | Patent Bioactivity Data | ||
3. | ALA4420880 | B | Inhibition of Dusp6 in (Tg(Dusp6:d2EGFP)pt6) transgenic Zebrafish assessed as activation of FGF signaling by measuring increase in dusp6 expression at 10 to 20 uM dosed 1 to 10-somite stage by whole mount in situ hybridization assay | Danio rerio | 1 | organism-based format | Patent Bioactivity Data | ||
4. | ALA4420881 | B | Inhibition of Dusp6 in (Tg(Dusp6:d2EGFP)pt6) transgenic Zebrafish assessed as activation of FGF signaling by measuring expansion of prospective mid-hindbrain boundary at 10 to 20 uM dosed 1 to 10-somite stage by whole mount in situ hybridization assay | Danio rerio | 1 | organism-based format | Patent Bioactivity Data | ||
5. | ALA4420882 | B | Inhibition of Dusp6 in (Tg(Dusp6:d2EGFP)pt6) transgenic Zebrafish assessed as activation of FGF signaling by measuring increase in eng3 expression at 10 to 20 uM dosed 1 to 10-somite stage by whole mount in situ hybridization assay | Danio rerio | 1 | organism-based format | Patent Bioactivity Data | ||
6. | ALA4420883 | B | Inhibition of Dusp6 in (Tg(Dusp6:d2EGFP)pt6) transgenic Zebrafish assessed as activation of FGF signaling by measuring expansion of rhombomere-4 and tail bud at 10 to 20 uM dosed 1 to 10-somite stage by whole mount in situ hybridization assay | Danio rerio | 1 | organism-based format | Patent Bioactivity Data | ||
7. | ALA4420884 | B | Inhibition of Dusp6 in (Tg(Dusp6:d2EGFP)pt6) transgenic Zebrafish assessed as activation of FGF signaling by measuring increase in krox20 expression at 10 to 20 uM dosed 1 to 10-somite stage by whole mount in situ hybridization assay | Danio rerio | 1 | organism-based format | Patent Bioactivity Data | ||
8. | ALA4420885 | B | Inhibition of Dusp6 in (Tg(Dusp6:d2EGFP)pt6) transgenic Zebrafish assessed as activation of FGF signaling by measuring increase in sef expression at 10 to 20 uM by semi-quantitative RT-PCR analysis | Danio rerio | 1 | assay format | Patent Bioactivity Data | ||
9. | ALA4420886 | B | Inhibition of Dusp6 in (Tg(Dusp6:d2EGFP)pt6) transgenic Zebrafish assessed as activation of FGF signaling by measuring increase in spry4 expression at 10 to 20 uM by semi-quantitative RT-PCR analysis | Danio rerio | 1 | assay format | Patent Bioactivity Data | ||
10. | ALA4420887 | B | Inhibition of Dusp6 in (Tg(Dusp6:d2EGFP)pt6) transgenic Zebrafish assessed as activation of FGF signaling at 5 uM by d2EGFP fluorescence based assay | Danio rerio | 1 | single protein format | Patent Bioactivity Data | ||
11. | ALA4420888 | B | Inhibition of Dusp6 in (Tg(Dusp6:d2EGFP)pt6) transgenic Zebrafish assessed as activation of FGF signaling at 20 uM by d2EGFP fluorescence based assay | Danio rerio | 2 | single protein format | Patent Bioactivity Data | ||
12. | ALA4420889 | B | Inhibition of Dusp6 in (Tg(Dusp6:d2EGFP);ace mutant) transgenic Zebrafish assessed as activation of FGF signaling in mid-hindbrain boundary by d2EGFP fluorescence based assay | Danio rerio | 1 | single protein format | Patent Bioactivity Data | ||
13. | ALA4420890 | B | Inhibition of Dusp6 in Zebrafish 1-cell stage embryos assessed as rescue of Zebrafish dusp6-mediated suppression of sef expression at 5 uM | Danio rerio | 1 | assay format | Patent Bioactivity Data | ||
14. | ALA4420905 | B | Inhibition of Dusp6 in Zebrafish assessed as assessed as activation of FGF signaling by measuring induction of caudal expansion of gata4 in ALPM relative to control | Danio rerio | 1 | single protein format | Patent Bioactivity Data | ||
15. | ALA4420906 | B | Inhibition of Dusp6 in Zebrafish assessed as assessed as activation of FGF signaling by measuring nkX2.5 expression relative to control | Danio rerio | 1 | assay format | Patent Bioactivity Data | ||
16. | ALA4420907 | B | Inhibition of Dusp6 in Zebrafish assessed as assessed as activation of FGF signaling by measuring Scl/tall expression relative to control | Danio rerio | 1 | assay format | Patent Bioactivity Data | ||
17. | ALA4420908 | B | Inhibition of Dusp6 in Zebrafish assessed as assessed as activation of FGF signaling by measuring reduction in ETSRP expression relative to control | Danio rerio | 1 | assay format | Patent Bioactivity Data | ||
18. | ALA4420909 | B | Inhibition of Dusp6 in Zebrafish assessed as assessed as activation of FGF signaling by measuring expansion of cardiac hand2 expression at 10-somite stage relative to control | Danio rerio | 1 | assay format | Patent Bioactivity Data | ||
19. | ALA4420910 | B | Inhibition of Dusp6 in Zebrafish assessed as assessed as activation of FGF signaling by measuring cmlc2 expression at 18-somite stage relative to control | Danio rerio | 1 | assay format | Patent Bioactivity Data | ||
20. | ALA4420917 | B | Inhibition of Dusp6 in (Tg(Dusp6:d2EGFP)pt6) transgenic Zebrafish assessed as activation of FGF signaling treated at 24 hours post fertilization and measured after 6 hrs post dose by d2EGFP fluorescence based assay | Danio rerio | 5 | single protein format | Patent Bioactivity Data |