| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4406418 | B | Inhibition of CYP4Z1 (unknown origin) in human HepG2 cell membranes transduced with lentiviral vector using luciferin-benzyl ether as substrate preincubated with NADPH for 30 mins followed by substrate addition and measured after 10 mins by P450-glo luciferase based luminescence assay | Homo sapiens | 10 | ALA4402606 | cell-based format | Scientific Literature | |
| 2. | ALA4406419 | B | Inhibition of CYP4Z1 (unknown origin) in human HepG2 cell membranes transduced with lentiviral vector using luciferin-benzyl ether as substrate incubated for 5 mins followed by NADPH addition and measured after 20 mins by P450-glo luciferase based luminescence assay | Homo sapiens | 10 | ALA4402606 | cell-based format | Scientific Literature | |
| 3. | ALA4406420 | B | Ratio of IC50 for inhibition of CYP4Z1 (unknown origin) in human HepG2 cell membranes transduced with lentiviral vector using luciferin-benzyl ether as substrate incubated for 5 mins followed by NADPH addition and measured after 20 mins to IC50 for inhibition of CYP4Z1 (unknown origin) in human HepG2 cell membranes transduced with lentiviral vector using luciferin-benzyl ether as substrate preincubated with NADPH for 30 mins followed by substrate addition and measured after 10 mins by P450-glo luciferase based luminescence assay | Homo sapiens | 10 | ALA4402606 | cell-based format | Scientific Literature | |
| 4. | ALA4406481 | B | Inhibition of CYP4Z1 (unknown origin) in human HepG2 cell membranes transduced with lentiviral vector using luciferin-benzyl ether as substrate preincubated for 5 mins with NADPH followed by substrate addition and measured after 10 mins by LC-MS/M S analysis | Homo sapiens | 1 | ALA4402606 | cell-based format | Scientific Literature | |
| 5. | ALA4406482 | B | Inhibition of CYP4Z1 (unknown origin) in human HepG2 cell membranes transduced with lentiviral vector assessed as inactivation constant using luciferin-benzyl ether as substrate preincubated for 5 mins with NADPH followed by substrate addition and measured after 10 mins by LC-MS/MS analysis | Homo sapiens | 1 | ALA4402606 | cell-based format | Scientific Literature | |
| 6. | ALA4406483 | B | Inhibition of CYP4Z1 (unknown origin) in human HepG2 cell membranes transduced with lentiviral vector using luciferin-benzyl ether as substrate incubated for 5 mins followed by NADPH addition by LC-MS/MS analysis | Homo sapiens | 1 | ALA4402606 | cell-based format | Scientific Literature | |
| 7. | ALA4406486 | B | Irreversible inhibition of CYP4Z1 (unknown origin) in human HepG2 cell membranes transduced with lentiviral vector at 3 uM using Luc-BE as substrate preincubated for 5 mins before NADPH addition for 15 mins and followed by substrate addition and measured after overnight post dialysis | Homo sapiens | 1 | ALA4402606 | cell-based format | Scientific Literature | |
| 8. | ALA4406487 | B | Inhibition of CYP4Z1 (unknown origin) in human HepG2 cell membranes transduced with lentiviral vector assessed as partition ratio by measuring number of molecules required for enzyme inactivation up to 50 uM pre incubated for 5 mins before NADPH addition for 45 mins followed by substrate addition and measured after 10 mins by P450-glo luciferase reagent based luminescence assay | Homo sapiens | 1 | ALA4402606 | cell-based format | Scientific Literature | |
| 9. | ALA4406488 | B | Inhibition of CYP4Z1 (unknown origin) in human HepG2 cell membranes transduced with lentiviral vector at 3 uM using Luc-BE as substrate preincubated for 5 mins before NADPH addition for 15 mins and followed by substrate addition and measured after 10 mins in presence of GSH by P450-glo luciferase reagent based luminescence assay | Homo sapiens | 1 | ALA4402606 | cell-based format | Scientific Literature | |
| 10. | ALA4406489 | B | Inhibition of CYP4Z1 (unknown origin) in human HepG2 cell membranes transduced with lentiviral vector at 3 uM using Luc-BE as substrate preincubated for 5 mins before NADPH addition for 15 mins and followed by substrate addition and measured after 10 mins in presence of N-acetyl-lysine by P450-glo luciferase reagent based luminescence assay | Homo sapiens | 1 | ALA4402606 | cell-based format | Scientific Literature | |
| 11. | ALA4406490 | B | Inhibition of CYP4Z1 (unknown origin) in human HepG2 cell membranes transduced with lentiviral vector at 3 uM using Luc-BE as substrate preincubated for 5 mins before NADPH addition for 15 mins and followed by substrate addition and measured after 10 mins in presence of methoxyamine by P450-glo luciferase reagent based luminescence assay | Homo sapiens | 1 | ALA4402606 | cell-based format | Scientific Literature | |
| 12. | ALA4406491 | B | Inhibition of CYP4Z1 (unknown origin) in human HepG2 cell membranes transduced with lentiviral vector at 3 uM using Luc-BE as substrate preincubated for 5 mins before NADPH addition for 15 mins and followed by substrate addition and measured after 10 mins in presence of NAC by P450-glo luciferase reagent based luminescence assay | Homo sapiens | 1 | ALA4402606 | cell-based format | Scientific Literature | |
| 13. | ALA4406492 | B | Inhibition of CYP4Z1 (unknown origin) in human HepG2 cell membranes transduced with lentiviral vector at 3 uM using Luc-BE as substrate preincubated for 5 mins before NADPH addition for 15 mins and followed by substrate addition and measured after 10 mins in presence of semicarbazide by P450-glo luciferase reagent based luminescence assay | Homo sapiens | 1 | ALA4402606 | cell-based format | Scientific Literature | |
| 14. | ALA4406493 | B | Inhibition of CYP4Z1 (unknown origin) in human HepG2 cell membranes transduced with lentiviral vector at 3 uM using Luc-BE as substrate preincubated for 5 mins before NADPH addition for 15 mins and followed by substrate addition and measured after 10 mins in presence of KCN by P450-glo luciferase reagent based luminescence assay | Homo sapiens | 1 | ALA4402606 | cell-based format | Scientific Literature | |
| 15. | ALA4406494 | B | Inhibition of CYP4Z1 (unknown origin) in human HepG2 cell membranes transduced with lentiviral vector at 3 uM using Luc-BE as substrate preincubated for 5 mins before NADPH addition for 15 mins and followed by substrate addition and measured after 10 mins in presence of SOD by P450-glo luciferase reagent based luminescence assay | Homo sapiens | 1 | ALA4402606 | cell-based format | Scientific Literature | |
| 16. | ALA4406495 | B | Inhibition of CYP4Z1 (unknown origin) in human HepG2 cell membranes transduced with lentiviral vector at 3 uM using Luc-BE as substrate preincubated for 5 mins before NADPH addition for 15 mins and followed by substrate addition and measured after 10 mins in presence of catalase by P450-glo luciferase reagent based luminescence assay | Homo sapiens | 1 | ALA4402606 | cell-based format | Scientific Literature | |
| 17. | ALA4406496 | B | Inhibition of CYP4Z1 (unknown origin) expressed in human T47D cells using lentivirus expression system assessed as inhibition of 14,15-EET metabolite formation at 1 uM using arachidonic acid as substrate after 2 hrs by UPLC-MS/MS analysis relative to control | Homo sapiens | 1 | ALA4402606 | cell-based format | Scientific Literature | |
| 18. | ALA4406497 | B | Inhibition of CYP4Z1 (unknown origin) expressed in human T47D cells using lentivirus expression system assessed as inhibition of 14,15-EET metabolite formation at 3 uM using arachidonic acid as substrate after 2 hrs by UPLC-MS/MS analysis relative to control | Homo sapiens | 1 | ALA4402606 | cell-based format | Scientific Literature | |
| 19. | ALA4406498 | B | Inhibition of CYP4Z1 (unknown origin) expressed in human T47D cells using lentivirus expression system assessed as inhibition of 14,15-EET metabolite formation at 1 uM using arachidonic acid as substrate preincubated for 24 hrs followed by substrate addition and measured after 2 hrs by UPLC-MS/MS analysis relative to control | Homo sapiens | 1 | ALA4402606 | cell-based format | Scientific Literature | |
| 20. | ALA4406499 | B | Inhibition of CYP4Z1 (unknown origin) expressed in human T47D cells using lentivirus expression system assessed as inhibition of 14,15-EET metabolite formation at 3 uM using arachidonic acid as substrate preincubated for 24 hrs followed by substrate addition and measured after 2 hrs by UPLC-MS/MS analysis relative to control | Homo sapiens | 1 | ALA4402606 | cell-based format | Scientific Literature |
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