| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4325121 | B | Agonist activity at STING in human THP1 cells assessed as stimulation of IRF3 pathway measured after 20 hrs by luciferase reporter gene assay | Homo sapiens | 48 | ALA4321869 | cell-based format | Scientific Literature | |
| 2. | ALA4325125 | B | Inhibition of anti 6His antibody-labeled terbium cryptate binding to human wild-type full-length 6His-tagged d2-labeled STING measured after 4 hrs by HTRF assay | Homo sapiens | 6 | ALA4321869 | single protein format | Scientific Literature | |
| 3. | ALA4325126 | B | Agonist activity at STING in human PBMC cells assessed as increase in IFNbeta release measured after 4 hrs by ELISA | Homo sapiens | 3 | ALA4321869 | cell-based format | Scientific Literature | |
| 4. | ALA4325127 | B | Agonist activity at STING in human PBMC cells assessed as increase in IFNbeta release at 1.39 to 139 uM measured after 4 hrs by ELISA | Homo sapiens | 1 | ALA4321869 | cell-based format | Scientific Literature | |
| 5. | ALA4325128 | B | Agonist activity at STING in human PBMC cells assessed as increase in CXCL10 production at 1 to 10 uM measured after 4 hrs by ELISA | Homo sapiens | 3 | ALA4321869 | cell-based format | Scientific Literature | |
| 6. | ALA4325129 | B | Agonist activity at STING in human PBMC cells assessed as increase in CXCL10 production at 1.39 uM measured after 4 hrs by ELISA | Homo sapiens | 3 | ALA4321869 | cell-based format | Scientific Literature | |
| 7. | ALA4325130 | B | Agonist activity at STING in human PBMC cells assessed as increase in IL6 production at 0.1 to 10 uM measured after 4 hrs by ELISA | Homo sapiens | 3 | ALA4321869 | cell-based format | Scientific Literature | |
| 8. | ALA4325131 | B | Agonist activity at STING in human PBMC cells assessed as increase in IL6 production at 139 uM measured after 4 hrs by ELISA | Homo sapiens | 1 | ALA4321869 | cell-based format | Scientific Literature | |
| 9. | ALA4325132 | B | Agonist activity at STING in human PBMC cells assessed as increase in IFNbeta mRNA level at 69.6 uM measured after 4 hrs by qRT-PCR analysis | Homo sapiens | 1 | ALA4321869 | cell-based format | Scientific Literature | |
| 10. | ALA4325133 | B | Agonist activity at STING in human PBMC cells assessed as increase in CXCL10 mRNA level at 69.6 uM measured after 4 hrs by qRT-PCR analysis | Homo sapiens | 1 | ALA4321869 | cell-based format | Scientific Literature | |
| 11. | ALA4325134 | B | Agonist activity at STING in human PBMC cells assessed as increase in IL6 mRNA level at 69.6 uM measured after 4 hrs by qRT-PCR analysis | Homo sapiens | 1 | ALA4321869 | cell-based format | Scientific Literature | |
| 12. | ALA4325135 | B | Agonist activity at STING in human PBMC cells assessed as increase in IFNbeta mRNA level at 10 uM measured after 4 hrs by qRT-PCR analysis | Homo sapiens | 3 | ALA4321869 | cell-based format | Scientific Literature | |
| 13. | ALA4325136 | B | Agonist activity at STING in human PBMC cells assessed as increase in CXCL10 mRNA level at 10 uM measured after 4 hrs by qRT-PCR analysis | Homo sapiens | 3 | ALA4321869 | cell-based format | Scientific Literature | |
| 14. | ALA4325137 | B | Agonist activity at STING in human PBMC cells assessed as increase in IL6 mRNA level at 10 uM measured after 4 hrs by qRT-PCR analysis | Homo sapiens | 3 | ALA4321869 | cell-based format | Scientific Literature | |
| 15. | ALA4325138 | B | Agonist activity at STING in human PBMC cells assessed as increase in STING phosphorylation at Ser366 residue at 10 uM measured after 4 hrs by qRT-PCR analysis | Homo sapiens | 1 | ALA4321869 | cell-based format | Scientific Literature | |
| 16. | ALA4325139 | B | Agonist activity at STING in human PBMC cells assessed as increase in TBK1 phosphorylation at S172 residue at 10 uM measured after 4 hrs by qRT-PCR analysis | Homo sapiens | 1 | ALA4321869 | cell-based format | Scientific Literature | |
| 17. | ALA4325140 | B | Agonist activity at STING in human PBMC cells assessed as increase in IRF3 phosphorylation at S386 residue at 10 uM measured after 4 hrs by qRT-PCR analysis | Homo sapiens | 1 | ALA4321869 | cell-based format | Scientific Literature | |
| 18. | ALA4325141 | B | Agonist activity at STING in human wild-type THP1 cells assessed as increase in IFNbeta release at 0.1 to 10 uM measured after 24 hrs by ELISA | Homo sapiens | 3 | ALA4321869 | cell-based format | Scientific Literature | |
| 19. | ALA4325142 | B | Agonist activity at STING in human wild-type THP1 cells assessed as increase in CXCL10 production at 0.1 to 10 uM measured after 24 hrs by ELISA | Homo sapiens | 3 | ALA4321869 | cell-based format | Scientific Literature | |
| 20. | ALA4325143 | B | Agonist activity at STING in human wild-type THP1 cells assessed as increase in IL6 production at 0.1 to 10 uM measured after 24 hrs by ELISA | Homo sapiens | 3 | ALA4321869 | cell-based format | Scientific Literature |
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