| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4334313 | B | Inhibition of recombinant human N-terminal FLAG-tagged TET1 (1418 to 2136 residues) expressed in baculovirus infected sf9 cells assessed as reduction in oxidation of methylated dsDNA at 100 uM after 2 hrs by chemiluminescence assay relative to control | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
| 2. | ALA4334315 | B | Inhibition of recombinant human N-terminal FLAG-tagged TET1 (1418 to 2136 residues) expressed in baculovirus infected sf9 cells assessed as reduction in oxidation of methylated dsDNA after 2 hrs by chemiluminescence assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 3. | ALA4822190 | B | Inhibition of TET1 (unknown origin) | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 4. | ALA4822195 | B | Inhibition of TET1 (unknown origin) at 10 mM in presence of alpha-KG relative to control | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 5. | ALA4822196 | B | Inhibition of TET1 (unknown origin) at 50 mM in presence of alpha-KG relative to control | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 6. | ALA4822202 | B | Inhibition of recombinant human N-terminal Flag-tagged TET1 (1418 to 2136 residues) expressed in Baculovirus infected Sf9 cells assessed as reduction in 5hmc level incubated for 2 hrs by ELISA | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 7. | ALA5126409 | B | Inhibition of GST-tagged human TET1 (583 to 633 residues) expressed in Escherichia coli BL21 cells incubated for 30 mins by fluorescence polarization assay | Homo sapiens | 9 | cell-based format | Scientific Literature | ||
| 8. | ALA5135966 | B | Inhibition of recombinant human TET1 catalytic domain assessed as reduction of 5hmC formation at 125 uM using hemi-methylated synthetic oligomer 5'-AATTAGAA[5meC]GCTCCTT-3' as substrate measured over 5 to 60 mins by HPLC-ESI-MS/MS method relative to control | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 9. | ALA5135967 | B | Inhibition of recombinant human TET1 catalytic domain assessed as reduction of 5hmC formation at 125 uM using hemi-methylated synthetic oligomer 5'-AATTAGAA[5meC]GCTCCTT-3' as substrate incubated for 30 mins by LC-MS method | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 10. | ALA5135969 | B | Inhibition of recombinant human TET1 catalytic domain assessed as reduction of 5hmC formation at 125 uM using hemi-methylated synthetic oligomer 5'-AATTAGAA[5meC]GCTCCTT-3' as substrate incubated for 30 mins in presence of CuSO4 by LC-MS method | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 11. | ALA5135971 | B | Inhibition of recombinant human TET1 catalytic domain assessed as reduction of 5hmC formation up to 125 uM incubated for 30 mins by HPLC-ESI-MS/MS method | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 12. | ALA5135972 | B | Inhibition of recombinant human TET1 catalytic domain assessed as reduction of 5hmC formation at 25 uM incubated for 30 mins by HPLC-ESI-MS/MS method | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 13. | ALA5135973 | B | Inhibition of recombinant human TET1 assessed as reduction of 5hmC formation at 0.01 to 125 uM incubated for 30 mins in presence of 1 uM CuSO4 by HPLC-ESI-MS/MS method | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 14. | ALA5135974 | B | Inhibition of recombinant human TET1 assessed as reduction of 5hmC formation at 0.01 to 125 uM incubated for 30 mins in presence of 4 uM CuSO4 by HPLC-ESI-MS/MS method | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 15. | ALA5135977 | B | Inhibition of recombinant human TET1 catalytic domain assessed as reduction of 5fC formation at 125 uM using hemi-methylated synthetic oligomer 5'-AATTAGAA[5meC]GCTCCTT-3' as substrate measured over 5 to 60 mins by HPLC-ESI-MS/MS method relative to control | Homo sapiens | 1 | single protein format | Scientific Literature |
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