# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4420050 | Functional | Antagonist activity at recombinant human MrgprX4 expressed in HEK293 cells assessed as blockade of bilirubin-induced inositol phosphate accumulation incubated for 1 hr at at 37 degC followed by incubation for 30 mins at room temperature before bilirubin addition by HTRF assay relative to control | Homo sapiens | 4 | ALA4419180 | cell-based format | Patent Bioactivity Data | |
2. | ALA4420051 | Functional | Inverse agonist activity at recombinant human MrgprX4 expressed in HEK293 cells assessed as reduction in inositol phosphate accumulation incubated for 1 hr at at 37 degC followed by incubation for 30 mins at room temperature by HTRF assay relative to baseline | Homo sapiens | 4 | ALA4419180 | cell-based format | Patent Bioactivity Data | |
3. | ALA4808118 | Functional | Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay | Homo sapiens | 309 | ALA4806969 | cell-based format | Patent Bioactivity Data | |
4. | ALA4808119 | Functional | Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay | Homo sapiens | 17 | ALA4806969 | cell-based format | Patent Bioactivity Data | |
5. | ALA4808120 | Functional | Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay | Homo sapiens | 17 | ALA4806969 | cell-based format | Patent Bioactivity Data | |
6. | ALA4808121 | Functional | Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay | Homo sapiens | 17 | ALA4806969 | cell-based format | Patent Bioactivity Data | |
7. | ALA4808122 | Functional | Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay | Homo sapiens | 17 | ALA4806969 | cell-based format | Patent Bioactivity Data | |
8. | ALA4808123 | Functional | Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay | Homo sapiens | 17 | ALA4806969 | cell-based format | Patent Bioactivity Data | |
9. | ALA4808127 | Functional | Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assay | Homo sapiens | 8 | ALA4806969 | cell-based format | Patent Bioactivity Data | |
10. | ALA4808132 | Functional | Agonist activity at human MRGPRX4 expressed in HEK cells using preincubated compound in dark freezer condition for 24 hrs by HTRF assay | Homo sapiens | 1 | ALA4806969 | cell-based format | Patent Bioactivity Data | |
11. | ALA4808133 | Functional | Agonist activity at human MRGPRX4 expressed in HEK cells using preincubated compound in dark at room temperature for 24 hrs by HTRF assay | Homo sapiens | 1 | ALA4806969 | cell-based format | Patent Bioactivity Data | |
12. | ALA4808134 | Functional | Agonist activity at human MRGPRX4 expressed in HEK cells using preincubated compound in light at room temperature for 24 hrs by HTRF assay | Homo sapiens | 1 | ALA4806969 | cell-based format | Patent Bioactivity Data | |
13. | ALA4808135 | Functional | Agonist activity at human MRGPRX4 expressed in HEK cells using preincubated compound in blue light at room temperature for 24 hrs by HTRF assay | Homo sapiens | 1 | ALA4806969 | cell-based format | Patent Bioactivity Data | |
14. | ALA4883538 | Binding | PRESTO-Tango GPCRome screening (MRGPRX4) | 1 | ALA4507309 | single protein format | Donated Chemical Probes - SGC Frankfurt |