# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4482492 | Binding | Displacement of [125I]-C5a from C5a2 receptor (unknown origin) expressed in Flp-In CHO cell membranes at 100 uM incubated for 1 hr by microbeta scintillation counting assay | Homo sapiens | 2 | ALA4482309 | cell-based format | Patent Bioactivity Data | |
2. | ALA4482493 | Binding | Displacement of [125I]-C5a from C5a2 receptor (unknown origin) expressed in Flp-In CHO cell membranes incubated for 1 hr by microbeta scintillation counting assay | Homo sapiens | 2 | ALA4482309 | cell-based format | Patent Bioactivity Data | |
3. | ALA4482496 | Binding | Partial agonist activity at C5a2 receptor (unknown origin) expressed in HEK293 cells assessed as induction of beta-arrestin-2 recruitment incubated for 1 hr by BRET assay | Homo sapiens | 2 | ALA4482309 | cell-based format | Patent Bioactivity Data | |
4. | ALA4482497 | Binding | Partial agonist activity at C5a2 receptor (unknown origin) expressed in HEK293 cells assessed as induction of beta-arrestin-2 recruitment incubated for 1 hr by BRET assay relative to C5a | Homo sapiens | 2 | ALA4482309 | cell-based format | Patent Bioactivity Data | |
5. | ALA4482499 | Binding | Partial agonist activity at human C5a2 receptor assessed as induction of beta-arrestin-2 recruitment by DiscoverX Path Hunter kit based assay | Homo sapiens | 2 | ALA4482309 | single protein format | Patent Bioactivity Data | |
6. | ALA4482502 | Binding | Agonist activity at C5a2 receptor in HMDM assessed as inhibition of LPS-induced IL-6 release at 10 to 100 uM by ELISA | Homo sapiens | 1 | ALA4482309 | single protein format | Patent Bioactivity Data | |
7. | ALA4482503 | Binding | Agonist activity at C5a2 receptor in HMDM assessed as inhibition of LPS-induced TNFalpha release at 0.1 to 100 uM by ELISA | Homo sapiens | 2 | ALA4482309 | single protein format | Patent Bioactivity Data | |
8. | ALA4482504 | Binding | Agonist activity at C5a2 receptor in LPS-induced IHMDM assessed as effect on L10 release at 0.1 to 100 uM by ELISA | Homo sapiens | 2 | ALA4482309 | single protein format | Patent Bioactivity Data | |
9. | ALA4482505 | Binding | Agonist activity at C5a2 receptor in HMDM assessed as inhibition of LPS-induced IL-6 release at 100 uM by ELISA | Homo sapiens | 1 | ALA4482309 | single protein format | Patent Bioactivity Data | |
10. | ALA4482506 | Binding | Agonist activity at C5a2 receptor in HMDM assessed as inhibition of LPS-induced TNFalpha release at 100 uM in presence of C5a1 antagonist PMX53 by ELISA | Homo sapiens | 2 | ALA4482309 | single protein format | Patent Bioactivity Data | |
11. | ALA4883467 | Binding | PRESTO-Tango GPCRome screening (GPR77) | 1 | ALA4507309 | single protein format | Donated Chemical Probes - SGC Frankfurt |