| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4370053 | B | Inhibition of human IP6K2 using insP6 as substrate preincubated for 15 mins followed by substrate and measured after 30 mins by TR-FRET assay | Homo sapiens | 17 | single protein format | Scientific Literature | ||
| 2. | ALA4370056 | B | Inhibition of IP6K2 in human [3H]-inositol-labelled HCT116 cells assessed as reduction in insp7 levels after 3.5 hrs by HPLC analysis | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 3. | ALA4370057 | B | Inhibition of IP6K2 in human [3H]-inositol-labelled HCT116 cells assessed as reduction in insp7 levels at 10 uM after 3.5 hrs by HPLC analysis relative to control | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 4. | ALA4370060 | B | Inhibition of IP6K2 in human [3H]-inositol-labelled HCT116 cells assessed as reduction in insp7 levels at 2.5 uM up to 3.5 hrs by HPLC analysis relative to control | Homo sapiens | 3 | assay format | Scientific Literature | ||
| 5. | ALA4370061 | B | Inhibition of IP6K2 in human [3H]-inositol-labelled HCT116 cells assessed as reduction in insp7 levels at 2.5 uM after 30 mins by HPLC analysis | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 6. | ALA4370062 | B | Inhibition of IP6K2 in [3H]-inositol-labelled HEK293 cells assessed as reduction in insp7 levels at 2.5 uM after 3.5 hrs by HPLC analysis relative to control | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 7. | ALA4370066 | B | Inhibition of IP6K2 in human HCT116 cells assessed as AKT phosphorylation at T308 at 10 uM after 3 hrs by Western blot analysis | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 8. | ALA4370071 | B | Inhibition of IP6K2 in human [3H]-inositol-labelled HCT116 cells assessed as reduction in insp7 levels at 2.5 uM after 3.5 hrs by HPLC analysis relative to control | Homo sapiens | 7 | assay format | Scientific Literature | ||
| 9. | ALA4400031 | B | Inhibition of IP6K2 (unknown origin) in presence of ATP at Km concentration by Cheng-Prusoff equation analysis | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 10. | ALA4400034 | B | Inhibition of IP6K2 (unknown origin) incubated for 30 mins using IP6 as substrate in presence of ATP by ADP-Glo reagent based luminescence assay | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 11. | ALA5166045 | B | Inhibition of N-terminal 6His-tagged/TEV cleavage site fused recombinant human IP6K2 expressed in Escherichia coli assessed as inorganic phosphate release using InsP6 as substrate in presence of ATP measured after 60 to 120 mins by malachite green based colorimetric - DIPP1 coupled enzyme assay | Homo sapiens | 37 | assay format | Scientific Literature | ||
| 12. | ALA5166048 | B | Inhibition of recombinant full length human IP6K2 assessed as inorganic phosphate release measured after 30 mins by ADP-Glo Max assay | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 13. | ALA5166052 | B | Inhibition of N-terminal 6His-tagged/TEV cleavage site fused recombinant human IP6K2 expressed in Escherichia coli assessed as inhibition of [3H]-InsP6 phosphorylation at 10 nM measured after 180 mins by HPLC analysis | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 14. | ALA5166054 | B | Inhibition of N-terminal 6His-tagged/TEV cleavage site fused recombinant human IP6K2 expressed in Escherichia coli assessed as inhibition of [3H]-InsP6 phosphorylation measured after 180 mins by HPLC analysis | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 15. | ALA5166056 | B | Binding affinity to MBP-tagged recombinant human IP6K2 at 400 uM by isothermal titration calorimetry | Homo sapiens | 1 | single protein format | Scientific Literature |
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