#	Aladdin ID	Assay Type	Description	Organism	Compounds	Reference	BAO Format	Source
1.	ALA4417815	B	Inhibition of full-length recombinant human CYP46A1 assessed as cholesterol hydroxylation at 43 uM using cholesterol as substrate in presence of NADPH cytochrome P450 oxidoreductase by gas chromatography-mass spectrometry (Rvb = 100%)	Homo sapiens	40		single protein format	Patent Bioactivity Data
2.	ALA4417816	B	Binding affinity to full-length recombinant human CYP46A1 by spectral binding study	Homo sapiens	10		single protein format	Patent Bioactivity Data
3.	ALA4417817	B	Inhibition of full-length recombinant human CYP46A1 assessed as cholesterol hydroxylation using cholesterol as substrate in presence of NADPH cytochrome P450 oxidoreductase by gas chromatography-mass spectrometry	Homo sapiens	1		single protein format	Patent Bioactivity Data
4.	ALA4417819	B	Stimulation of full-length recombinant human CYP46A1 assessed as cholesterol hydroxylation at 43 uM using cholesterol as substrate in presence of NADPH cytochrome P450 oxidoreductase by gas chromatography-mass spectrometry (Rvb = 100%)	Homo sapiens	12		single protein format	Patent Bioactivity Data
5.	ALA4417820	B	Binding affinity to active site of full-length recombinant human CYP46A1 assessed as induction of type-II spectral response with minimum at 413 nm and maximum at 434 nm by spectral binding study	Homo sapiens	1		single protein format	Patent Bioactivity Data
6.	ALA4417825	B	Inhibition of full-length recombinant human CYP46A1 assessed as reduction in cholesterol 24-hydroxylation using cholesterol as substrate in presence of NADPH cytochrome P450 oxidoreductase by gas chromatography-mass spectrometry	Homo sapiens	1		single protein format	Patent Bioactivity Data
7.	ALA4417826	B	Inhibition of full-length recombinant human CYP46A1 assessed as reduction in 25- and 27-hydroxylation of 24S-hydroxy cholesterol in presence of NADPH cytochrome P450 oxidoreductase by gas chromatography-mass spectrometry	Homo sapiens	1		single protein format	Patent Bioactivity Data
8.	ALA4477128	B	Inhibition of human CH24H expressed in Freestyle-293 cells assessed as reduction in 24HC production at 1 uM incubated for 5 hrs using [14C]cholesterol as substrate relative to control	Homo sapiens	102		cell-based format	Patent Bioactivity Data
9.	ALA4613991	B	Activation of recombinant human C-terminal 4His-tagged CYP46A1 delta(2 to 50) mutant expressed in Escherichia coli using cholesterol as substrate measured after 30 mins in presence of cytochrome P450 oxidoreductase by gas chromatography-mass spectrometry	Homo sapiens	8		assay format	Scientific Literature
10.	ALA4613992	B	Activation of recombinant human C-terminal 4His-tagged CYP46A1 delta(2 to 50) mutant expressed in Escherichia coli at 20 uM using cholesterol as substrate measured after 30 mins in presence of cytochrome P450 oxidoreductase by gas chromatography-mass spectrometry relative to control	Homo sapiens	9		assay format	Scientific Literature
11.	ALA4613993	A	Inhibition of recombinant human C-terminal 4His-tagged CYP46A1 delta(2 to 50) mutant expressed in Escherichia coli at 60 to 100 uM using cholesterol as substrate measured after 30 mins in presence of cytochrome P450 oxidoreductase by gas chromatography-mass spectrometry	Homo sapiens	7		assay format	Scientific Literature
12.	ALA4613994	A	Inhibition of recombinant human C-terminal 4His-tagged CYP46A1 delta(2 to 50) mutant expressed in Escherichia coli at up to 100 uM using cholesterol as substrate measured after 30 mins in presence of cytochrome P450 oxidoreductase by gas chromatography-mass spectrometry	Homo sapiens	2		assay format	Scientific Literature
13.	ALA4613995	B	Binding affinity to recombinant human C-terminal 4His-tagged CYP46A1 delta(2 to 50) mutant expressed in Escherichia coli in absence of substrate by UV-spectrophotometric method	Homo sapiens	10		assay format	Scientific Literature
14.	ALA4613996	B	Binding affinity to recombinant human C-terminal 4His-tagged CYP46A1 delta(2 to 50) mutant expressed in Escherichia coli in presence of substrate by UV-spectrophotometric method	Homo sapiens	7		assay format	Scientific Literature
15.	ALA4613997	B	Activation of recombinant human C-terminal 4His-tagged CYP46A1 delta(2 to 50) mutant expressed in Escherichia coli at 20 uM using cholesterol as substrate measured after 30 mins in presence of cytochrome P450 oxidoreductase and L-Glu by gas chromatography-mass spectrometry relative to control	Homo sapiens	9		assay format	Scientific Literature
16.	ALA4614006	B	Binding affinity to recombinant human C-terminal 4His-tagged CYP46A1 delta(2 to 50) mutant expressed in Escherichia coli at 15 to 30 uM in absence of substrate by UV-spectrophotometric method	Homo sapiens	2		assay format	Scientific Literature
17.	ALA4614007	B	Binding affinity to recombinant human C-terminal 4His-tagged CYP46A1 delta(2 to 50) mutant expressed in Escherichia coli at 50 uM in presence of substrate by UV-spectrophotometric method	Homo sapiens	1		assay format	Scientific Literature
18.	ALA4614008	B	Binding affinity to recombinant human C-terminal 4His-tagged CYP46A1 delta(2 to 50) mutant expressed in Escherichia coli at 2 uM in presence of substrate by UV-spectrophotometric method	Homo sapiens	1		assay format	Scientific Literature
19.	ALA4614009	B	Binding affinity to recombinant human C-terminal 4His-tagged CYP46A1 delta(2 to 50) mutant expressed in Escherichia coli in absence of substrate at 24 degC by stopped-flow spectrophotometric method	Homo sapiens	2		assay format	Scientific Literature
20.	ALA4614010	B	Binding affinity to substrate bound recombinant human C-terminal 4His-tagged CYP46A1 delta(2 to 50) mutant expressed in Escherichia coli assessed as Kon rate of cholesterol by stopped-flow spectrophotometric method	Homo sapiens	2		assay format	Scientific Literature