Antiproliferative activity against pomalidomide resistant human AMO1 cells assessed as inhibition of cell proliferation at 1 uM incubated for 5 days by WST-1 assay
Antiproliferative activity against Mcl1-sensitive human AMO1 cells assessed as cell growth inhibition measured after 72 hrs by Celltiter-glo luminescence assay
Antitumour activity against Mcl1-sensitive human AMO1 cells xenografted in SCID mouse assessed as tumor growth inhibition at 100 mg/kg, ip administered daily for 14 days measured daily during compound dosing relative to control
Antitumour activity against Mcl1-sensitive human AMO1 cells xenografted in ip dosed SCID mouse assessed as tumor growth inhibition administered daily for 14 days measured daily during compound dosing
Antitumor activity against human AMO1 xenografted in CB-17 SCID mouse assessed as tumor growth inhibition at 12.5 mg/kg, iv administered weekly for upto week 4 measured post last dose measured on day 10
Antitumor activity against human AMO1 xenografted in CB-17 SCID mouse assessed as tumor growth inhibition at 12.5 mg/kg, iv administered daily measured on day 10
Antitumor activity against human AMO1 xenografted in CB-17 SCID mouse assessed as tumor regression at 12.5 mg/kg, iv administered for 5 consecutive days and observed upto day 35 post last dose
Antitumor activity against human AMO1 xenografted in CB-17 SCID mouse assessed as tumor growth inhibition administered intravenously for 5 consecutive days measured post-last dose
Antitumor activity against human AMO1 xenografted in CB-17 SCID mouse assessed as maximum tumor growth inhibition at 12.5 mg/kg, iv administered for 5 consecutive days measured post-last dose
Antitumor activity against human AMO1 xenografted in CB-17 SCID mouse assessed as maximum tumor growth inhibition at 3.125 mg/kg, iv administered for 5 consecutive days measured post-last dose
Antitumor activity against human AMO1 xenografted in CB-17 SCID mouse assessed as maximum tumor growth inhibition at 6.25 mg/kg, iv administered for 5 consecutive days measured post-last dose
Antitumor activity against human AMO1 cells xenografted in CB-17 SCID mouse assessed as time to reach tumor volume of 500 mm3 at 6.25 mg/kg, iv administered as bolus dose for 5 consecutive days
Antitumor activity against human AMO1 cells xenografted in CB-17 SCID mouse assessed as time to reach tumor volume of 500 mm3 at 12.5 mg/kg, iv administered as bolus dose for 5 consecutive days
Antitumor activity against human AMO1 cells xenografted in CB-17 SCID mouse assessed as time to reach tumor volume of 500 mm3 at 25 mg/kg, iv administered as bolus dose for 5 consecutive days
Antitumor activity against human AMO1 cells xenografted in CB-17 SCID mouse assessed as time to reach tumor volume of 500 mm3 at 50 mg/kg, iv administered as bolus dose for 5 consecutive days
Antitumor activity against human AMO1 xenografted in CB-17 SCID mouse assessed as tumor growth suppression at 50 mg/kg, iv administered for 5 consecutive days measured after 5 weeks
Antitumor activity against human AMO1 xenografted in CB-17 SCID mouse assessed as tumor growth suppression at 25 mg/kg, iv administered for 5 consecutive days and measured post-last dose
Antitumor activity against human AMO1 cells xenografted in CB-17 SCID mouse assessed as maximum tumor growth inhibition at 6.25 mg/kg, iv administered as bolus dose for 5 consecutive days measured on day 4 relative to control