| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA2383932 | F | Growth inhibition of human SET2 harboring JAK2 V617F mutant after 24 hrs by Alamar Blue assay | Homo sapiens | 3 | ALA2380256 | assay format | Scientific Literature | |
| 2. | ALA3374519 | F | Effect on total STAT5 level in human SET2 cells at 0.08 to 10 uM after 2 hrs by SDS-PAGE analysis | Homo sapiens | 1 | ALA3352511 | cell-based format | Scientific Literature | |
| 3. | ALA3375103 | F | Effect on total STAT3 level in human SET2 cells at 0.08 to 10 uM after 2 hrs by SDS-PAGE analysis | Homo sapiens | 1 | ALA3352511 | cell-based format | Scientific Literature | |
| 4. | ALA3375109 | F | Inhibition of STAT5 phosphorylation in human SET2 cells xenografted in SCID mouse assessed as tumor growth inhibition at 50 mg/kg, po as single dose measured up to 12 hrs post treatment | Homo sapiens | 1 | ALA3352511 | organism-based format | Scientific Literature | |
| 5. | ALA3375110 | F | Inhibition of STAT3 phosphorylation in human SET2 cells xenografted in SCID mouse assessed as tumor growth inhibition at 50 mg/kg, po as single dose measured up to 12 hrs post treatment | Homo sapiens | 1 | ALA3352511 | organism-based format | Scientific Literature | |
| 6. | ALA3375111 | F | Inhibition of STAT5 phosphorylation in human SET2 cells xenografted in SCID mouse assessed as tumor growth inhibition at 30 mg/kg, po as single dose measured at 1 to 3 hrs post treatment | Homo sapiens | 1 | ALA3352511 | organism-based format | Scientific Literature | |
| 7. | ALA3375112 | F | Inhibition of STAT3 phosphorylation in human SET2 cells xenografted in SCID mouse assessed as tumor growth inhibition at 30 mg/kg, po as single dose measured at 1 to 3 hrs post treatment | Homo sapiens | 1 | ALA3352511 | organism-based format | Scientific Literature | |
| 8. | ALA4029488 | F | Antitumor activity against human SET2 cells implanted in AML patients assessed as reduction in tumor volume administered intraperitoneally relative to control | Homo sapiens | 1 | ALA4028808 | cell-based format | Scientific Literature | |
| 9. | ALA4220218 | F | Antitumor activity against human SET2 cells xenografted in SCID Beige mouse assessed as tumor growth inhibition at 0.16 mg/kg, ip qd measured on day 33 relative to control | Homo sapiens | 1 | ALA4219051 | organism-based format | Scientific Literature | |
| 10. | ALA4220225 | F | Growth inhibition of human SET2 cells after 10 days by CellTiter-Glo assay | Homo sapiens | 1 | ALA4219051 | assay format | Scientific Literature | |
| 11. | ALA4323957 | F | Antiproliferative activity against human SET2 cells overexpressing JAK2 V716F mutant assessed as reduction in cell growth after 72 hrs by MTT assay | Homo sapiens | 2 | ALA4321837 | cell-based format | Scientific Literature | |
| 12. | ALA4324020 | F | Antitumor activity against human SET2 cells overexpressing JAK2 V617F mutant xenografted in NOD/SCID mouse assessed as tumor growth inhibition at 30 mg/kg, po qd for 18 days measured every 2 days for 18 days by caliper method relative to control | Homo sapiens | 1 | ALA4321837 | organism-based format | Scientific Literature | |
| 13. | ALA4324021 | F | Antitumor activity against human SET2 cells overexpressing JAK2 V617F mutant xenografted in NOD/SCID mouse assessed as tumor growth inhibition at 60 mg/kg, po qd for 18 days measured every 2 days for 18 days by caliper method relative to control | Homo sapiens | 1 | ALA4321837 | organism-based format | Scientific Literature | |
| 14. | ALA4369006 | F | Induction of apoptosis in human SET2 cells after 48 hrs by Annexin-V/propidium iodide staining based assay | Homo sapiens | 1 | ALA4368853 | cell-based format | Scientific Literature | |
| 15. | ALA4630184 | F | Growth inhibition on human SET2 cells measured upto 12 days by Cell Titer-Glo luminescent cell viability assay | Homo sapiens | 1 | ALA4627402 | cell-based format | Scientific Literature | |
| 16. | ALA4723816 | F | Induction of cell cycle arrest in human SET2 cells assessed as accumulation at G0/G1 phase incubated for 24 hrs by propidium iodide staining based flow cytometry | Homo sapiens | 1 | ALA4715869 | cell-based format | Scientific Literature | |
| 17. | ALA4723844 | F | Antitumor activity against human SET2 cells xenografted in NOD/SCID mouse assessed as tumor growth inhibition at 15 mg/kg, po qd administered for 16 days and measured every 2 days relative to control | Homo sapiens | 1 | ALA4715869 | organism-based format | Scientific Literature | |
| 18. | ALA4723845 | F | Antitumor activity against human SET2 cells xenografted in NOD/SCID mouse assessed as tumor growth inhibition at 30 mg/kg, po qd administered for 16 days and measured every 2 days relative to control | Homo sapiens | 1 | ALA4715869 | organism-based format | Scientific Literature | |
| 19. | ALA4723846 | F | Antitumor activity against human SET2 cells xenografted in NOD/SCID mouse assessed as tumor growth inhibition at 60 mg/kg, po qd administered for 16 days and measured every 2 days relative to control | Homo sapiens | 2 | ALA4715869 | organism-based format | Scientific Literature | |
| 20. | ALA4723851 | F | Induction of apoptosis in human SET-2 cells assessed as necrotic cells at 0.05 uM incubated for 24 hrs by Annexin V/PI staining based flow cytometric analysis (Rvb = 0.78%) | Homo sapiens | 1 | ALA4715869 | cell-based format | Scientific Literature |
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