# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4323257 | B | Induction of GSPT1 degradation in human RS4:11 cells measured after 24 hrs by Western blot analysis | Homo sapiens | 6 | ALA4321819 | cell-based format | Scientific Literature | |
2. | ALA4323260 | B | Induction of GSPT1 degradation in human MDA-MB-231 cells transfected with CRBN siRNA LQ-021086-10-0002 assessed as decrease in GSPT1 protein level at 0.1 uM after 2 to 24 hrs by Western blot analysis | Homo sapiens | 1 | ALA4321819 | cell-based format | Scientific Literature | |
3. | ALA4323261 | B | Induction of GSPT1 degradation in human MDA-MB-231 cells transfected with CRBN siRNA LQ-021086-11-0002 assessed as decrease in GSPT1 protein level at 0.1 uM after 2 to 24 hrs by Western blot analysis | Homo sapiens | 1 | ALA4321819 | cell-based format | Scientific Literature | |
4. | ALA4323262 | B | Induction of GSPT1 degradation in human MDA-MB-468 cells transfected with CRBN siRNA LQ-021086-10-0002 assessed as decrease in GSPT1 protein level at 0.1 uM after 2 to 24 hrs by Western blot analysis | Homo sapiens | 1 | ALA4321819 | cell-based format | Scientific Literature | |
5. | ALA4323263 | B | Induction of GSPT1 degradation in human MDA-MB-468 cells transfected with CRBN siRNA LQ-021086-11-0002 assessed as decrease in GSPT1 protein level at 0.1 uM after 2 to 24 hrs by Western blot analysis | Homo sapiens | 1 | ALA4321819 | cell-based format | Scientific Literature | |
6. | ALA4323264 | B | Induction of GSPT1 degradation in human RS4:11 cells at 0.1 uM pretreated with Nedd8 inhibitor PR-171 followed by compound treatment after 2 hrs by Western blot analysis | Homo sapiens | 1 | ALA4321819 | cell-based format | Scientific Literature | |
7. | ALA4323266 | B | Induction of GSPT1 degradation in human RS4:11 cells at 0.1 uM pretreated with proteasome inhibitor MLN4924 followed by compound treatment after 2 hrs by Western blot analysis | Homo sapiens | 1 | ALA4321819 | cell-based format | Scientific Literature | |
8. | ALA5051114 | B | Induction of GSPT1 degradation in human GripTite 293 MSR cells assessed as reduction in GSPT1 level measured by PathHunter assay | Homo sapiens | 65 | ALA5050840 | cell-based format | Patent Bioactivity Data | |
9. | ALA5098345 | B | Induction of GSPT1 degradation in human KARPAS-299 cells assessed as reduction in GSPT1 protein expression at 0.01 to 1 uM measured after 24 hrs by Western blot analysis | Homo sapiens | 1 | ALA5096194 | cell-based format | Scientific Literature | |
10. | ALA5098346 | B | Induction of GSPT1 degradation in human KARPAS-299 cells assessed as reduction in GSPT1 protein expression at 1 uM measured after 24 hrs by Western blot analysis | Homo sapiens | 2 | ALA5096194 | cell-based format | Scientific Literature | |
11. | ALA5149825 | B | Induction of GSPT1 degradation in PXR knock in human SNU-C4 cells at 0.001 to 10 uM measured after 24 hrs by Western blot analysis | Homo sapiens | 1 | ALA5143746 | cell-based format | Scientific Literature | |
12. | ALA5149826 | B | Induction of GSPT1 degradation in PXR knock in human SNU-C4 cells at 10 uM measured after 24 hrs in presence of proteasome inhibitor MG-132 by Western blot analysis | Homo sapiens | 1 | ALA5143746 | cell-based format | Scientific Literature | |
13. | ALA5149827 | B | Induction of GSPT1 degradation in PXR knock in human SNU-C4 cells transfected with siCRBN at 0.1 to 10 uM measured after 24 hrs by Western blot analysis | Homo sapiens | 1 | ALA5143746 | cell-based format | Scientific Literature | |
14. | ALA5149831 | B | Induction of GSPT1 degradation in PXR knock in human SNU-C4 cells at 10 uM measured after 24 hrs by Western blot analysis relative to control | Homo sapiens | 13 | ALA5143746 | cell-based format | Scientific Literature | |
15. | ALA5226030 | B | Induction of HiBiT-tagged GSPT1 degradation in HEK293T cells upto 10 uM incubated for 4 hrs | Homo sapiens | 1 | ALA5223179 | cell-based format | Scientific Literature | |
16. | ALA5226031 | B | Induction of GSPT1 degradation in human KOPT-K1 cells upto 100 nM incubated for 4 hrs by immunoblotting analysis | Homo sapiens | 2 | ALA5223179 | cell-based format | Scientific Literature |