| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4332053 | B | Modulation of Cluc-FGF14 (unknown origin)/CD4-Nav1.6-Nluc (unknown origin) protein-protein interaction using FGF14/NAV1.6 using HEK293 cells expressing FGF14/Nav1.6 assessed as luminescent response at 50 uM by split luciferase complementation assay relative to control | Homo sapiens | 7 | cell-based format | Scientific Literature | ||
| 2. | ALA4332055 | B | Inhibition of Cluc-FGF14 (unknown origin)/CD4-Nav1.6-Nluc (unknown origin) protein-protein interaction using FGF14/NAV1.6 using HEK293 cells expressing FGF14/Nav1.6 by split luciferase complementation assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 3. | ALA4703716 | B | Modulation of human recombinant FGF14-Nav1.6 C-terminal domain expressed in Escherichia coli BL21 (DE3) protein-protein interaction assessed as dissociation constant by SPR analysis (Rvb = 228.5 +/- 57.54 nM) | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 4. | ALA4703717 | B | Modulation of human recombinant FGF14-Nav1.6 C-terminal domain expressed in Escherichia coli BL21 (DE3) protein-protein interaction assessed as association rate constant by SPR analysis (Rvb = 2.18X10^4 +/- 1.6X10^2 /M/s) | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 5. | ALA4703718 | B | Modulation of human recombinant FGF14-Nav1.6 C-terminal domain expressed in Escherichia coli BL21 (DE3) protein-protein interaction assessed as dissociation rate constant by SPR analysis (Rvb = 1.71 X 10^-3 +/- 1.02 X 10^-5 /M/s) | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 6. | ALA4703725 | B | Modulation of recombinant human Nav1.6 C-terminal tail (1763 to 1976 residues)-FGF14 (64 to 252 residues) protein-protein interaction expressed in HEK293 cells assessed as peak current density at 10 uM incubated for 30 mins by whole cell patch clamp electrophysiology assay (Rvb = -19.3 +/- 1.3) | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 7. | ALA4703726 | B | Modulation of recombinant human Nav1.6 C-terminal tail (1763 to 1976 residues)-FGF14 (64 to 252 residues) protein-protein interaction expressed in HEK293 cells assessed as change in time constant of inactivation at 10 uM incubated for 30 mins by cell patch clamp electrophysiology assay (Rvb = 1.58 +/- 0.18 ms) | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 8. | ALA4703727 | B | Modulation of recombinant human Nav1.6 C-terminal tail (1763 to 1976 residues)-FGF14 (64 to 252 residues) protein-protein interaction expressed in HEK293 cells assessed as half activation voltage at 10 uM incubated for 30 mins by cell patch clamp electrophysiology assay (Rvb = -21.4 +/- 1 mv) | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 9. | ALA4703728 | B | Modulation of recombinant human Nav1.6 C-terminal tail (1763 to 1976 residues)-FGF14 (64 to 252 residues) protein-protein interaction expressed in HEK293 cells assessed as steady state half inactivation voltage at 10 uM incubated for 30 mins by whole cell patch clamp electrophysiology assay (Rvb = -55.1 +/- 2 mV) | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 10. | ALA4703729 | B | Modulation of recombinant human Nav1.6 C-terminal tail (1763 to 1976 residues)-FGF14 (64 to 252 residues) protein-protein interaction expressed in HEK293 cells assessed as long-term inactivation at depolarization cycle 2 at 10 uM incubated for 30 mins by cell patch clamp electrophysiology assay (Rvb = 1 +/- 0.02 No_unit) | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 11. | ALA4703730 | B | Modulation of recombinant human Nav1.6 C-terminal tail (1763 to 1976 residues)-FGF14 (64 to 252 residues) protein-protein interaction expressed in HEK293 cells assessed as long-term inactivation at depolarization cycle 3 at 10 uM incubated for 30 mins by cell patch clamp electrophysiology assay (Rvb = 0.99 +/- 0.04 No_unit) | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 12. | ALA4703731 | B | Modulation of recombinant human Nav1.6 C-terminal tail (1763 to 1976 residues) -FGF14 (64 to 252 residues) protein-protein interaction expressed in HEK293 cells assessed as long-term inactivation at depolarization cycle 4 at 10 uM incubated for 30 mins by cell patch clamp electrophysiology assay (Rvb = 0.98 +/- 0.06 No_unit) | Homo sapiens | 1 | cell-based format | Scientific Literature |
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