| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4316365 | B | Inhibition of Nedd8-cullin1 (unknown origin) adduct formation assessed as decrease in cullin1 neddylation at 50 uM preincubated for 10 mins followed by ATP addition and measured after 30 mins by immunoblot analysis | Homo sapiens | 4 | protein format | Scientific Literature | ||
| 2. | ALA4316366 | B | Inhibition of Nedd8-cullin1 adduct formation in human A549 cells assessed as decrease in cullin1 neddylation at 100 uM incubated for 6 to 12 hrs by Western blot analysis | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 3. | ALA4316367 | B | Inhibition of Nedd8-cullin1 (unknown origin) assessed as decrease in cullin1-Nedd8 adduct formation at 25 to 50 uM preincubated for 10 mins followed by ATP addition and measured after 30 mins by immunoblot analysis | Homo sapiens | 1 | protein format | Scientific Literature | ||
| 4. | ALA4316369 | B | Competitive inhibition of Nedd8-cullin1 (unknown origin) adduct formation at 12.5 to 50 uM assessed as substrate Vmax by Lineweaver-Burk plot analysis | Homo sapiens | 1 | protein format | Scientific Literature | ||
| 5. | ALA4316370 | B | Competitive inhibition of Nedd8-cullin1 (unknown origin) adduct formation at 12.5 to 50 uM assessed as increase in substrate Km by Lineweaver-Burk plot analysis | Homo sapiens | 1 | protein format | Scientific Literature | ||
| 6. | ALA4316386 | B | Inhibition of Nedd8-cullin1 adduct formation in human A549 cells assessed as decrease in cullin1 neddylation at 60 to 80 uM measured after 6 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 7. | ALA4316387 | B | Inhibition of Nedd8-cullin1 adduct formation in human A549 cells assessed as decrease in cullin1 neddylation at 75 uM measured after 6 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 8. | ALA4316388 | B | Inhibition of Nedd8-cullin1 adduct formation in human A549 cells assessed as decrease in cullin1 neddylation at 50 uM measured after 6 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 9. | ALA4316394 | B | Inhibition of Nedd8-cullin1 (unknown origin) adduct formation assessed as decrease in cullin1 neddylation at 10 uM preincubated for 10 mins followed by ATP addition and measured after 30 mins by immunoblot analysis | Homo sapiens | 1 | protein format | Scientific Literature | ||
| 10. | ALA4316395 | B | Competitive inhibition of Nedd8-cullin1 (unknown origin) adduct formation assessed as decrease in cullin1-Nedd8 adduct formation at 50 uM preincubated for 10 mins followed by ATP addition and measured after 30 mins by immunoblot analysis | Homo sapiens | 1 | protein format | Scientific Literature |
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