# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4312979 | Binding | Induction of CRBN-mediated CDK4 degradation in human U251 cells after 24 hrs by immunoblot analysis | Homo sapiens | 17 | ALA4311951 | cell-based format | Scientific Literature | |
2. | ALA4312987 | Binding | Induction of CRBN-mediated CDK4 degradation in human U251 cells at 1 uM after 24 hrs by immunoblot analysis | Homo sapiens | 8 | ALA4311951 | cell-based format | Scientific Literature | |
3. | ALA4312999 | Binding | Induction of CRBN-mediated CDK4 degradation in human U251 cells assessed as CDK4 level at 0.1 nM after 24 hrs by immunoblot analysis relative to control | Homo sapiens | 1 | ALA4311951 | cell-based format | Scientific Literature | |
4. | ALA4313000 | Binding | Induction of CRBN-mediated CDK4 degradation in human U251 cells assessed as CDK4 level at 0.33 nM after 24 hrs by immunoblot analysis relative to control | Homo sapiens | 1 | ALA4311951 | cell-based format | Scientific Literature | |
5. | ALA4313001 | Binding | Induction of CRBN-mediated CDK4 degradation in human U251 cells assessed as CDK4 level at 1 nM after 24 hrs by immunoblot analysis relative to control | Homo sapiens | 1 | ALA4311951 | cell-based format | Scientific Literature | |
6. | ALA4313002 | Binding | Induction of CRBN-mediated CDK4 degradation in human U251 cells assessed as CDK4 level at 3.3 nM after 24 hrs by immunoblot analysis relative to control | Homo sapiens | 1 | ALA4311951 | cell-based format | Scientific Literature | |
7. | ALA4313003 | Binding | Induction of CRBN-mediated CDK4 degradation in human U251 cells assessed as CDK4 level at 10 nM after 24 hrs by immunoblot analysis relative to control | Homo sapiens | 1 | ALA4311951 | cell-based format | Scientific Literature | |
8. | ALA4313004 | Binding | Induction of CRBN-mediated CDK4 degradation in human U251 cells assessed as CDK4 level at 33 nM after 24 hrs by immunoblot analysis relative to control | Homo sapiens | 1 | ALA4311951 | cell-based format | Scientific Literature | |
9. | ALA4313005 | Binding | Induction of CRBN-mediated CDK4 degradation in human U251 cells assessed as CDK4 level at 100 nM after 24 hrs by immunoblot analysis relative to control | Homo sapiens | 1 | ALA4311951 | cell-based format | Scientific Literature | |
10. | ALA4313006 | Binding | Induction of CRBN-mediated CDK4 degradation in human U251 cells assessed as CDK4 level at 330 nM after 24 hrs by immunoblot analysis relative to control | Homo sapiens | 1 | ALA4311951 | cell-based format | Scientific Literature | |
11. | ALA4313007 | Binding | Induction of CRBN-mediated CDK4 degradation in human U251 cells assessed as CDK4 level at 1000 nM after 24 hrs by immunoblot analysis relative to control | Homo sapiens | 1 | ALA4311951 | cell-based format | Scientific Literature | |
12. | ALA4313008 | Binding | Induction of CRBN-mediated CDK4 degradation in human U251 cells assessed as CDK4 level at 3300 nM after 24 hrs by immunoblot analysis relative to control | Homo sapiens | 1 | ALA4311951 | cell-based format | Scientific Literature | |
13. | ALA4313009 | Binding | Induction of CRBN-mediated CDK4 degradation in human U251 cells assessed as CDK4 level at 10000 nM after 24 hrs by immunoblot analysis relative to control | Homo sapiens | 1 | ALA4311951 | cell-based format | Scientific Literature | |
14. | ALA4313020 | Binding | Induction of CRBN-mediated CDK4 degradation in human U251 cells at 500 nM after 4 hrs by immunoblot analysis | Homo sapiens | 1 | ALA4311951 | cell-based format | Scientific Literature | |
15. | ALA4313029 | Binding | Induction of CRBN-mediated CDK4 degradation in human U251 cells at 500 nM after 4 hrs by TMT Mass spectrometry based proteomic analysis | Homo sapiens | 1 | ALA4311951 | cell-based format | Scientific Literature | |
16. | ALA4313033 | Binding | Protac activity at CRBN/FLAG-tagged human CDK4 expressed in human U251 cells at 500 nM after 28 hrs by immunoblot analysis | Homo sapiens | 1 | ALA4311951 | cell-based format | Scientific Literature | |
17. | ALA4313055 | Binding | Induction of CRBN-mediated CDK4 in palbociclib-resistant human MCF-7 cells with CDK6 gene amplification at 1 uM after 24 hrs by immunoblot analysis | Homo sapiens | 1 | ALA4311951 | assay format | Scientific Literature | |
18. | ALA4313056 | Binding | Induction of CRBN-mediated CDK4 in palbociclib-resistant Fat1 knockout human MCF-7 cells with at 1 uM after 6 days by immunoblot analysis | Homo sapiens | 1 | ALA4311951 | assay format | Scientific Literature | |
19. | ALA4341453 | Binding | Induction of CRBN-mediated CDK4 degradation in human MIAPaCa2 cells at 0.5 uM measured after 4 hrs by western blot analysis | Homo sapiens | 4 | ALA4340529 | cell-based format | Scientific Literature | |
20. | ALA4341464 | Binding | Induction of CRBN-mediated CDK4 degradation in human MIAPaCa2 cells at 0.1 uM measured after 4 hrs by western blot analysis | Homo sapiens | 1 | ALA4340529 | cell-based format | Scientific Literature |