| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4313019 | A | Induction of CRBN-mediated CDK2 degradation in human U251 cells at 500 nM after 4 hrs by immunoblot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 2. | ALA4341454 | B | Induction of CRBN-mediated CDK2 degradation in human MIAPaCa2 cells at 0.5 uM measured after 24 hrs by western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 3. | ALA4604217 | B | Protac activity at CRBN/CDK2 in AR-negative human PC3 cells assessed as induction of CDK2 protein degradation at 1 uM after 12 hrs by Western blot analysis | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 4. | ALA4604221 | B | Protac activity at CRBN/CDK2 in AR-negative human PC3 cells assessed as induction of CDK2 protein degradation at 30 uM after 12 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 5. | ALA4604224 | B | Protac activity at CRBN/CDK2 in AR-negative human PC3 cells assessed as induction of CDK2 protein degradation at 50 nM after 12 hrs by Western blot analysis | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 6. | ALA4604236 | B | Protac activity at CRBN/CDK2 in AR-negative human PC3 cells assessed as CDK2 degradation at 1 uM preincubated with pomalidomide for 2 hrs and measured after 8 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 7. | ALA4604237 | B | Protac activity at CRBN/CDK2 in AR-negative human PC3 cells assessed as CDK2 degradation at 1 uM preincubated with FN-1501 for 2 hrs and measured after 8 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 8. | ALA4604238 | B | Protac activity at CRBN/CDK2 in AR-negative human PC3 cells assessed as CDK2 degradation at 1 uM preincubated with proteasome inhibitor MG132 for 2 hrs and measured after 8 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 9. | ALA4734725 | B | Protac activity at CRBN/CDK2 in human A-375 cells assessed as induction of CDK2 protein degradation after 12 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 10. | ALA4734731 | B | Protac activity at CRBN/CDK2 in human A-375 cells assessed as induction of CDK2 protein degradation at 1000 nM by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 11. | ALA4819961 | B | PROTAC activity at CRBN/CDK2 in human MV4-11 cells assessed as induction of CDK2 degradation at 31.25 to 500 nM measured after 3 hrs by western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 12. | ALA4822292 | B | Protac activity at CDK2/CRBN in human HEK293 cells assessed as degradation of CDK2 at 0.01 to 10 uM incubated for 24 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 13. | ALA4822301 | B | Protac activity at CDK2/CRBN in human HEK293 cells assessed as degradation of CDK2 at 1 uM measured upto 24 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 14. | ALA4831160 | B | Protac activity at CRBN/CDK2 in human MDA-MB-231 cells assessed as induction of degradation of CDK2 at 0.01 to 2.5 uM incubated for 4 to 8 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 15. | ALA4831173 | B | Protac activity at CRBN/CDK2 in human MDA-MB-231 cells assessed as induction of degradation of CDK2 at 100 to 500 nM incubated for 4 to 8 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 16. | ALA5046683 | B | Protac activity at CDK2/CRBN E3 ligase in human HEI-OC1 cells assessed as induction of CDK2 protein degradation measured after 24 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 17. | ALA5046684 | B | Protac activity at CDK2/CRBN E3 ligase in human HEI-OC1 cells assessed as induction of CDK2 protein degradation in presence of MG-132 proteasome inhibitor measured after 24 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 18. | ALA5046686 | B | Protac activity at CDK2/CRBN E3 ligase in human HEI-OC1 cells assessed as induction of CDK2 protein degradation at 100 nM measured after 24 hrs by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature |
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