| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4322318 | B | Induction of CRBN-mediated MDM2 degradation in human HeLa cells at 10 uM incubated for 12 hrs by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 2. | ALA4353451 | B | Protac activity at CRBN/MDM2 in human RS4:11 cells assessed as increase in degradation of MDM2 at 10 to 100 nM measured after 12 hrs by Western blot analysis | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 3. | ALA4353452 | B | Protac activity at CRBN/MDM2 in human RS4:11 cells assessed as increase in degradation of MDM2 at 100 nM by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 4. | ALA4353453 | B | Protac activity at CRBN/MDM2 in human RS4:11 cells assessed as increase in accumulation of p53 at 100 nM by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 5. | ALA4353454 | B | Protac activity at CRBN/MDM2 in human RS4:11 cells assessed as increase in degradation of MDM2 by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 6. | ALA4353455 | B | Protac activity at CRBN/MDM2 in human RS4:11 cells assessed as maximal MDM2 degradation level at 100 nM after 24 hrs by Western blot analysis relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 7. | ALA4353456 | B | Protac activity at CRBN/MDM2 in human RS4:11 cells assessed as MDM2 degradation by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 8. | ALA4353457 | B | Protac activity at CRBN/MDM2 in human RS4:11 cells assessed as reduction in MDM2 degradation at 100 nM preincubated with ((4S,5R)-2-(4-(tert-butyl)-2-ethoxyphenyl)-4,5-bis(4-chlorophenyl)-4,5-dihydro-1H-imidazol-1-yl)(piperazin-1-yl)methanone for 2 hrs followed by compound addition measured after 4 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 9. | ALA4353458 | B | Protac activity at CRBN/MDM2 in human RS4:11 cells assessed as reduction in MDM2 degradation at 100 nM preincubated with lenalidomide for 2 hrs followed by compound addition measured after 4 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 10. | ALA4353459 | B | Protac activity at CRBN/MDM2 in human RS4:11 cells assessed as MDM2 degradation at 100 nM preincubated with proteasome inhibitior MG132 for 2 hrs followed by compound addition measured after 4 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 11. | ALA4353460 | B | Protac activity at CRBN/MDM2 in human RS4:11 cells assessed as upregulation of MDM2 expression at 1 uM measured after 6 hrs by qRT-PCR method | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 12. | ALA4353461 | B | Protac activity at CRBN/MDM2 in human RS4:11 cells assessed as upregulation of P21 expression at 1 uM measured after 6 hrs by qRT-PCR method | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 13. | ALA4353462 | B | Protac activity at CRBN/MDM2 in human RS4:11 cells assessed as upregulation of MDM2 expression at 100 nM measured after 6 hrs by qRT-PCR method | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 14. | ALA4353463 | B | Protac activity at CRBN/MDM2 in human RS4:11 cells assessed as upregulation of P21 expression at 100 nM measured after 6 hrs by qRT-PCR method | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 15. | ALA4353464 | B | Protac activity at CRBN/MDM2 in human RS4:11 cells assessed as effect on TP53 expression at 1 uM measured after 6 hrs by qRT-PCR method | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 16. | ALA4353465 | B | Protac activity at CRBN/MDM2 in human RS4:11 cells assessed as effect on TP53 expression at 30 to 100 nM measured after 6 hrs by qRT-PCR method | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 17. | ALA4353466 | B | Protac activity at CRBN/MDM2 in human RS4:11 cells assessed as degradation of MDM2 at 100 nM to 1 uM by Westernblot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 18. | ALA4353467 | B | Protac activity at CRBN/MDM2 in human RS4:11 cells assessed as upregulation of P53 expression at 100 nM to 1 uM by Westernblot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 19. | ALA4353468 | B | Protac activity at CRBN/MDM2 in human RS4:11 cells assessed as increase in P21 expression at 100 nM to 1 uM by Westernblot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 20. | ALA4353485 | B | Protac activity at CRBN/MDM2 in human RS4:11 cells assessed as PARP cleavage after 6 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature |
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