# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4313024 | A | Induction of CRBN-mediated MEK1 degradation in human U251 cells at 500 nM after 4 hrs by immunoblot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
2. | ALA4324544 | B | Protac activity against CRBN/MEK1 in human HT-29 cells harboring BRAF V600E variant assessed as degradation of MEK1 at 0.3 to 3 uM after 24 hrs by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
3. | ALA4712219 | B | Protac activity at CRBN/MEK1 in human HT-29 cells assessed as induction of MEK1 degradation at 0.3 to 3 uM incubated for 24 hrs by Western blot analysis | Homo sapiens | 7 | cell-based format | Scientific Literature | ||
4. | ALA4712228 | B | Protac activity at CRBN/MEK1 in human HT-29 cells assessed as time for induction of MEK1 degradation at 0.3 uM by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
5. | ALA4712230 | B | Protac activity at CRBN/MEK1 in human HT-29 cells assessed as time for maximum induction of MEK1 degradation at 0.3 uM by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
6. | ALA4712232 | B | Protac activity at CRBN/MEK1 in human SK-MEL-28 cells assessed as induction of MEK1 degradation at 0.3 to 3 uM incubated for 24 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
7. | ALA4712239 | B | Protac activity at CRBN/MEK1 in human HT-29 cells assessed as induction of MEK1 degradation incubated for 24 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
8. | ALA4712241 | B | Protac activity at CRBN/MEK1 in human SK-MEL-28 cells assessed as induction of MEK1 degradation incubated for 24 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature |