# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4361881 | Binding | Protac activity at CRBN/IRAK4 in human PBMC assessed as induction of degradation of IRAK4 incubated for 24 hrs by Western blot analysis relative to control | Homo sapiens | 2 | ALA4359855 | protein format | Scientific Literature | |
2. | ALA4724654 | Binding | Protac activity at CRBN/IRAK4 in human TMD8 cells assessed as inhibition of NF-kappaB p65 phosphorylation by Western blot analysis | Homo sapiens | 1 | ALA4715903 | cell-based format | Scientific Literature | |
3. | ALA4724655 | Binding | Protac activity at CRBN/IRAK4 in human OCILY10 cells assessed as inhibition of NF-kappaB p65 phosphorylation by Western blot analysis | Homo sapiens | 1 | ALA4715903 | cell-based format | Scientific Literature | |
4. | ALA4724656 | Binding | Protac activity at CRBN/IRAK4 in human TMD8 cells assessed as inhibition of IKKalpha/beta phosphorylation by Western blot analysis | Homo sapiens | 1 | ALA4715903 | cell-based format | Scientific Literature | |
5. | ALA4724657 | Binding | Protac activity at CRBN/IRAK4 in human OCILY10 cells assessed as inhibition of IKKalpha/beta phosphorylation by Western blot analysis | Homo sapiens | 1 | ALA4715903 | cell-based format | Scientific Literature | |
6. | ALA4724658 | Binding | Protac activity at CRBN/IRAK4 in human TMD8 cells assessed as inhibition of IRAK4 phosphorylation by Western blot analysis | Homo sapiens | 1 | ALA4715903 | cell-based format | Scientific Literature | |
7. | ALA4724659 | Binding | Protac activity at CRBN/IRAK4 in human OCILY10 cells assessed as inhibition of IRAK4 phosphorylation by Western blot analysis | Homo sapiens | 1 | ALA4715903 | cell-based format | Scientific Literature | |
8. | ALA4724660 | Binding | Protac activity at CRBN/IRAK4 in human TMD8 cells harboring MYD88 L265P mutant assessed as induction of IRAK4 degradation at 1 uM in presence of IRAK4 inhibitor, Methyl 4-(5-ethoxy-1-methyl-6-(6-(trifluoromethyl)picolinamido)-1H-benzo[d]imidazol-2-yl)-2,2-dimethylbutanoate by Western blot analysis | Homo sapiens | 1 | ALA4715903 | cell-based format | Scientific Literature | |
9. | ALA4724661 | Binding | Protac activity at CRBN/IRAK4 in human OCILY10 cells harboring MYD88 L265P mutant assessed as induction of IRAK4 degradation at 1 uM in presence of IRAK4 inhibitor, Methyl 4-(5-ethoxy-1-methyl-6-(6-(trifluoromethyl)picolinamido)-1H-benzo[d]imidazol-2-yl)-2,2-dimethylbutanoate by Western blot analysis | Homo sapiens | 1 | ALA4715903 | cell-based format | Scientific Literature | |
10. | ALA4724662 | Binding | Protac activity at CRBN/IRAK4 in human TMD8 cells harboring MYD88 L265P mutant assessed as induction of IRAK4 degradation at 1 uM in presence of CRBN recruiter, pomalidomide by Western blot analysis | Homo sapiens | 1 | ALA4715903 | cell-based format | Scientific Literature | |
11. | ALA4724663 | Binding | Protac activity at CRBN/IRAK4 in human OCILY10 cells harboring MYD88 L265P mutant assessed as induction of IRAK4 degradation at 1 uM in presence of CRBN recruiter, pomalidomide by Western blot analysis | Homo sapiens | 1 | ALA4715903 | cell-based format | Scientific Literature | |
12. | ALA4724664 | Binding | Protac activity at CRBN/IRAK4 in human TMD8 cells harboring MYD88 L265P mutant assessed as induction of IRAK4 degradation at 1 uM pretreated with proteasome inhibitor, MG132 for 2 hrs followed by compound addition by Western blot analysis | Homo sapiens | 1 | ALA4715903 | cell-based format | Scientific Literature | |
13. | ALA4724665 | Binding | Protac activity at CRBN/IRAK4 in human OCILY10 cells harboring MYD88 L265P mutant assessed as induction of IRAK4 degradation at 1 uM pretreated with proteasome inhibitor, MG132 for 2 hrs followed by compound addition by Western blot analysis | Homo sapiens | 1 | ALA4715903 | cell-based format | Scientific Literature | |
14. | ALA4724666 | Binding | Protac activity at CRBN/IRAK4 in human TMD8 cells harboring MYD88 L265P mutant assessed as induction of IRAK4 degradation by measuring reduction in IRAK4 protein level at 1 uM by Western blot analysis | Homo sapiens | 1 | ALA4715903 | cell-based format | Scientific Literature | |
15. | ALA4724667 | Binding | Protac activity at CRBN/IRAK4 in human OCILY10 cells harboring MYD88 L265P mutant assessed as induction of IRAK4 degradation by measuring reduction in IRAK4 protein level at 1 uM by Western blot analysis | Homo sapiens | 1 | ALA4715903 | cell-based format | Scientific Literature | |
16. | ALA4724668 | Binding | Protac activity at CRBN/IRAK4 in human TMD8 cells harboring MYD88 L265P mutant assessed as induction of IRAK4 degradation by measuring reduction in IRAK4 protein level incubated for 24 hrs by Western blot analysis | Homo sapiens | 1 | ALA4715903 | cell-based format | Scientific Literature | |
17. | ALA4724669 | Binding | Protac activity at CRBN/IRAK4 in human OCILY10 cells harboring MYD88 L265P mutant assessed as induction of IRAK4 degradation by measuring reduction in IRAK4 protein level incubated for 24 hrs by Western blot analysis | Homo sapiens | 1 | ALA4715903 | cell-based format | Scientific Literature | |
18. | ALA4724670 | Binding | Protac activity at CRBN/IRAK4 in human TMD8 cells harboring MYD88 L265P mutant assessed as induction of IRAK4 degradation by measuring reduction in IRAK4 protein level at 1 uM incubated for 24 hrs by Western blot analysis | Homo sapiens | 9 | ALA4715903 | cell-based format | Scientific Literature | |
19. | ALA4724671 | Binding | Protac activity at CRBN/IRAK4 in human OCILY10 cells harboring MYD88 L265P mutant assessed as induction of IRAK4 degradation by measuring reduction in IRAK4 protein level at 1 uM incubated for 24 hrs by Western blot analysis | Homo sapiens | 9 | ALA4715903 | cell-based format | Scientific Literature | |
20. | ALA4724672 | Binding | Protac activity at CRBN/IRAK4 in human OCILY10 cells assessed as inhibition of NFkappaB p65 phosphorylation at 2.5 to 20 uM incubated for 48 hrs by Western blot analysis | Homo sapiens | 2 | ALA4715903 | cell-based format | Scientific Literature |