| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5249937 | B | Protac activity at VHL/ER alpha in human MCF7 cells assessed as degradation of ER alpha incubated for 6 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 2. | ALA4308525 | B | Induction of VHL E3 ligase mediated ERalpha degradation in human MCF7 cells assessed as downregulation of ERalpha expression by cell-based immunofluorescence assay | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 3. | ALA4308526 | B | Induction of VHL E3 ligase mediated ERalpha degradation in human MCF7 cells at 0.3 uM by cell-based immunofluorescence assay | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
| 4. | ALA4707662 | B | Protac activity at VHL/ERalpha in human MCF7 cells assessed as degradation of ERalpha protein level at 10 uM after 12 hrs by Western blot analysis | 6 | cell-based format | Scientific Literature | |||
| 5. | ALA4707663 | B | Protac activity at VHL/ERalpha in human MCF7 cells assessed as degradation of ERalpha protein level by Western blot analysis | 1 | cell-based format | Scientific Literature | |||
| 6. | ALA4707664 | B | Protac activity at VHL/ERalpha in human A2780 cells assessed as degradation of ERalpha protein level at 10 uM after 12 hrs by Western blot analysis | 1 | cell-based format | Scientific Literature | |||
| 7. | ALA4707682 | B | Protac activity at VHL/ERalpha in human MCF7 cells assessed as increase in ubiquitinated-ERalpha at 10 uM after 6 hrs in presence of MG-132 by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 8. | ALA4709460 | B | Induction of VHL-mediated ERalpha degradation in human MCF7 cells by western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 9. | ALA4709461 | B | Induction of VHL-mediated ERalpha degradation in human MCF7 cells assessed as maximum degradation by western blot analysis relative to control | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 10. | ALA4709462 | B | Induction of VHL-mediated ERalpha degradation in human T47D cells by western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 11. | ALA4709463 | B | Induction of VHL-mediated ERalpha degradation in human T47D cells assessed as maximum degradation by western blot analysis relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 12. | ALA4726576 | B | Protac activity at VHL/ERalpha in human MCF7 cells assessed as induction of ERalpha protein degradation incubated for 8 to 24 hrs by western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 13. | ALA4726590 | B | Protac activity at VHL/ERalpha in human MCF7 cells assessed as induction of ERalpha protein degradation by measuring ERalpha protein level at 5 uM incubated for 8 hrs by western blot analysis relative to lamin B | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 14. | ALA4726591 | B | Protac activity at VHL/ERalpha in human MCF7 cells assessed as induction of ERalpha protein degradation by measuring ERalpha protein level at 10 uM incubated for 8 hrs by western blot analysis relative to lamin B | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 15. | ALA4726592 | B | Protac activity at VHL/ERalpha in human MCF7 cells assessed as induction of ERalpha protein degradation by measuring ERalpha protein level at 20 uM incubated for 8 hrs by western blot analysis relative to lamin B | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 16. | ALA4726608 | B | Protac activity at VHL/ERalpha in human MCF7 cells assessed as induction of ERalpha protein degradation by measuring ERalpha protein level at 5 uM incubated for 24 hrs by western blot analysis relative to lamin B | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 17. | ALA4726609 | B | Protac activity at VHL/ERalpha in human MCF7 cells assessed as induction of ERalpha protein degradation by measuring ERalpha protein level at 10 uM incubated for 24 hrs by western blot analysis relative to lamin B | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 18. | ALA4726610 | B | Protac activity at VHL/ERalpha in human MCF7 cells assessed as induction of ERalpha protein degradation by measuring ERalpha protein level at 20 uM incubated for 24 hrs by western blot analysis relative to lamin B | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 19. | ALA4726639 | B | Protac activity at VHL/ERalpha in human MCF7 cells assessed as induction of ERalpha protein degradation by measuring ERalpha protein level at 20 uM incubated for 8 hrs in presence of proteasome inhibitor, MG132 by western blot analysis relative to lamin B | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 20. | ALA4726642 | B | Protac activity at VHL/ERalpha in human MCF7 cells assessed as induction of ERalpha protein degradation by measuring ERalpha protein level at 20 uM incubated for 8 hrs in presence of ubiquitin activating inhibitor MLN7243 by western blot analysis relative to lamin B | Homo sapiens | 1 | cell-based format | Scientific Literature |
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