| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4324990 | B | Protac activity against VHL/AR in AR-positive human LNCAP cells assessed as reduction in PSA mRNA expression level incubated for 24 hrs by qRT-PCR analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 2. | ALA4324991 | B | Protac activity against VHL/AR in AR-positive human LNCAP cells assessed as induction of AR degradation at 0.01 uM incubated for 6 hrs by Western blot analysis relative to control | Homo sapiens | 22 | cell-based format | Scientific Literature | ||
| 3. | ALA4324992 | B | Protac activity against VHL/AR in AR-positive human LNCAP cells assessed as induction of AR degradation at 0.1 uM incubated for 6 hrs by Western blot analysis relative to control | Homo sapiens | 22 | cell-based format | Scientific Literature | ||
| 4. | ALA4324993 | B | Protac activity against VHL/AR in AR-positive human LNCAP cells assessed as induction of AR degradation at 1 uM incubated for 6 hrs by Western blot analysis relative to control | Homo sapiens | 22 | cell-based format | Scientific Literature | ||
| 5. | ALA4324994 | B | Protac activity against VHL/AR in AR-positive human LNCAP cells assessed as induction of AR degradation by measuring reduction in AR protein level at 100 nM incubated for 3 hrs by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 6. | ALA4324995 | B | Protac activity against VHL/AR in AR-positive human VCaP cells assessed as induction of AR degradation by measuring reduction in AR protein level at 100 nM incubated for 3 hrs by Western blot analysis relative to control | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 7. | ALA4324996 | B | Protac activity against VHL/AR in AR-positive human LNCAP cells assessed as induction of AR degradation incubated for 6 hrs by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 8. | ALA4324997 | B | Protac activity against VHL/AR in AR-positive human VCaP cells assessed as induction of AR degradation incubated for 6 hrs by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 9. | ALA4324998 | B | Protac activity against VHL/AR in AR-positive human 22Rv1 cells assessed as induction of AR degradation incubated for 6 hrs by Western blot analysis | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 10. | ALA4324999 | B | Protac activity against VHL/AR in AR-positive human LNCAP cells assessed as induction of AR degradation by measuring reduction in AR protein level at 30 nM incubated for 6 hrs by Western blot analysis relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 11. | ALA4325000 | B | Protac activity against VHL/AR in AR-positive human VCaP cells assessed as induction of AR degradation by measuring reduction in AR protein level at 30 nM incubated for 6 hrs by Western blot analysis relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 12. | ALA4325001 | B | Protac activity against VHL/AR in AR-positive human 22Rv1 cells assessed as induction of AR degradation by measuring reduction in AR protein level at 10 nM incubated for 6 hrs by Western blot analysis relative to control | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 13. | ALA4325002 | B | Protac activity against VHL/AR in AR-positive human LNCAP cells assessed as AR degradation at 100 nM preincubated with VHL ligand VHLa for 2 hrs followed by incubation with compound for 6 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 14. | ALA4325003 | B | Protac activity against VHL/AR in AR-positive human LNCAP cells assessed as AR degradation at 100 nM preincubated with NEDD8-activating E1 enzyme inhibitor, MLN4924 for 2 hrs followed by incubation with compound for 6 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 15. | ALA4325004 | B | Protac activity against VHL/AR in AR-positive human LNCAP cells assessed as AR degradation at 100 nM preincubated with proteasome inhibitor, MG132 for 2 hrs followed by incubation with compound for 6 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 16. | ALA4325005 | B | Protac activity against VHL/AR in AR-positive human LNCAP cells assessed as reduction in TMPRSS2 mRNA expression level incubated for 24 hrs by qRT-PCR analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 17. | ALA4325006 | B | Protac activity against VHL/AR in AR-positive human LNCAP cells assessed as reduction in FKBP5 mRNA expression level incubated for 24 hrs by qRT-PCR analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 18. | ALA4325007 | B | Protac activity against VHL/AR in AR-positive human LNCAP cells assessed as reduction in PSA mRNA expression level at 10 nM incubated for 24 hrs by qRT-PCR analysis relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 19. | ALA4325008 | B | Protac activity against VHL/AR in AR-positive human LNCAP cells assessed as reduction in TMPRSS2 mRNA expression level at 10 nM incubated for 24 hrs by qRT-PCR analysis relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 20. | ALA4325009 | B | Protac activity against VHL/AR in AR-positive human LNCAP cells assessed as reduction in FKBP5 mRNA expression level at 10 nM incubated for 24 hrs by qRT-PCR analysis relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature |
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