| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4324543 | B | Protac activity against VHL/MEK2 in human HT-29 cells harboring BRAF V600E variant assessed as degradation of MEK2 at 0.3 to 3 uM after 24 hrs by Western blot analysis | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 2. | ALA4324549 | B | Protac activity against VHL/MEK2 in human HT-29 cells harboring BRAF V600E variant assessed as degradation of MEK2 after 24 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 3. | ALA4324551 | B | Protac activity against VHL/MEK2 in human SK-MEL-28 cells harboring BRAF V600E variant assessed as degradation of MEK2 after 24 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 4. | ALA4324553 | B | Protac activity against VHL/MEK2 in human COLO205 cells harboring BRAF V600E variant assessed as degradation of MEK2 after 24 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 5. | ALA4324555 | B | Protac activity against VHL/MEK2 in human UACC257 cells harboring BRAF V600E variant assessed as degradation of MEK2 after 24 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 6. | ALA4324557 | B | Protac activity against VHL/MEK2 in human HT-29 cells harboring BRAF V600E variant assessed as degradation of MEK2 by measuring reduction in MEK2 protein level at 0.5 uM after 24 hrs by Western blot analysis relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 7. | ALA4324559 | B | Protac activity against VHL/MEK2 in human SK-MEL-28 cells harboring with BRAF V600E variant assessed as degradation of MEK2 by measuring reduction in MEK2 protein level at 0.3 uM after 24 hrs by Western blot analysis relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 8. | ALA4324561 | B | Protac activity against VHL/MEK2 in human HT-29 cells harboring with BRAF V600E variant assessed as degradation of MEK2 at 3 to 5 uM after 24 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 9. | ALA4324563 | B | Protac activity against VHL/MEK2 in human SK-MEL-28 cells harboring with BRAF V600E variant assessed as degradation of MEK2 at 3 to 5 uM after 24 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 10. | ALA4324565 | B | Protac activity against VHL/MEK2 in human COLO205 cells harboring with BRAF V600E variant assessed as degradation of MEK2 at 3 to 5 uM after 24 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 11. | ALA4324567 | B | Protac activity against VHL/MEK2 in human UACC257 cells harboring with BRAF V600E variant assessed as degradation of MEK2 at 3 to 5 uM after 24 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 12. | ALA4324581 | B | Protac activity against VHL/MEK2 in human HT-29 cells harboring with BRAF V600E variant assessed as degradation of MEK2 by measuring MEK2 protein level up to 1 uM after 24 hrs by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 13. | ALA4324583 | B | Protac activity against VHL/MEK2 in human SK-MEL-28 cells harboring with BRAF V600E variant assessed as degradation of MEK2 by measuring MEK2 protein level up to 1 uM after 24 hrs by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 14. | ALA4324589 | B | Protac activity against VHL/MEK2 in human HT-29 cells harboring with BRAF V600E variant assessed as degradation of MEK2 by measuring reduction in MEK2 protein level at 0.1 to 0.3 uM after 2 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 15. | ALA4324591 | B | Protac activity against VHL/MEK2 in human SK-MEL-28 cells harboring with BRAF V600E variant assessed as degradation of MEK2 by measuring reduction in MEK2 protein level at 0.1 to 0.3 uM after 2 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 16. | ALA4324597 | B | Protac activity against VHL/MEK2 in human HT-29 cells harboring with BRAF V600E variant assessed as degradation of MEK2 at 0.1 to 0.3 uM after 4 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 17. | ALA4324599 | B | Protac activity against VHL/MEK2 in human SK-MEL-28 cells harboring with BRAF V600E variant assessed as degradation of MEK2 at 0.1 to 0.3 uM after 4 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 18. | ALA4324605 | B | Protac activity against VHL/MEK2 in human HT-29 cells harboring with BRAF V600E variant assessed as degradation of MEK2 at 0.3 uM after 3 to 144 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 19. | ALA4324611 | B | Protac activity against VHL/MEK2 in human HT-29 cells harboring with BRAF V600E variant assessed as degradation of MEK2 by measuring MEK2 protein level at 0.3 uM pretreated with MEK1/2 inhibitor, PD0325901 for 2 hrs followed by incubation with compound for 10 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 20. | ALA4324613 | B | Protac activity against VHL/MEK2 in human SK-MEL-28 cells harboring with BRAF V600E variant assessed as degradation of MEK2 by measuring MEK2 protein level at 0.3 uM pretreated with MEK1/2 inhibitor, PD0325901 for 2 hrs followed by incubation with compound for 10 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature |
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