# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4388601 | Binding | Protac activity at VHL/FLT3 in human MOLM14 cells assessed as induction of FLT3 protein degradation measured after 4 hrs by immunoblot analysis | Homo sapiens | 1 | ALA4387721 | cell-based format | Scientific Literature | |
2. | ALA4388602 | Binding | Protac activity at VHL/FLT3 in human MOLM14 cells assessed as induction of FLT3 protein degradation at 50 nM measured after 4 hrs by immunoblot analysis relative to control | Homo sapiens | 1 | ALA4387721 | cell-based format | Scientific Literature | |
3. | ALA4686168 | Binding | Protac activity at VHL/FLT3 in human SR cells assessed as induction of FLT3 degradation | Homo sapiens | 1 | ALA4680228 | cell-based format | Scientific Literature | |
4. | ALA5152838 | Binding | PROTAC activity at VHL/FLT-3 in human HL-60 cells assessed as reduction in FLT-3 protein level at 10 to 20 uM incubated for 48 hrs by Western blot analysis | Homo sapiens | 1 | ALA5150032 | cell-based format | Scientific Literature | |
5. | ALA5152839 | Binding | PROTAC activity at VHL/FLT-3 in human HL-60 cells assessed as reduction in FLT-3 protein level at 10 uM incubated for 12 hrs by Western blot analysis | Homo sapiens | 1 | ALA5150032 | cell-based format | Scientific Literature | |
6. | ALA5152840 | Binding | PROTAC activity at VHL/FLT-3 in human HL-60 cells assessed as reduction in FLT-3 protein level at 10 uM by Western blot analysis | Homo sapiens | 1 | ALA5150032 | cell-based format | Scientific Literature | |
7. | ALA5152842 | Binding | PROTAC activity at VHL/FLT-3 in human K562 cells assessed as reduction in FLT-3 protein level at 20 uM incubated for 48 hrs by Western blot analysis | Homo sapiens | 2 | ALA5150032 | cell-based format | Scientific Literature | |
8. | ALA5152843 | Binding | PROTAC activity at VHL/FLT-3 in human HL-60 cells assessed as reduction in FLT-3 protein level at 1 uM incubated for 1 hrs by Western blot analysis | Homo sapiens | 1 | ALA5150032 | cell-based format | Scientific Literature | |
9. | ALA5152844 | Binding | PROTAC activity at VHL/FLT-3 in human HL-60 cells assessed as reduction in FLT-3 protein level at 1 uM incubated for 48 hrs by Western blot analysis | Homo sapiens | 1 | ALA5150032 | cell-based format | Scientific Literature | |
10. | ALA5152845 | Binding | PROTAC activity at VHL/FLT-3 in human HL-60 cells assessed as reduction in FLT-3 protein level at 20 uM incubated for 24 hrs by Western blot analysis | Homo sapiens | 1 | ALA5150032 | cell-based format | Scientific Literature | |
11. | ALA5152846 | Binding | PROTAC activity at VHL/FLT-3 in human HL-60 cells assessed as reduction in FLT-3 protein level at 20 uM preincubated with MG-132 for 1 hrs followed by compound addition and measured after for 48 hrs by Western blot analysis | Homo sapiens | 1 | ALA5150032 | cell-based format | Scientific Literature | |
12. | ALA5152847 | Binding | PROTAC activity at VHL/FLT-3 in human HL-60 cells assessed as reduction in FLT-3 protein level at 20 uM preincubated with VHL032 for 1 hrs followed by compound addition and measured after for 48 hrs by Western blot analysis | Homo sapiens | 1 | ALA5150032 | cell-based format | Scientific Literature |