| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4324542 | B | Protac activity against VHL/MEK1 in human HT-29 cells harboring BRAF V600E variant assessed as degradation of MEK1 at 0.3 to 3 uM after 24 hrs by Western blot analysis | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 2. | ALA4324548 | B | Protac activity against VHL/MEK1 in human HT-29 cells harboring BRAF V600E variant assessed as degradation of MEK1 after 24 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 3. | ALA4324550 | B | Protac activity against VHL/MEK1 in human SK-MEL-28 cells harboring BRAF V600E variant assessed as degradation of MEK1 after 24 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 4. | ALA4324552 | B | Protac activity against VHL/MEK1 in human COLO205 cells harboring BRAF V600E variant assessed as degradation of MEK1 after 24 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 5. | ALA4324554 | B | Protac activity against VHL/MEK1 in human UACC257 cells harboring BRAF V600E variant assessed as degradation of MEK1 after 24 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 6. | ALA4324556 | B | Protac activity against VHL/MEK1 in human HT-29 cells harboring with BRAF V600E variant assessed as degradation of MEK1 by measuring reduction in MEK1 protein level at 0.5 uM after 24 hrs by Western blot analysis relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 7. | ALA4324558 | B | Protac activity against VHL/MEK1 in human SK-MEL-28 cells harboring with BRAF V600E variant assessed as degradation of MEK1 by measuring reduction in MEK1 protein level at 0.3 uM after 24 hrs by Western blot analysis relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 8. | ALA4324560 | B | Protac activity against VHL/MEK1 in human HT-29 cells harboring with BRAF V600E variant assessed as degradation of MEK1 at 3 to 5 uM after 24 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 9. | ALA4324562 | B | Protac activity against VHL/MEK1 in human SK-MEL-28 cells harboring with BRAF V600E variant assessed as degradation of MEK1 at 3 to 5 uM after 24 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 10. | ALA4324564 | B | Protac activity against VHL/MEK1 in human COLO205 cells harboring with BRAF V600E variant assessed as degradation of MEK1 at 3 to 5 uM after 24 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 11. | ALA4324566 | B | Protac activity against VHL/MEK1 in human UACC257 cells harboring with BRAF V600E variant assessed as degradation of MEK1 at 3 to 5 uM uM after 24 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 12. | ALA4324580 | B | Protac activity against VHL/MEK1 in human HT-29 cells harboring with BRAF V600E variant assessed as degradation of MEK1 by measuring MEK1 protein level up to 1 uM after 24 hrs by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 13. | ALA4324582 | B | Protac activity against VHL/MEK1 in human SK-MEL-28 cells harboring with BRAF V600E variant assessed as degradation of MEK1 by measuring MEK1 protein level up to 1 uM after 24 hrs by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 14. | ALA4324588 | B | Protac activity against VHL/MEK1 in human HT-29 cells harboring with BRAF V600E variant assessed as degradation of MEK1 by measuring reduction in MEK1 protein level at 0.1 to 0.3 uM after 2 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 15. | ALA4324590 | B | Protac activity against VHL/MEK1 in human SK-MEL-28 cells harboring with BRAF V600E variant assessed as degradation of MEK1 by measuring reduction in MEK1 protein level at 0.1 to 0.3 uM after 2 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 16. | ALA4324592 | B | Protac activity against VHL/MEK1 in human HT-29 cells harboring with BRAF V600E variant assessed as degradation of MEK1 by measuring reduction in MEK1 protein level at 0.3 uM after 4 hrs by Western blot analysis relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 17. | ALA4324593 | B | Protac activity against VHL/MEK1 in human SK-MEL-28 cells harboring with BRAF V600E variant assessed as degradation of MEK1 by measuring reduction in MEK1 protein level at 0.3 uM after 4 hrs by Western blot analysis relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 18. | ALA4324594 | B | Protac activity against VHL/MEK1 in human HT-29 cells harboring with BRAF V600E variant assessed as degradation of MEK1 by measuring reduction in MEK1 protein level at 0.3 uM after 8 hrs by Western blot analysis relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 19. | ALA4324595 | B | Protac activity against VHL/MEK1 in human SK-MEL-28 cells harboring with BRAF V600E variant assessed as degradation of MEK1 by measuring reduction in MEK1 protein level at 0.3 uM after 8 hrs by Western blot analysis relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 20. | ALA4324596 | B | Protac activity against VHL/MEK1 in human HT-29 cells harboring with BRAF V600E variant assessed as degradation of MEK1 at 0.1 to 0.3 uM after 4 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature |
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