| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4361879 | B | Protac activity at VHL/IRAK4 in human PBMC assessed as induction of degradation of IRAK4 incubated for 24 hrs by Western blot analysis | Homo sapiens | 2 | protein format | Scientific Literature | ||
| 2. | ALA4361880 | B | Protac activity at VHL/IRAK4 in human PBMC assessed as induction of degradation of IRAK4 at 3 uM incubated for 24 hrs by Western blot analysis relative to control | Homo sapiens | 1 | protein format | Scientific Literature | ||
| 3. | ALA4361886 | B | Protac activity at VHL/IRAK4 in human epoxomicin PBMC assessed as increase in p21 accumulation at 0.01 to 10 uM incubated for 22 hrs by Western blot analysis | Homo sapiens | 1 | protein format | Scientific Literature | ||
| 4. | ALA4361887 | B | Protac activity at VHL/IRAK4 in human PBMC assessed as reduction in R848-stimulated IL-1beta level preincubated for 18 hrs followed by R848-stimulation and measured after 8 hrs by MSD assay | Homo sapiens | 2 | protein format | Scientific Literature | ||
| 5. | ALA4361888 | B | Protac activity at VHL/IRAK4 in human PBMC assessed as reduction in R848-stimulated IFNgamma preincubated for 18 hrs followed by R848 stimulation and measured after 8 hrs by MSD assay | Homo sapiens | 2 | protein format | Scientific Literature | ||
| 6. | ALA4361889 | B | Protac activity at VHL/IRAK4 in human PBMC assessed as reduction in R848-stimulated IL-6 level preincubated for 18 hrs followed by R848 stimulation and measured after 8 hrs by MSD assay | Homo sapiens | 2 | protein format | Scientific Literature | ||
| 7. | ALA4361890 | B | Protac activity at VHL/IRAK4 in human PBMC assessed as reduction in R848-stimulated IL-8 level preincubated for 18 hrs followed by R848 stimulation and measured after 8 hrs by MSD assay | Homo sapiens | 2 | protein format | Scientific Literature | ||
| 8. | ALA4361891 | B | Protac activity at VHL/IRAK4 in human PBMC assessed as reduction in R848-stimulated IL-10 level preincubated for 18 hrs followed by R848 stimulation and measured after 8 hrs by MSD assay | Homo sapiens | 2 | protein format | Scientific Literature | ||
| 9. | ALA4361892 | B | Protac activity at VHL/IRAK4 in human PBMC assessed as reduction in R848-stimulated TNFalpha level preincubated for 18 hrs followed by R848 stimulation and measured after 8 hrs by MSD assay | Homo sapiens | 2 | protein format | Scientific Literature | ||
| 10. | ALA4361893 | B | Protac activity at VHL/IRAK4 in human dermal fibroblast assessed as induction of degradation of IRAK4 incubated for 24 hrs by Western blot analysis | Homo sapiens | 1 | protein format | Scientific Literature | ||
| 11. | ALA4361894 | B | Protac activity at VHL/IRAK4 in human dermal fibroblast assessed as reduction in IL-1beta stimulated IL-6 level at 300 nM incubated for 18 hrs followed by IL-1beta stimulation further incubated for 8 hrs by MSD assay | Homo sapiens | 2 | protein format | Scientific Literature | ||
| 12. | ALA4361895 | B | Protac activity at VHL/IRAK4 in human PBMC assessed as induction of degradation of IRAK4 incubated for 24 hrs by Western blot analysis relative to control | Homo sapiens | 1 | protein format | Scientific Literature | ||
| 13. | ALA4361899 | B | Protac activity at VHL/IRAK4 in human THP-1 cells assessed as induction of degradation of IRAK4 at 0.1 to 10 uM incubated for 24 hrs by Western blot analysis | Homo sapiens | 7 | cell-based format | Scientific Literature | ||
| 14. | ALA4361900 | B | Protac activity at VHL/IRAK4 in human PBMC assessed as remaining IRAK4 level at 100 nM incubated for 24 hrs by Western blot analysis relative to control | Homo sapiens | 1 | protein format | Scientific Literature | ||
| 15. | ALA4361901 | B | Protac activity at VHL/IRAK4 in human PBMC assessed as remaining IRAK4 level at 300 nM incubated for 24 hrs by Western blot analysis relative to control | Homo sapiens | 1 | protein format | Scientific Literature | ||
| 16. | ALA4361902 | B | Protac activity at VHL/IRAK4 in human PBMC assessed as remaining IRAK4 level at 1 uM incubated for 24 hrs by Western blot analysis relative to control | Homo sapiens | 1 | protein format | Scientific Literature | ||
| 17. | ALA4361903 | B | Protac activity at VHL/IRAK4 in human PBMC assessed as remaining IRAK4 level at 10 uM incubated for 24 hrs by Western blot analysis relative to control | Homo sapiens | 1 | protein format | Scientific Literature | ||
| 18. | ALA4361904 | B | Protac activity at VHL/IRAK4 in human epoxomicin pretreated PBMC assessed as induction of degradation of IRAK4 at 0.01 to 10 uM incubated for 22 hrs by Western blot analysis | Homo sapiens | 1 | protein format | Scientific Literature |
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