# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4382070 | Binding | Protac activity at CRBN/ABL in human K562 cells assessed as reduction in ABL protein levels at 100 nM incubated for 36 hrs by Western blot analysis | Homo sapiens | 2 | ALA4376901 | cell-based format | Scientific Literature | |
2. | ALA4382082 | Binding | Protac activity at CRBN/ABL in human K562 cells assessed as reduction in ABL protein levels pre-treated with ABL inhibitor dasatinib followed by compound addition at 250 nM incubated for 24 hrs by Western blot analysis | Homo sapiens | 1 | ALA4376901 | cell-based format | Scientific Literature | |
3. | ALA4382084 | Binding | Protac activity at CRBN/ABL in human K562 cells assessed as reduction in ABL protein levels at 50 to 250 nM incubated for 24 hrs by Western blot analysis | Homo sapiens | 1 | ALA4376901 | cell-based format | Scientific Literature | |
4. | ALA4382086 | Binding | Protac activity at CRBN/ABL in human K562 cells assessed as reduction in ABL protein levels pre-treated with lenalidomide followed by compound addition at 250 nM incubated for 24 hrs by Western blot analysis | Homo sapiens | 1 | ALA4376901 | cell-based format | Scientific Literature | |
5. | ALA4382088 | Binding | Protac activity at CRBN/ABL in human K562 cells assessed as reduction in ABL protein levels pre-treated with NEDD8-activating enzyme (NAE) inhibitor MLN4924 followed by compound addition at 250 nM incubated for 24 hrs by Western blot analysis | Homo sapiens | 1 | ALA4376901 | cell-based format | Scientific Literature | |
6. | ALA4382090 | Binding | Protac activity at CRBN/ABL in human K562 cells assessed as reduction in ABL protein levels incubated for 36 hrs by Western blot analysis | Homo sapiens | 1 | ALA4376901 | cell-based format | Scientific Literature | |
7. | ALA4382092 | Binding | Protac activity at CRBN/ABL in human K562 cells assessed as reduction in ABL protein levels at 500 nM incubated for 36 hrs by Western blot analysis | Homo sapiens | 1 | ALA4376901 | cell-based format | Scientific Literature | |
8. | ALA4382094 | Binding | Protac activity at CRBN/ABL in human K562 cells assessed as reduction in ABL protein levels at 250 nM incubated for 4 hrs by Western blot analysis | Homo sapiens | 1 | ALA4376901 | cell-based format | Scientific Literature | |
9. | ALA4382096 | Binding | Protac activity at CRBN/ABL in human K562 cells assessed as reduction in ABL protein levels at 250 nM incubated for 10 hrs by Western blot analysis | Homo sapiens | 1 | ALA4376901 | cell-based format | Scientific Literature | |
10. | ALA4382098 | Binding | Protac activity at CRBN/ABL in human K562 cells assessed as reduction in ABL protein levels at 250 nM incubated for 32 hrs by Western blot analysis | Homo sapiens | 2 | ALA4376901 | cell-based format | Scientific Literature | |
11. | ALA4382101 | Binding | Protac activity at CRBN/ABL in human K562 cells assessed as reduction in ABL protein levels incubated for 24 hrs followed by exposure to UV-C light every 4 hrs by Western blot analysis | Homo sapiens | 1 | ALA4376901 | cell-based format | Scientific Literature | |
12. | ALA4382103 | Binding | Protac activity at CRBN/ABL in human K562 cells assessed as reduction in ABL protein levels incubated for 24 hrs followed by exposure to white light up to 24 hrs by Western blot analysis | Homo sapiens | 2 | ALA4376901 | cell-based format | Scientific Literature |