| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4324568 | B | Protac activity against VHL/MEK1/2 in human HT-29 cells harboring with BRAF V600E variant assessed as reduction in phosphorylation of MEK at S218/222 residues after 24 hrs by Western blot analysis | Homo sapiens | 1 | ALA4321854 | cell-based format | Scientific Literature | |
| 2. | ALA4324569 | B | Protac activity against VHL/MEK1/2 in human SK-MEL-28 cells harboring with BRAF V600E variant assessed as reduction in phosphorylation of MEK at S218/222 residues after 24 hrs by Western blot analysis | Homo sapiens | 1 | ALA4321854 | cell-based format | Scientific Literature | |
| 3. | ALA4324570 | B | Protac activity against VHL/MEK1/2 in human COLO205 cells harboring with BRAF V600E variant assessed as reduction in phosphorylation of MEK at S218/222 residues after 24 hrs by Western blot analysis | Homo sapiens | 1 | ALA4321854 | cell-based format | Scientific Literature | |
| 4. | ALA4324571 | B | Protac activity against VHL/MEK1/2 in human UACC257 cells harboring with BRAF V600E variant assessed as reduction in phosphorylation of MEK at S218/222 residues after 24 hrs by Western blot analysis | Homo sapiens | 1 | ALA4321854 | cell-based format | Scientific Literature | |
| 5. | ALA4324572 | B | Protac activity against VHL/MEK1/2 in human HT-29 cells harboring with BRAF V600E variant assessed as reduction in phosphorylation of ERK at T202/Y204 residues after 24 hrs by Western blot analysis | Homo sapiens | 1 | ALA4321854 | cell-based format | Scientific Literature | |
| 6. | ALA4324573 | B | Protac activity against VHL/MEK1/2 in human SK-MEL-28 cells harboring with BRAF V600E variant assessed as reduction in phosphorylation of ERK at T202/Y204 residues after 24 hrs by Western blot analysis | Homo sapiens | 1 | ALA4321854 | cell-based format | Scientific Literature | |
| 7. | ALA4324574 | B | Protac activity against VHL/MEK1/2 in human COLO205 cells harboring with BRAF V600E variant assessed as reduction in phosphorylation of ERK at T202/Y204 residues after 24 hrs by Western blot analysis | Homo sapiens | 1 | ALA4321854 | cell-based format | Scientific Literature | |
| 8. | ALA4324575 | B | Protac activity against VHL/MEK1/2 in human UACC257 cells harboring with BRAF V600E variant assessed as reduction in phosphorylation of ERK at T202/Y204 residues after 24 hrs by Western blot analysis | Homo sapiens | 1 | ALA4321854 | cell-based format | Scientific Literature | |
| 9. | ALA4324600 | B | Protac activity against VHL/MEK1/2 in human HT-29 cells harboring with BRAF V600E variant assessed as reduction in phosphorylation of MEK at S218/222 residues at 0.1 to 0.3 after >= 2 hrs by Western blot analysis | Homo sapiens | 1 | ALA4321854 | cell-based format | Scientific Literature | |
| 10. | ALA4324601 | B | Protac activity against VHL/MEK1/2 in human SK-MEL-28 cells harboring with BRAF V600E variant assessed as reduction in phosphorylation of MEK at S218/222 residues at 0.1 to 0.3 after >= 2 hrs by Western blot analysis | Homo sapiens | 1 | ALA4321854 | cell-based format | Scientific Literature | |
| 11. | ALA4324602 | B | Protac activity against VHL/MEK1/2 in human HT-29 cells harboring with BRAF V600E variant assessed as reduction in phosphorylation of ERK at T202/Y204 residues at 0.1 to 0.3 uM by Western blot analysis | Homo sapiens | 1 | ALA4321854 | cell-based format | Scientific Literature | |
| 12. | ALA4324603 | B | Protac activity against VHL/MEK1/2 in human SK-MEL-28 cells harboring with BRAF V600E variant assessed as reduction in phosphorylation of ERK at T202/Y204 residues at 0.1 to 0.3 uM by Western blot analysis | Homo sapiens | 1 | ALA4321854 | cell-based format | Scientific Literature | |
| 13. | ALA4324608 | B | Protac activity against VHL/MEK1/2 in human HT-29 cells harboring with BRAF V600E variant assessed as reduction in phosphorylation of ERK at T202/Y204 residues at 0.3 uM after 24 to 144 hrs by Western blot analysis | Homo sapiens | 1 | ALA4321854 | cell-based format | Scientific Literature | |
| 14. | ALA4324609 | B | Protac activity against VHL/MEK1/2 in human HT-29 cells harboring with BRAF V600E variant assessed as reduction in phosphorylation of MEK at S218/222 residues at 0.3 uM incubated for 6 days by Western blot analysis | Homo sapiens | 1 | ALA4321854 | cell-based format | Scientific Literature | |
| 15. | ALA4324614 | B | Protac activity against VHL/MEK1/2 in human HT-29 cells harboring with BRAF V600E variant assessed as phosphorylation of MEK at S218/222 residues at 0.3 uM pretreated with MEK1/2 inhibitor, PD0325901 for 2 hrs followed by incubation with compound for 2 hrs by Western blot analysis | Homo sapiens | 1 | ALA4321854 | cell-based format | Scientific Literature | |
| 16. | ALA4324615 | B | Protac activity against VHL/MEK1/2 in human SK-MEL-28 cells harboring with BRAF V600E variant assessed as phosphorylation of MEK at S218/222 residues at 0.3 uM pretreated with MEK1/2 inhibitor, PD0325901 for 2 hrs followed by incubation with compound for 2 hrs by Western blot analysis | Homo sapiens | 1 | ALA4321854 | cell-based format | Scientific Literature | |
| 17. | ALA4324616 | B | Protac activity against VHL/MEK1/2 in human HT-29 cells harboring with BRAF V600E variant assessed as phosphorylation of ERK at T202/Y204 residues at 0.3 uM pretreated with MEK1/2 inhibitor, PD0325901 for 2 hrs followed by incubation with compound for 10 hrs by Western blot analysis | Homo sapiens | 1 | ALA4321854 | cell-based format | Scientific Literature | |
| 18. | ALA4324617 | B | Protac activity against VHL/MEK1/2 in human SK-MEL-28 cells harboring with BRAF V600E variant assessed as phosphorylation of ERK at T202/Y204 residues at 0.3 uM pretreated with MEK1/2 inhibitor, PD0325901 for 2 hrs followed by incubation with compound for 10 hrs by Western blot analysis | Homo sapiens | 1 | ALA4321854 | cell-based format | Scientific Literature | |
| 19. | ALA4324622 | B | Protac activity against VHL/MEK1/2 in human HT-29 cells harboring with BRAF V600E variant assessed as phosphorylation of MEK at S218/222 residues at 0.3 uM pretreated with VHL ligand, VH 032 for 2 hrs followed by incubation with compound for 10 hrs by Western blot analysis | Homo sapiens | 1 | ALA4321854 | cell-based format | Scientific Literature | |
| 20. | ALA4324623 | B | Protac activity against VHL/MEK1/2 in human SK-MEL-28 cells harboring with BRAF V600E variant assessed as in phosphorylation of MEK at S218/222 residues at 0.3 uM pretreated with VHL ligand, VH 032 for 2 hrs followed by incubation with compound for 10 hrs by Western blot analysis | Homo sapiens | 1 | ALA4321854 | cell-based format | Scientific Literature |
The page will load shortly, Thanks for your patience!