# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4420664 | B | Inhibition of LATS in human HaCaT cells assessed as reduction in YAP phosphorylation level incubated for 2 hrs by HTRF assay | Homo sapiens | 244 | cell-based format | Patent Bioactivity Data | ||
2. | ALA4420665 | B | Inhibition of LATS in human HaCaT cells assessed as reduction in YAP nuclear translocation incubated for 24 hrs | Homo sapiens | 244 | cell-based format | Patent Bioactivity Data | ||
3. | ALA4420671 | B | Inhibition of LATS in human JHH5 cells assessed as reduction in YAP phosphorylation level incubated for 2 hrs by HTRF assay | Homo sapiens | 284 | cell-based format | Patent Bioactivity Data | ||
4. | ALA4420680 | B | Inhibition of LATS in human limbal epithelial cells assessed as increase in YAP level at 10 uM incubated for 24 hrs by immunostaining based assay | Homo sapiens | 2 | cell-based format | Patent Bioactivity Data | ||
5. | ALA4420681 | B | Inhibition of LATS in human limbal epithelial cells assessed as reduction in YAP phosphorylation level at 10 uM incubated for 1 hr by Western blot analysis | Homo sapiens | 2 | cell-based format | Patent Bioactivity Data | ||
6. | ALA4420682 | B | Inhibition of LATS in human limbal epithelial cells assessed as induction of limbal stem cell expansion by measuring p63alpha expression at 10 uM measured after 2 weeks by immunohistochemistry | Homo sapiens | 2 | cell-based format | Patent Bioactivity Data | ||
7. | ALA4420683 | B | Inhibition of LATS in human limbal epithelial cells assessed as induction of limbal stem cell expansion by measuring expansion factor ratio at 10 uM measured after 2 weeks by p63alpha expression detection based immunohistochemistry relative to control | Homo sapiens | 18 | cell-based format | Patent Bioactivity Data | ||
8. | ALA4420684 | B | Inhibition of LATS in human limbal epithelial cells assessed as induction of limbal stem cell expansion by measuring measuring ratio of expanded population of cells to population of seeded cells at 10 uM measured after 2 weeks by p63alpha expression detection based immunohistochemistry | Homo sapiens | 18 | cell-based format | Patent Bioactivity Data | ||
9. | ALA4420685 | B | Inhibition of LATS in human limbal epithelial cells assessed as induction of limbal stem cell expansion by measuring p63alpha expression at 10 uM measured after 2 weeks by immunohistochemistry relative to control | Homo sapiens | 18 | cell-based format | Patent Bioactivity Data | ||
10. | ALA4420686 | B | Inhibition of LATS in human limbal epithelial cells assessed as induction of limbal stem cell expansion marker expression by measuring deltaN-p63-alphabetagamma protein expression at 10 uM incubated for 8 to 10 days by immunohistochemistry | Homo sapiens | 2 | cell-based format | Patent Bioactivity Data | ||
11. | ALA4420687 | B | Inhibition of LATS in human limbal epithelial cells assessed as induction of limbal stem cell expansion marker expression by measuring ABCG2 protein expression at 10 uM incubated for 8 to 10 days by immunohistochemistry | Homo sapiens | 2 | cell-based format | Patent Bioactivity Data | ||
12. | ALA4420688 | B | Inhibition of LATS in human limbal epithelial cells assessed as induction of limbal stem cell expansion marker expression by measuring C/EBPdelta protein expression at 10 uM incubated for 8 to 10 days by immunohistochemistry | Homo sapiens | 2 | cell-based format | Patent Bioactivity Data | ||
13. | ALA4420689 | B | Inhibition of LATS in human limbal epithelial cells assessed as induction of cell differentiation into corneal epithelial cells by measuring keratin-12 expression at 10 uM incubated for 8 to 10 days followed by medium change to DMEM medium without serum and compound for further incubation for 4 to 8 days by confocal microscopy | Homo sapiens | 4 | cell-based format | Patent Bioactivity Data | ||
14. | ALA4420692 | B | Inhibition of LATS in human limbal epithelial cells with CRISPR/Cas9-mediated deletion of beta-2-microglobulin gene and HLA A/B/C genes assessed as induction of cell expansion to cell preparation without HLA class-I drivers of immune rejection (Rvb = 21%) | Homo sapiens | 1 | cell-based format | Patent Bioactivity Data | ||
15. | ALA4420695 | B | Inhibition of LATS in human corneal endothelium cells assessed as increase in YAP level at 10 uM incubated for 24 hrs by immunohistochemistry | Homo sapiens | 2 | assay format | Patent Bioactivity Data | ||
16. | ALA4420696 | B | Inhibition of LATS in human corneal endothelium cells assessed as reduction in YAP phosphorylation at 10 uM incubated for 1 hr by Western blot analysis | Homo sapiens | 2 | assay format | Patent Bioactivity Data | ||
17. | ALA4420697 | B | Inhibition of LATS in human corneal endothelium cells assessed as induction of cell proliferation measured every 3 hrs for 10 days | Homo sapiens | 2 | assay format | Patent Bioactivity Data | ||
18. | ALA4420698 | B | Inhibition of LATS in human corneal endothelium cells assessed as induction of cell expansion by measuring ratio of expanded population of cells to population of seeded cells at 10 uM by Sytox orange dye based epifluorescence microscopy | Homo sapiens | 21 | assay format | Patent Bioactivity Data | ||
19. | ALA4420699 | B | Inhibition of LATS in human corneal endothelium cells assessed as induction of cell expansion by measuring cell density at 10 uM by Sytox orange dye based epifluorescence microscopy | Homo sapiens | 21 | assay format | Patent Bioactivity Data | ||
20. | ALA4420700 | B | Inhibition of LATS in human corneal endothelium cells assessed as induction of tight junctions formation by measuring ZO1 expression at 10 uM incubated for 10 days by immunofluorescence staining based confocal microscopy | Homo sapiens | 1 | assay format | Patent Bioactivity Data |