| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4315908 | B | Inhibition of GGtase-2 in human cells assessed as minimum effective dose required for increase in intracellular lambda chain level after 48 hrs by ELISA | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 2. | ALA4315909 | B | Inhibition of GGtase-2 in human cells assessed as minimum effective dose causing => 20% decrease in Rab6 level after 48 hrs by immunoblot analysis | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 3. | ALA4315912 | B | Inhibition of GGtase-2 in human cells assessed as increase in intracellular lambda chain at =< 5 mM level after 48 hrs by ELISA | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 4. | ALA4315913 | B | Inhibition of GGtase-2 in human cells assessed as decrease in Rab6 level at =< 5 mM after 48 hrs by immunoblot analysis relative to control | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 5. | ALA4315916 | B | Inhibition of GGtase-2 in human RPMI8226 cells assessed as increase in intracellular lambda chain at =< 1 mM level after 48 hrs by ELISA | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 6. | ALA4315917 | B | Inhibition of GGtase-2 in human RPMI8226 cells assessed as decrease in Rab6 level at =< 1 mM after 48 hrs by immunoblot analysis relative to control | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 7. | ALA4315920 | B | Inhibition of GGtase-2 in human RPMI8226 cells assessed as increase in intracellular lambda light chain level at 1 to 5 mM incubated for 48 hrs by immunoblot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 8. | ALA4315923 | B | Inhibition of GGtase-2 in human RPMI8226 cells assessed as accumulation of intracellular lambda light chain level at 10 to 100 uM after 48 hrs by immunoblot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 9. | ALA4315930 | B | Inhibition of GGTase-2 in human RPMI8226 cells assessed as ratio of calnexin to Rab6 level at 10 uM after 48 hrs by immunoblot analysis relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 10. | ALA4315931 | B | Inhibition of GGTase-2 in human RPMI8226 cells assessed as ratio of calnexin to Rab6 level at 1 mM after 48 hrs by immunoblot analysis relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 11. | ALA4315932 | B | Inhibition of GGTase-2 in human RPMI8226 cells assessed as ratio of calnexin to Rab6 level at 2.5 mM after 48 hrs by immunoblot analysis relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 12. | ALA4315933 | B | Inhibition of GGTase-2 in human RPMI8226 cells assessed as ratio of calnexin to Rab6 level at 5 mM after 48 hrs by immunoblot analysis relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 13. | ALA4421918 | B | Inhibition of RabGGTase (unknown origin) using YPTI as substrate protein and [3H]geranylgeranyl pyrophosphate incubated for 20 mins by scintillation counting assay | Homo sapiens | 9 | protein complex format | Patent Bioactivity Data | ||
| 14. | ALA4421939 | B | Inhibition of RabGGTase (unknown origin) up to 10000 nM using YPTI as substrate protein and [3H]geranylgeranyl pyrophosphate incubated for 20 mins by scintillation counting assay | Homo sapiens | 1 | protein complex format | Patent Bioactivity Data | ||
| 15. | ALA4421940 | B | Inhibition of RabGGTase (unknown origin) at 50000 nM using YPTI as substrate protein and [3H]geranylgeranyl pyrophosphate incubated for 20 mins by scintillation counting assay | Homo sapiens | 1 | protein complex format | Patent Bioactivity Data | ||
| 16. | ALA4421947 | B | Inhibition of RabGGTase in HEK293 cells assessed as reduction in geranylgeranylation of Rab5b protein at 5 to 10 uM incubated for 48 hrs by SDS-PAGE and immunoblot analysis | Homo sapiens | 1 | cell-based format | Patent Bioactivity Data | ||
| 17. | ALA4421948 | B | Inhibition of RabGGTase in HEK293 cells assessed as reduction in geranylgeranylation of Rab5b protein at 20 uM incubated for 48 hrs by SDS-PAGE and immunoblot analysis | Homo sapiens | 1 | cell-based format | Patent Bioactivity Data | ||
| 18. | ALA4421949 | B | Inhibition of RabGGTase (unknown origin) at 100000 nM using YPTI as substrate protein and [3H]geranylgeranyl pyrophosphate incubated for 20 mins by scintillation counting assay | Homo sapiens | 1 | protein complex format | Patent Bioactivity Data | ||
| 19. | ALA4421965 | B | Inhibition of RabGGTase in HEK293 cells assessed as reduction in geranylgeranylation of Rab5b protein at 5 to 20 uM incubated for 48 hrs by SDS-PAGE and immunoblot analysis | Homo sapiens | 1 | cell-based format | Patent Bioactivity Data | ||
| 20. | ALA4421968 | B | Inhibition of RabGGTase in HEK293 cells assessed as increase in Rab5b protein in soluble fraction at 5 to 20 uM incubated for 48 hrs by SDS-PAGE and immunoblot analysis | Homo sapiens | 1 | cell-based format | Patent Bioactivity Data |
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