| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4361387 | B | Inhibition of PCSK9 (unknown origin) interaction with LDLR expressed in human HepG2 cells assessed as LDLR level on cell membrane at 1 uM measured after 2 hrs by in-cell Western analysis (Rvb = 30.5 to 47.2%) | Homo sapiens | 2 | ALA4359840 | cell-based format | Scientific Literature | |
| 2. | ALA4361388 | B | Inhibition of recombinant His-tagged PCSK9 (unknown origin) binding to recombinant LDRR AB domain (unknown origin) measured after 2 hrs by ELISA | Homo sapiens | 5 | ALA4359840 | protein format | Scientific Literature | |
| 3. | ALA4361389 | B | Inhibition of recombinant His-tagged PCSK9 (unknown origin) binding to recombinant LDRR AB domain (unknown origin) at 10 uM measured after 2 hrs by ELISA | Homo sapiens | 1 | ALA4359840 | protein format | Scientific Literature | |
| 4. | ALA4361390 | B | Inhibition of recombinant His-tagged PCSK9 (unknown origin) binding to recombinant LDRR AB domain (unknown origin) at 100 uM measured after 2 hrs by ELISA relative to control | Homo sapiens | 1 | ALA4359840 | protein format | Scientific Literature | |
| 5. | ALA4361392 | B | Inhibition of PCSK9 (unknown origin) interaction with LDLR expressed in human HepG2 cells assessed as increase LDLR level on cell membrane at 10 uM measured after 2 hrs by in-cell Western analysis | Homo sapiens | 1 | ALA4359840 | cell-based format | Scientific Literature | |
| 6. | ALA4361393 | B | Inhibition of PCSK9 (unknown origin) interaction with LDLR expressed in human HepG2 cells assessed as LDLR level on cell membrane at 0.1 uM measured after 2 hrs by in-cell Western analysis (Rvb = 30.5 to 47.2%) | Homo sapiens | 1 | ALA4359840 | cell-based format | Scientific Literature | |
| 7. | ALA4361394 | B | Inhibition of PCSK9 (unknown origin) interaction with LDLR expressed in human HepG2 cells assessed as LDLR level on cell membrane at 10 uM measured after 2 hrs by in-cell Western analysis (Rvb = 30.5 to 47.2%) | Homo sapiens | 1 | ALA4359840 | cell-based format | Scientific Literature | |
| 8. | ALA4361395 | B | Inhibition of PCSK9 (unknown origin) interaction with LDLR expressed in human HepG2 cells assessed as increase LDLR level on cell membrane measured after 2 hrs by in-cell Western analysis | Homo sapiens | 1 | ALA4359840 | cell-based format | Scientific Literature | |
| 9. | ALA4361396 | B | Inhibition of PCSK9 (unknown origin) interaction with LDLR expressed in human HepG2 cells assessed as LDL uptake level at 1 uM measured after 2 hrs by LDL-Dylight 550 dye based fluorescence assay (Rvb = 34.8 to 67%) | Homo sapiens | 2 | ALA4359840 | cell-based format | Scientific Literature | |
| 10. | ALA4361397 | B | Inhibition of PCSK9 (unknown origin) interaction with LDLR expressed in human HepG2 cells assessed as increase in LDL uptake level at 10 uM measured after 2 hrs by LDL-Dylight 550 dye based fluorescence assay | Homo sapiens | 1 | ALA4359840 | cell-based format | Scientific Literature | |
| 11. | ALA4361398 | B | Inhibition of PCSK9 (unknown origin) interaction with LDLR expressed in human HepG2 cells assessed as LDL uptake level at 0.1 uM measured after 2 hrs by LDL-Dylight 550 dye based fluorescence assay (Rvb = 34.8 to 67%) | Homo sapiens | 1 | ALA4359840 | cell-based format | Scientific Literature | |
| 12. | ALA4361399 | B | Inhibition of PCSK9 (unknown origin) interaction with LDLR expressed in human HepG2 cells assessed as LDL uptake level at 10 uM measured after 2 hrs by LDL-Dylight 550 dye based fluorescence assay (Rvb = 34.8 to 67%) | Homo sapiens | 1 | ALA4359840 | cell-based format | Scientific Literature | |
| 13. | ALA4361400 | B | Inhibition of PCSK9 (unknown origin) interaction with LDLR expressed in human HepG2 cells assessed as increase in LDL uptake level measured after 24 hrs by LDL-Dylight 550 dye based fluorescence assay | Homo sapiens | 1 | ALA4359840 | cell-based format | Scientific Literature | |
| 14. | ALA4628021 | B | Inhibition of recombinant human His-tagged PCSK9 interaction with recombinant LDLR AB domain (unknown origin) measured after 3 hrs by horseradish peroxidase-coupled TMB substrate based spectrophotometry | Homo sapiens | 21 | ALA4627281 | protein format | Scientific Literature | |
| 15. | ALA4628057 | B | Inhibition of recombinant human His-tagged PCSK9 interaction with recombinant LDLR AB domain (unknown origin) at higher concentration measured after 3 hrs by horseradish peroxidase-coupled TMB substrate based spectrophotometry relative to control | Homo sapiens | 4 | ALA4627281 | protein format | Scientific Literature | |
| 16. | ALA4705210 | B | Inhibition of avi-tagged-biotinylated human PCSK9 interaction with His-tagged human LDLR EGFa domain by LANCE Ulight Streptavidin based TR-FRET assay | Homo sapiens | 59 | ALA4699634 | protein format | Scientific Literature | |
| 17. | ALA4820721 | B | Inhibition of PCSK9 (unknown origin) interaction with LDLR (unknown origin) by ELISA | Homo sapiens | 19 | ALA4819031 | protein format | Scientific Literature | |
| 18. | ALA5236416 | B | Inhibition of human PCSK9-LDLR protein-protein interaction using EGF peptide as substrate preincubated for 30 mins followed by LDLR addition and measured after 2 hrs by ELISA | Homo sapiens | 1 | ALA5233285 | protein format | Scientific Literature | |
| 19. | ALA5236420 | B | Inhibition of PCSK9-LDLR protein-protein interaction in human Huh-7 cells assessed as restoration of LDLR at 5 uM | Homo sapiens | 1 | ALA5233285 | cell-based format | Scientific Literature | |
| 20. | ALA5236421 | B | Inhibition of PCSK9-LDLR protein-protein interaction in human Huh-7 cells assessed as increase in LDL uptake at 5 uM | Homo sapiens | 1 | ALA5233285 | cell-based format | Scientific Literature |
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