# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4380722 | B | Protac activity at VHL/EGFR exon 19 deletion mutant in human HCC827 cells assessed as induction of EGFR degradation at up to 1 uM treated 8 hrs post serum starvation measured after 16 hrs by Western blot analysis | Homo sapiens | 3 | ALA4376874 | cell-based format | Scientific Literature | |
2. | ALA4380723 | B | Protac activity at VHL/EGFR exon 19 deletion mutant in human HCC827 cells assessed as induction of EGFR degradation at 10 nM treated 8 hrs post serum starvation measured after 16 hrs by Western blot analysis | Homo sapiens | 1 | ALA4376874 | cell-based format | Scientific Literature | |
3. | ALA4380727 | B | Protac activity at VHL/EGFR exon 19 deletion mutant in human HCC827 cells assessed as induction of EGFR degradation treated 8 hrs post serum starvation measured after 16 hrs by Western blot analysis | Homo sapiens | 1 | ALA4376874 | cell-based format | Scientific Literature | |
4. | ALA4380729 | B | Protac activity at VHL/EGFR L858R mutant in human H3255 cells assessed as induction of EGFR degradation treated 8 hrs post serum starvation measured after 16 hrs by Western blot analysis | Homo sapiens | 1 | ALA4376874 | cell-based format | Scientific Literature | |
5. | ALA4380731 | B | Protac activity at VHL/EGFR exon 19 deletion mutant in human HCC827 cells assessed as induction of EGFR degradation at >=50 nM treated 8 hrs post serum starvation measured after 16 hrs by Western blot analysis relative to control | Homo sapiens | 2 | ALA4376874 | cell-based format | Scientific Literature | |
6. | ALA4380733 | B | Protac activity at VHL/EGFR L858R mutant in human H3255 cells assessed as induction of EGFR degradation at >=50 nM treated 8 hrs post serum starvation measured after 16 hrs by Western blot analysis relative to control | Homo sapiens | 1 | ALA4376874 | cell-based format | Scientific Literature | |
7. | ALA4380735 | B | Protac activity at VHL/EGFR exon 19 deletion mutant in human HCC827 cells assessed as induction of EGFR degradation at 10 uM treated 8 hrs post serum starvation measured after 16 hrs by Western blot analysis | Homo sapiens | 1 | ALA4376874 | cell-based format | Scientific Literature | |
8. | ALA4380737 | B | Protac activity at VHL/EGFR L858R mutant in human H3255 cells assessed as induction of EGFR degradation at 10 uM treated 8 hrs post serum starvation measured after 16 hrs by Western blot analysis | Homo sapiens | 1 | ALA4376874 | cell-based format | Scientific Literature | |
9. | ALA4380745 | B | Protac activity at VHL/EGFR exon 19 deletion mutant in human HCC827 cells assessed as reduction in EGFR autophosphorylation up to 10 uM treated 8 hrs post serum starvation measured after 16 hrs by Western blot analysis | Homo sapiens | 2 | ALA4376874 | cell-based format | Scientific Literature | |
10. | ALA4380746 | B | Protac activity at VHL/EGFR L858R mutant in human H3255 cells assessed as reduction in EGFR autophosphorylation up to 10 uM treated 8 hrs post serum starvation measured after 16 hrs by Western blot analysis | Homo sapiens | 2 | ALA4376874 | cell-based format | Scientific Literature | |
11. | ALA4380747 | B | Protac activity at VHL/EGFR exon 19 deletion mutant in human HCC827 cells assessed as reduction in AKT phosphorylation up to 10 uM treated 8 hrs post serum starvation measured after 16 hrs by Western blot analysis | Homo sapiens | 2 | ALA4376874 | cell-based format | Scientific Literature | |
12. | ALA4380748 | B | Protac activity at VHL/EGFR L858R mutant in human H3255 cells assessed as reduction in AKT phosphorylation up to 10 uM treated 8 hrs post serum starvation measured after 16 hrs by Western blot analysis | Homo sapiens | 2 | ALA4376874 | cell-based format | Scientific Literature | |
13. | ALA4380755 | B | Protac activity at VHL/EGFR exon 19 deletion mutant in human HCC827 cells assessed as induction of EGFR degradation up to 500 nM treated 8 hrs post serum starvation measured after 16 hrs by Western blot analysis | Homo sapiens | 1 | ALA4376874 | cell-based format | Scientific Literature | |
14. | ALA4380756 | B | Protac activity at VHL/EGFR L858R mutant in human H3255 cells assessed as induction of EGFR degradation up to 500 nM treated 8 hrs post serum starvation measured after 16 hrs by Western blot analysis | Homo sapiens | 1 | ALA4376874 | cell-based format | Scientific Literature | |
15. | ALA4380757 | B | Protac activity at VHL/EGFR exon 19 deletion mutant in human HCC827 cells assessed as induction of EGFR degradation at 1 to 10 uM treated 8 hrs post serum starvation measured after 16 hrs by Western blot analysis | Homo sapiens | 1 | ALA4376874 | cell-based format | Scientific Literature | |
16. | ALA4380758 | B | Protac activity at VHL/EGFR L858R mutant in human H3255 cells assessed as induction of EGFR degradation at 1 to 10 uM treated 8 hrs post serum starvation measured after 16 hrs by Western blot analysis | Homo sapiens | 1 | ALA4376874 | cell-based format | Scientific Literature | |
17. | ALA4380767 | B | Protac activity at VHL/EGFR exon 19 deletion mutant in human HCC827 cells assessed as reduction in AKT phosphorylation at 100 nM treated 8 hrs post serum starvation measured after 4 hrs by Western blot analysis | Homo sapiens | 1 | ALA4376874 | cell-based format | Scientific Literature | |
18. | ALA4380768 | B | Protac activity at VHL/EGFR exon 19 deletion mutant in human HCC827 cells assessed as induction of EGFR degradation at 100 nM treated 8 hrs post serum starvation measured after 4 hrs by Western blot analysis relative to control | Homo sapiens | 1 | ALA4376874 | cell-based format | Scientific Literature | |
19. | ALA4380769 | B | Protac activity at VHL/EGFR exon 19 deletion mutant in human HCC827 cells assessed as induction of EGFR degradation at 100 nM treated 8 hrs post serum starvation measured after 12 to 24 hrs by Western blot analysis relative to control | Homo sapiens | 1 | ALA4376874 | cell-based format | Scientific Literature | |
20. | ALA4380772 | B | Protac activity at VHL/EGFR L858R mutant in human H3255 cells assessed as induction of EGFR degradation at 100 nM treated 8 hrs post serum starvation by Western blot analysis | Homo sapiens | 1 | ALA4376874 | cell-based format | Scientific Literature |