| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4323207 | B | Protac activity at GSPT1/CUL4/DDB1/CRBN in human RS4:11/IRMI-2 cells harboring p53 hotspot mutation Y236H/R249G assessed as decrease in GSPT1 protein level by measuring log ratio of protein level before and after treatment at 0.1 uM measured after 3 hrs relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 2. | ALA4323246 | B | Protac activity at GSPT1/CUL4/DDB1/CRBN in human RS4:11 cells expressing wild type p53 assessed as decrease in GSPT1 protein level by measuring log ratio of protein level before and after treatment at 0.1 uM measured after 3 hrs relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 3. | ALA4323247 | B | Protac activity at GSPT1/CUL4/DDB1/CRBN in human RS4:11 cells expressing wild type p53 assessed as decrease in GSPT1 protein level measured upto 24 hrs by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 4. | ALA4323248 | B | Protac activity at GSPT1/CUL4/DDB1/CRBN in human RS4:11 cells expressing wild type p53 assessed as decrease in GSPT1 protein level at 10 nM by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 5. | ALA4323249 | B | Protac activity at GSPT1/CUL4/DDB1/CRBN in human RS4:11/IRMI-2 cells harboring p53 hotspot mutation Y236H/R249G assessed as decrease in GSPT1 protein level measured upto 24 hrs by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 6. | ALA4323250 | B | Protac activity at GSPT1/CUL4/DDB1/CRBN in human RS4:11/IRMI-2 cells harboring p53 hotspot mutation Y236H/R249G assessed as decrease in GSPT1 protein level at 10 nM by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 7. | ALA4323251 | B | Protac activity at GSPT1/CUL4/DDB1/CRBN in human RS4:11 cells expressing wild type p53 assessed as effect on GSPT1 mRNA level after 3 hrs by qRT-PCR analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 8. | ALA4323252 | B | Protac activity at GSPT1/CUL4/DDB1/CRBN in human RS4:11/IRMI-2 cells harboring p53 hotspot mutation Y236H/R249G assessed as effect on GSPT1 mRNA level after 3 hrs by qRT-PCR analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 9. | ALA4323253 | B | Protac activity at GSPT1/CUL4/DDB1/CRBN in human RS4:11 cells expressing wild type p53 assessed as decrease in GSPT1 protein level at 1 to 3 uM after 24 hrs by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 10. | ALA4323254 | B | Protac activity at GSPT1/CUL4/DDB1/CRBN in human RS4:11/IRMI-2 cells harboring p53 hotspot mutation Y236H/R249G assessed as decrease in GSPT1 protein level at 1 to 3 uM after 24 hrs by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 11. | ALA4323255 | B | Protac activity at GSPT1/CUL4/DDB1/CRBN in human RS4:11 cells expressing wild type p53 assessed as decrease in GSPT1 protein level after 2 hrs by Western blot analysis | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
| 12. | ALA4323256 | B | Protac activity at GSPT1/CUL4/DDB1/CRBN in human RS4:11/IRMI-2 cells harboring p53 hotspot mutation Y236H/R249G assessed as decrease in GSPT1 protein level after 2 hrs by Western blot analysis | Homo sapiens | 6 | cell-based format | Scientific Literature |
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