# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4323207 | Binding | Protac activity at GSPT1/CUL4/DDB1/CRBN in human RS4:11/IRMI-2 cells harboring p53 hotspot mutation Y236H/R249G assessed as decrease in GSPT1 protein level by measuring log ratio of protein level before and after treatment at 0.1 uM measured after 3 hrs relative to control | Homo sapiens | 1 | ALA4321819 | cell-based format | Scientific Literature | |
2. | ALA4323246 | Binding | Protac activity at GSPT1/CUL4/DDB1/CRBN in human RS4:11 cells expressing wild type p53 assessed as decrease in GSPT1 protein level by measuring log ratio of protein level before and after treatment at 0.1 uM measured after 3 hrs relative to control | Homo sapiens | 1 | ALA4321819 | cell-based format | Scientific Literature | |
3. | ALA4323247 | Binding | Protac activity at GSPT1/CUL4/DDB1/CRBN in human RS4:11 cells expressing wild type p53 assessed as decrease in GSPT1 protein level measured upto 24 hrs by Western blot analysis | Homo sapiens | 2 | ALA4321819 | cell-based format | Scientific Literature | |
4. | ALA4323248 | Binding | Protac activity at GSPT1/CUL4/DDB1/CRBN in human RS4:11 cells expressing wild type p53 assessed as decrease in GSPT1 protein level at 10 nM by Western blot analysis | Homo sapiens | 2 | ALA4321819 | cell-based format | Scientific Literature | |
5. | ALA4323249 | Binding | Protac activity at GSPT1/CUL4/DDB1/CRBN in human RS4:11/IRMI-2 cells harboring p53 hotspot mutation Y236H/R249G assessed as decrease in GSPT1 protein level measured upto 24 hrs by Western blot analysis | Homo sapiens | 2 | ALA4321819 | cell-based format | Scientific Literature | |
6. | ALA4323250 | Binding | Protac activity at GSPT1/CUL4/DDB1/CRBN in human RS4:11/IRMI-2 cells harboring p53 hotspot mutation Y236H/R249G assessed as decrease in GSPT1 protein level at 10 nM by Western blot analysis | Homo sapiens | 2 | ALA4321819 | cell-based format | Scientific Literature | |
7. | ALA4323251 | Binding | Protac activity at GSPT1/CUL4/DDB1/CRBN in human RS4:11 cells expressing wild type p53 assessed as effect on GSPT1 mRNA level after 3 hrs by qRT-PCR analysis | Homo sapiens | 1 | ALA4321819 | cell-based format | Scientific Literature | |
8. | ALA4323252 | Binding | Protac activity at GSPT1/CUL4/DDB1/CRBN in human RS4:11/IRMI-2 cells harboring p53 hotspot mutation Y236H/R249G assessed as effect on GSPT1 mRNA level after 3 hrs by qRT-PCR analysis | Homo sapiens | 1 | ALA4321819 | cell-based format | Scientific Literature | |
9. | ALA4323253 | Binding | Protac activity at GSPT1/CUL4/DDB1/CRBN in human RS4:11 cells expressing wild type p53 assessed as decrease in GSPT1 protein level at 1 to 3 uM after 24 hrs by Western blot analysis | Homo sapiens | 2 | ALA4321819 | cell-based format | Scientific Literature | |
10. | ALA4323254 | Binding | Protac activity at GSPT1/CUL4/DDB1/CRBN in human RS4:11/IRMI-2 cells harboring p53 hotspot mutation Y236H/R249G assessed as decrease in GSPT1 protein level at 1 to 3 uM after 24 hrs by Western blot analysis | Homo sapiens | 2 | ALA4321819 | cell-based format | Scientific Literature | |
11. | ALA4323255 | Binding | Protac activity at GSPT1/CUL4/DDB1/CRBN in human RS4:11 cells expressing wild type p53 assessed as decrease in GSPT1 protein level after 2 hrs by Western blot analysis | Homo sapiens | 6 | ALA4321819 | cell-based format | Scientific Literature | |
12. | ALA4323256 | Binding | Protac activity at GSPT1/CUL4/DDB1/CRBN in human RS4:11/IRMI-2 cells harboring p53 hotspot mutation Y236H/R249G assessed as decrease in GSPT1 protein level after 2 hrs by Western blot analysis | Homo sapiens | 6 | ALA4321819 | cell-based format | Scientific Literature |