| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA2049385 | F | Induction of morphological changes in human SBcl2 cells assessed as less density and round shape phenotype with fewer dendrites of cells at IC50 after 24 to 48 hrs | Homo sapiens | 1 | ALA2046340 | cell-based format | Scientific Literature | |
| 2. | ALA2049395 | F | Induction of apoptosis in human SBcl2 cells assessed as less accumulation at sub-G1 phase at IC50 after 24 by caspase-glo 3/7 assay | Homo sapiens | 1 | ALA2046340 | cell-based format | Scientific Literature | |
| 3. | ALA3992040 | F | Antitumor activity against human SBcl2 cells xenografted in ip dosed athymic nude mouse assessed as reduction in tumor growth administered as qd for 5 days | Homo sapiens | 1 | ALA3991943 | organism-based format | Patent Bioactivity Data | |
| 4. | ALA4604343 | F | Cytotoxicity against human SBcl2 cells harboring NRAS Q61I mutant assessed as reduction in cell viability after 24 hrs by EZ4U reagent based spectrophotometric method | Homo sapiens | 1 | ALA4602659 | cell-based format | Scientific Literature | |
| 5. | ALA4604344 | F | Cytotoxicity against human SBcl2 cells harboring NRAS Q61I mutant assessed as reduction in cell viability after 48 hrs by EZ4U reagent based spectrophotometric method | Homo sapiens | 1 | ALA4602659 | cell-based format | Scientific Literature | |
| 6. | ALA4604345 | F | Cytotoxicity against human SBcl2 cells harboring NRAS Q61I mutant assessed as reduction in cell viability after 72 hrs by EZ4U reagent based spectrophotometric method | Homo sapiens | 1 | ALA4602659 | cell-based format | Scientific Literature | |
| 7. | ALA4604363 | F | Induction of apoptosis in human SBcl2 cells assessed as viable cells at IC50 concentration after 6 hrs by Annexin V/SYTOX Green based flow cytometric analysis (Rvb = 80.68%) | Homo sapiens | 1 | ALA4602659 | cell-based format | Scientific Literature | |
| 8. | ALA4604364 | F | Induction of apoptosis in human SBcl2 cells assessed as early apoptotic cells at IC50 concentration after 6 hrs by Annexin V/SYTOX Green based flow cytometric analysis (Rvb = 4.26%) | Homo sapiens | 1 | ALA4602659 | cell-based format | Scientific Literature | |
| 9. | ALA4604365 | F | Induction of apoptosis in human SBcl2 cells assessed as late apoptotic cells at IC50 concentration after 6 hrs by Annexin V/SYTOX Green based flow cytometric analysis (Rvb = 14.91%) | Homo sapiens | 1 | ALA4602659 | cell-based format | Scientific Literature | |
| 10. | ALA4604366 | F | Induction of apoptosis in human SBcl2 cells assessed as necrotic cells at IC50 concentration after 6 hrs by Annexin V/SYTOX Green based flow cytometric analysis (Rvb = 0.17%) | Homo sapiens | 1 | ALA4602659 | cell-based format | Scientific Literature | |
| 11. | ALA4604383 | F | Induction of apoptosis in human SBcl2 cells assessed as viable cells at IC50 concentration after 24 hrs by Annexin V/SYTOX Green based flow cytometric analysis (Rvb = 73.08%) | Homo sapiens | 1 | ALA4602659 | cell-based format | Scientific Literature | |
| 12. | ALA4604384 | F | Induction of apoptosis in human SBcl2 cells assessed as early apoptotic cells at IC50 concentration after 6 hrs by Annexin V/SYTOX Green based flow cytometric analysis (Rvb = 3.77%) | Homo sapiens | 1 | ALA4602659 | cell-based format | Scientific Literature | |
| 13. | ALA4604385 | F | Induction of apoptosis in human SBcl2 cells assessed as late apoptotic cells at IC50 concentration after 24 hrs by Annexin V/SYTOX Green based flow cytometric analysis (Rvb = 22.96%) | Homo sapiens | 1 | ALA4602659 | cell-based format | Scientific Literature | |
| 14. | ALA4604386 | F | Induction of apoptosis in human SBcl2 cells assessed as necrotic cells at IC50 concentration after 24 hrs by Annexin V/SYTOX Green based flow cytometric analysis (Rvb = 0.21%) | Homo sapiens | 1 | ALA4602659 | cell-based format | Scientific Literature | |
| 15. | ALA4604397 | F | Cytotoxicity against human SBcl2 cells harboring NRAS Q61I mutant assessed as reduction in cell viability by EZ4U reagent based spectrophotometric method | Homo sapiens | 1 | ALA4602659 | cell-based format | Scientific Literature | |
| 16. | ALA4604406 | F | Induction of apoptosis in human SBcl2 cells assessed as increase in caspase -3 activity at IC50 concentration after 24 hrs by Alexa Fluor 647 antibody based flow cytometric analysis | Homo sapiens | 1 | ALA4602659 | cell-based format | Scientific Literature | |
| 17. | ALA4604411 | F | Induction of apoptosis in human SBcl2 cells assessed as up regulation of PMAIP1 at IC50 concentration after 24 hrs by mRNA sequencing method relative to control | Homo sapiens | 1 | ALA4602659 | cell-based format | Scientific Literature | |
| 18. | ALA4604414 | F | Antitumour activity against human SBcl2 cells xenografted in NU(NCr)-Foxn1 mouse assessed as increase in necrotic cells at 2 ug/g administered for three consecutive days with 1 day interval for four cycle by hematoxylin and eosin staining based microscopic analysis | Homo sapiens | 1 | ALA4602659 | cell-based format | Scientific Literature | |
| 19. | ALA4604416 | F | Antitumour activity against human SBcl2 cells xenografted in NU(NCr)-Foxn1 mouse assessed as increase in caspase -activity at 2 ug/g administered for three consecutive days with 1 day interval for four cycle by hematoxylin and eosin staining based microscopic analysis | Homo sapiens | 1 | ALA4602659 | cell-based format | Scientific Literature | |
| 20. | ALA4604418 | F | Antitumour activity against human SBcl2 cells xenografted in NU(NCr)-Foxn1 mouse assessed as increase in fibrosis at 2 ug/g administered for three consecutive days with 1 day interval for four cycle by hematoxylin and eosin staining based microscopic analysis | Homo sapiens | 1 | ALA4602659 | cell-based format | Scientific Literature |
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