| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4619613 | A | Protac activity at Cereblon/Flt3 in human K562 cells assessed as reduction in Flt3 protein levels at 3 to 30000 nM incubated for 48 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 2. | ALA5107689 | B | PROTAC activity at CRBN/FLT3-ITD mutant in human MOLM-14 cells assessed as decrease in FLT3 protein expression at 0.03 to 3 uM incubated for 24 hrs by Western blot analysis | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 3. | ALA5107690 | B | PROTAC activity at CRBN/FLT3-ITD mutant in human MV4-11 cells assessed as decrease in FLT3 protein expression at 0.03 to 3 uM incubated for 24 hrs by Western blot analysis | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 4. | ALA5107692 | B | PROTAC activity at CRBN/FLT3-ITD mutant in human MV4-11 cells assessed as decrease in AXL protein expression at 0.03 to 3 uM incubated for 24 hrs by Western blot analysis | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 5. | ALA5107694 | B | PROTAC activity at CRBN/FLT3-ITD mutant in human MV4-11 cells assessed as inhibition of FLT3 phosphorylation at 0.03 to 3 uM incubated for 24 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 6. | ALA5107695 | B | PROTAC activity at CRBN/FLT3-ITD mutant in human MV4-11 cells assessed as inhibition of STAT5 phosphorylation at 0.03 to 3 uM incubated for 24 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 7. | ALA5107698 | B | PROTAC activity at CRBN/FLT3-ITD mutant in human MOLM-14 cells assessed as decrease in FLT3 mRNA expression at 0.03 to 3 uM incubated for 24 hrs by RT-qPCR analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 8. | ALA5107699 | B | PROTAC activity at CRBN/FLT3-ITD mutant in human MV4-11 cells at 30 nM measured upto 32 hrs in the presence of cycloheximide by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 9. | ALA5107701 | B | PROTAC activity at CRBN/FLT3-ITD mutant in human MV4-11 cells assessed as decrease in FLT3 protein expression at 0.03 uM incubated for 18 hrs in the presence of carfilzomib by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 10. | ALA5107702 | B | PROTAC activity at CRBN/FLT3-ITD mutant in human MV4-11 cells assessed as decrease in FLT3 protein expression at 0.03 uM incubated for 18 hrs in the presence of MLN7243 by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 11. | ALA5107703 | B | PROTAC activity at CRBN/FLT3-ITD mutant in human MV4-11 cells assessed as decrease in FLT3 protein expression at 0.3 to 3 uM incubated for 18 hrs in the presence of bafilomycin A1 by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 12. | ALA5107704 | B | PROTAC activity at CRBN/FLT3-ITD mutant in human MV4-11 cells assessed as decrease in FLT3 protein expression at 3 to 100 nM incubated for 18 hrs in the presence of MLN4924 by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 13. | ALA5107710 | B | PROTAC activity at CRBN/FLT3-ITD mutant in human MOLM-14 cells assessed as decrease in IKZF1 protein expression at 0.01 to 0.3 uM incubated for 24 hrs by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 14. | ALA5107711 | B | PROTAC activity at CRBN/FLT3-ITD mutant in human MV4-11 cells assessed as decrease in IKZF1 protein expression at 0.01 to 0.3 uM incubated for 24 hrs by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 15. | ALA5107712 | B | PROTAC activity at CRBN/FLT3-ITD mutant in human MV4-11 cells assessed as decrease in LTK protein expression by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 16. | ALA5107713 | B | PROTAC activity at CRBN/FLT3-ITD mutant in human MV4-11 cells assessed as decrease in ALK protein expression by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 17. | ALA5107714 | B | PROTAC activity at CRBN/FLT3-ITD mutant in human MOLM-14 cells assessed as decrease in LTK protein expression by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 18. | ALA5107715 | B | PROTAC activity at CRBN/FLT3-ITD mutant in human MOLM-14 cells assessed as decrease in ALK protein expression by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature |
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