# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4605875 | Binding | Protac activity at VHL/HDAC6 in human MM1S cells assessed as HDAC6 degradation at 100 nM measured after 6 hrs by ELISA | Homo sapiens | 11 | ALA4602716 | cell-based format | Scientific Literature | |
2. | ALA4605876 | Binding | Protac activity at VHL/HDAC6 in human MM1S cells assessed as HDAC6 degradation at 100 nM measured after 6 hrs by Western blot analysis | Homo sapiens | 5 | ALA4602716 | cell-based format | Scientific Literature | |
3. | ALA4605877 | Binding | Protac activity at VHL/HDAC6 in human MM1S cells assessed as increase in tubulin acetylation at 100 nM measured after 6 hrs by Western blot analysis | Homo sapiens | 3 | ALA4602716 | cell-based format | Scientific Literature | |
4. | ALA4605879 | Binding | Protac activity at VHL/HDAC6 in human MM1S cells measured after 6 hrs by ELISA | Homo sapiens | 2 | ALA4602716 | cell-based format | Scientific Literature | |
5. | ALA4605881 | Binding | Protac activity at VHL/HDAC6 in human MM1S cells measured after 6 hrs by ELISA relative to control | Homo sapiens | 2 | ALA4602716 | cell-based format | Scientific Literature | |
6. | ALA4605882 | Binding | Protac activity at VHL/HDAC6 in human MM1S cells assessed as HDAC6 degradation at 10 nM measured after 4 hrs by Western blot analysis | Homo sapiens | 1 | ALA4602716 | cell-based format | Scientific Literature | |
7. | ALA4605883 | Binding | Protac activity at VHL/HDAC6 in human MM1S cells assessed as HDAC6 degradation at 100 nM measured after 4 hrs by Western blot analysis | Homo sapiens | 1 | ALA4602716 | cell-based format | Scientific Literature | |
8. | ALA4605884 | Binding | Protac activity at VHL/HDAC6 in human MM1S cells assessed as compound-VHL complex formation at 3 uM after 6 hrs | Homo sapiens | 1 | ALA4602716 | cell-based format | Scientific Literature | |
9. | ALA4605885 | Binding | Protac activity at VHL/HDAC6 in human MM1S cells assessed as compound-HDAC6 complex formation at 3 uM after 6 hrs | Homo sapiens | 1 | ALA4602716 | cell-based format | Scientific Literature | |
10. | ALA4605886 | Binding | Protac activity at VHL/HDAC6 in human MM1S cells assessed as induction of tubulin acetylation after 4 hrs by Western blot analysis | Homo sapiens | 1 | ALA4602716 | cell-based format | Scientific Literature | |
11. | ALA4605887 | Binding | Protac activity at VHL/HDAC6 in human MM1S cells assessed as induction of tubulin acetylation at 1 uM after 4 hrs by Western blot analysis | Homo sapiens | 1 | ALA4602716 | cell-based format | Scientific Literature | |
12. | ALA4605888 | Binding | Protac activity at VHL/HDAC6 in human MM1S cells assessed as increase in tubulin acetylation at 300 nM after 4 hrs by Western blot analysis | Homo sapiens | 1 | ALA4602716 | cell-based format | Scientific Literature | |
13. | ALA4605898 | Binding | Protac activity at VHL/HDAC6 in human MM1S cells assessed as tubulin acetylation at 100 nM to 1 microM after 6 hrs by Western blot analysis | Homo sapiens | 1 | ALA4602716 | cell-based format | Scientific Literature | |
14. | ALA4605899 | Binding | Protac activity at VHL/HDAC6 in human MM1S cells assessed as reduction in protein level at 100 nM after 30 mins by Western blot analysis | Homo sapiens | 1 | ALA4602716 | cell-based format | Scientific Literature | |
15. | ALA4605901 | Binding | Protac activity at VHL/HDAC6 in human MM1S cells assessed as reduction in protein level at 100 nM after 4 hrs by Western blot analysis | Homo sapiens | 1 | ALA4602716 | cell-based format | Scientific Literature | |
16. | ALA4605903 | Binding | Protac activity at VHL/HDAC6 in human MM1S cells assessed as HDAC6 degradation at 100 nM pretreated for 1 hr in presence of proteasome inhibitor MG132 by Western blot analysis | Homo sapiens | 1 | ALA4602716 | cell-based format | Scientific Literature | |
17. | ALA4605904 | Binding | Protac activity at VHL/HDAC6 in human MM1S cells assessed as HDAC6 degradation at 100 nM pretreated for 1 hr in presence of proteasome inhibitor Bortezomib by Western blot analysis | Homo sapiens | 1 | ALA4602716 | cell-based format | Scientific Literature | |
18. | ALA4605905 | Binding | Protac activity at VHL/HDAC6 in human MM1S cells assessed as HDAC6 degradation at 100 nM pretreated for 1 hr in presence of HDAC6 inhibitor Next-A by Western blot analysis | Homo sapiens | 1 | ALA4602716 | cell-based format | Scientific Literature | |
19. | ALA4605906 | Binding | Protac activity at VHL/HDAC6 in human MM1S cells assessed as HDAC6 degradation at 100 nM pretreated for 1 hr in presence of 5 uM VHL-1 by Western blot analysis | Homo sapiens | 1 | ALA4602716 | cell-based format | Scientific Literature | |
20. | ALA4605907 | Binding | Protac activity at VHL/HDAC6 in human HEK293T cells assessed as induction of HDAC degradation by Western blot analysis | Homo sapiens | 1 | ALA4602716 | cell-based format | Scientific Literature |