# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4618213 | B | Protac activity at VHL1/SHP2 in human KYSE520 cells assessed as induction of SHP2 degradation at 0.1 uM measured after 6 hrs by Western blot analysis relative to control | Homo sapiens | 23 | ALA4616666 | cell-based format | Scientific Literature | |
2. | ALA4618215 | B | Protac activity at VHL1/SHP2 in human KYSE520 cells assessed as induction of SHP2 degradation at 1 uM measured after 6 hrs by Western blot analysis relative to control | Homo sapiens | 23 | ALA4616666 | cell-based format | Scientific Literature | |
3. | ALA4618216 | B | Protac activity at VHL1/SHP2 in human MV4-11 cells assessed as induction of SHP2 degradation at 0.1 uM measured after 24 hrs by Western blot analysis relative to control | Homo sapiens | 10 | ALA4616666 | cell-based format | Scientific Literature | |
4. | ALA4618218 | B | Protac activity at VHL1/SHP2 in human KYSE520 cells assessed as induction of SHP2 degradation measured after 12 hrs by Western blot analysis | Homo sapiens | 1 | ALA4616666 | cell-based format | Scientific Literature | |
5. | ALA4618219 | B | Protac activity at VHL1/SHP2 in human MV4-11 cells assessed as induction of SHP2 degradation measured after 12 hrs by Western blot analysis | Homo sapiens | 1 | ALA4616666 | cell-based format | Scientific Literature | |
6. | ALA4618220 | B | Protac activity at VHL1/SHP2 in human KYSE520 cells assessed as induction of SHP2 degradation at 100 nM measured within 4 hrs by Western blot analysis | Homo sapiens | 1 | ALA4616666 | cell-based format | Scientific Literature | |
7. | ALA4618221 | B | Protac activity at VHL1/SHP2 in human KYSE520 cells assessed as induction of SHP2 degradation at 100 nM measured after 8 hrs by Western blot analysis relative to control | Homo sapiens | 1 | ALA4616666 | cell-based format | Scientific Literature | |
8. | ALA4618222 | B | Protac activity at VHL1/SHP2 in human MV4-11 cells assessed as induction of SHP2 degradation at 100 nM measured after 4 to 8 hrs by Western blot analysis | Homo sapiens | 1 | ALA4616666 | cell-based format | Scientific Literature | |
9. | ALA4618223 | B | Protac activity at VHL1/SHP2 in human KYSE520 cells assessed as induction of SHP2 degradation at 0.1 uM measured after 3 hrs in presence of VHL-1 ligand by Western blot analysis | Homo sapiens | 1 | ALA4616666 | cell-based format | Scientific Literature | |
10. | ALA4618224 | B | Protac activity at VHL1/SHP2 in human KYSE520 cells assessed as induction of SHP2 degradation at 0.1 uM measured after 3 hrs in presence of SHP2 inhibitor by Western blot analysis | Homo sapiens | 1 | ALA4616666 | cell-based format | Scientific Literature | |
11. | ALA4618225 | B | Protac activity at VHL1/SHP2 in human KYSE520 cells assessed as induction of SHP2 degradation at 0.1 uM measured after 3 hrs in presence of E1 inhibitor MLN4924 by Western blot analysis | Homo sapiens | 1 | ALA4616666 | cell-based format | Scientific Literature | |
12. | ALA4618226 | B | Protac activity at VHL1/SHP2 in human KYSE520 cells assessed as induction of SHP2 degradation at 0.1 uM measured after 3 hrs in presence of proteasome inhibitor MG132 by Western blot analysis | Homo sapiens | 1 | ALA4616666 | cell-based format | Scientific Literature | |
13. | ALA4618227 | B | Protac activity at VHL1/SHP2 in human KYSE520 cells assessed as reduction in ERK phosphorylation measured after 48 hrs by Western blot analysis | Homo sapiens | 1 | ALA4616666 | cell-based format | Scientific Literature | |
14. | ALA4618228 | B | Protac activity at VHL1/SHP2 in human MV4-11 cells assessed as reduction in ERK phosphorylation measured after 48 hrs by Western blot analysis | Homo sapiens | 1 | ALA4616666 | cell-based format | Scientific Literature | |
15. | ALA4618231 | B | Protac activity at VHL1/SHP2 in human KYSE520 cells assessed as reduction in ERK phosphorylation at 100 nM measured after 48 hrs by Western blot analysis | Homo sapiens | 1 | ALA4616666 | cell-based format | Scientific Literature | |
16. | ALA4618233 | B | Protac activity at VHL1/SHP2 in human MV4-11 cells assessed as reduction in ERK phosphorylation at 100 nM measured after 48 hrs by Western blot analysis relative to control | Homo sapiens | 1 | ALA4616666 | cell-based format | Scientific Literature |