# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4605890 | Binding | Protac activity at VHL/HDAC2 in human MM1S cells assessed as HDAC2 degradation at 100 nM after 4 hrs by Western blot analysis | Homo sapiens | 1 | ALA4602716 | cell-based format | Scientific Literature | |
2. | ALA5045981 | Binding | Protac activity at VHL/HDAC2 in human HCT-116 cells assessed as reduction in LSD1 level measured after 48 hrs by Western blot analysis | Homo sapiens | 3 | ALA5042553 | cell-based format | Scientific Literature | |
3. | ALA5045982 | Binding | Protac activity at VHL/HDAC2 in human HCT-116 cells assessed as reduction in LSD1 level measured after 24 hrs by Western blot analysis | Homo sapiens | 1 | ALA5042553 | cell-based format | Scientific Literature | |
4. | ALA5045983 | Binding | Protac activity at VHL/HDAC2 in human HCT-116 cells assessed as induction of HDAC2 degradation incubated for 24 hrs by Western blot analysis | Homo sapiens | 1 | ALA5042553 | cell-based format | Scientific Literature | |
5. | ALA5045985 | Binding | Protac activity at VHL/HDAC2 in human HCT-116 cells assessed as induction of HDAC2 degradation at 10 uM incubated for 24 hrs by Western blot analysis | Homo sapiens | 6 | ALA5042553 | cell-based format | Scientific Literature | |
6. | ALA5045988 | Binding | Protac activity at VHL/HDAC2 in human HCT-116 cells assessed as induction of HDAC2 degradation at 1 to 10 uM incubated for 24 hrs by Western blot analysis | Homo sapiens | 11 | ALA5042553 | cell-based format | Scientific Literature | |
7. | ALA5045994 | Binding | Protac activity at VHL/HDAC2 in human HCT-116 cells assessed as induction of HDAC2 degradation at 1 uM incubated for 24 hrs by Western blot analysis relative to control | Homo sapiens | 4 | ALA5042553 | cell-based format | Scientific Literature | |
8. | ALA5046001 | Binding | Protac activity at VHL/HDAC2 in human HCT-116 cells assessed as increase in H3K56ac levels at 10 uM incubated for 24 hrs by Western blot analysis | Homo sapiens | 20 | ALA5042553 | cell-based format | Scientific Literature | |
9. | ALA5046005 | Binding | Protac activity at VHL/HDAC2 in human HCT-116 cells assessed as induction of HDAC2 degradation at 1 uM measured upto 48 hrs by Western blot analysis | Homo sapiens | 1 | ALA5042553 | cell-based format | Scientific Literature | |
10. | ALA5046008 | Binding | Protac activity at VHL/HDAC2 in human HCT-116 cells assessed as induction of HDAC2 degradation at 10 uM measured after 4 hrs by Western blot analysis | Homo sapiens | 1 | ALA5042553 | cell-based format | Scientific Literature | |
11. | ALA5046010 | Binding | Protac activity at VHL/HDAC2 in human HCT-116 cells assessed as induction of HDAC2 degradation at 10 uM measured upto 48 hrs by Western blot analysis relative to control | Homo sapiens | 1 | ALA5042553 | cell-based format | Scientific Literature | |
12. | ALA5046011 | Binding | Protac activity at VHL/HDAC2 in human HCT-116 cells assessed as fold increase in H3K56ac at 10 uM measured after 8 hrs by Western blot analysis relative to control | Homo sapiens | 1 | ALA5042553 | cell-based format | Scientific Literature | |
13. | ALA5046018 | Binding | Protac activity at VHL/HDAC2 in human HCT-116 cells assessed as reduction in SIN3A level at 10 uM measured after 24 hrs by Western blot analysis | Homo sapiens | 2 | ALA5042553 | cell-based format | Scientific Literature | |
14. | ALA5046030 | Binding | Protac activity at VHL/HDAC2 in human HCT-116 cells assessed as reduction in SIN3A level at 10 uM measured after 48 hrs by Western blot analysis | Homo sapiens | 3 | ALA5042553 | cell-based format | Scientific Literature | |
15. | ALA5107735 | Binding | PROTAC activity at VHL/HDAC2 in human HCT-116 cells assessed as induction of HDAC2 degradation at 10 uM incubated for 24 hrs by Western blot analysis relative to control | Homo sapiens | 2 | ALA5104222 | cell-based format | Scientific Literature | |
16. | ALA5107737 | Binding | PROTAC activity at VHL/HDAC2 in human HCT-116 cells assessed as induction of HDAC2 degradation at 0.1 to 10 uM incubated for 24 hrs by Western blot analysis relative to control | Homo sapiens | 2 | ALA5104222 | cell-based format | Scientific Literature | |
17. | ALA5107743 | Binding | PROTAC activity at VHL/HDAC2 in human HCT-116 cells assessed as induction of HDAC1 degradation incubated for 24 hrs by Western blot analysis | Homo sapiens | 3 | ALA5104222 | cell-based format | Scientific Literature | |
18. | ALA5107750 | Binding | PROTAC activity at VHL/HDAC2 in human HCT-116 cells assessed as induction of HDAC2 degradation by measuring maximum efficacy at 10 uM incubated for 24 hrs by Western blot analysis relative to control | Homo sapiens | 3 | ALA5104222 | cell-based format | Scientific Literature | |
19. | ALA5107762 | Binding | PROTAC activity at VHL/HDAC2 in human HCT-116 cells assessed as HDAC2 level at 0.01 uM incubated for 24 hrs by Western blot analysis relative to control | Homo sapiens | 1 | ALA5104222 | cell-based format | Scientific Literature | |
20. | ALA5107763 | Binding | PROTAC activity at VHL/HDAC2 in human HCT-116 cells assessed as HDAC2 level at 0.025 uM incubated for 24 hrs by Western blot analysis relative to control | Homo sapiens | 1 | ALA5104222 | cell-based format | Scientific Literature |