# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4605889 | Binding | Protac activity at VHL/HDAC1 in human MM1S cells assessed as HDAC1 degradation at 100 nM after 4 hrs by Western blot analysis | Homo sapiens | 1 | ALA4602716 | cell-based format | Scientific Literature | |
2. | ALA5045984 | Binding | Protac activity at VHL/HDAC1 in human HCT-116 cells assessed as induction of HDAC1 degradation at 10 uM incubated for 24 hrs by Western blot analysis | Homo sapiens | 5 | ALA5042553 | cell-based format | Scientific Literature | |
3. | ALA5045987 | Binding | Protac activity at VHL/HDAC1 in human HCT-116 cells assessed as induction of HDAC1 degradation at 1 to 10 uM incubated for 24 hrs by Western blot analysis | Homo sapiens | 13 | ALA5042553 | cell-based format | Scientific Literature | |
4. | ALA5045990 | Binding | Protac activity at VHL/HDAC1 in human HCT-116 cells assessed as induction of HDAC1 degradation at 1 uM incubated for 24 hrs by Western blot analysis | Homo sapiens | 3 | ALA5042553 | cell-based format | Scientific Literature | |
5. | ALA5045993 | Binding | Protac activity at VHL/HDAC1 in human HCT-116 cells assessed as induction of HDAC1 degradation at 1 uM incubated for 24 hrs by Western blot analysis relative to control | Homo sapiens | 4 | ALA5042553 | cell-based format | Scientific Literature | |
6. | ALA5045996 | Binding | Protac activity at VHL/HDAC1 in human HCT-116 cells assessed as induction of HDAC1 degradation incubated for 24 hrs by Western blot analysis | Homo sapiens | 4 | ALA5042553 | cell-based format | Scientific Literature | |
7. | ALA5046000 | Binding | Protac activity at VHL/HDAC1 in human HCT-116 cells assessed as increase in H3K56ac levels at 10 uM incubated for 24 hrs by Western blot analysis | Homo sapiens | 21 | ALA5042553 | cell-based format | Scientific Literature | |
8. | ALA5046003 | Binding | Protac activity at VHL/HDAC1 in human HCT-116 cells assessed as fold increase in H3K56ac at 10 uM measured after 8 hrs by Western blot analysis relative to control | Homo sapiens | 1 | ALA5042553 | cell-based format | Scientific Literature | |
9. | ALA5046004 | Binding | Protac activity at VHL/HDAC1 in human HCT-116 cells assessed as induction of HDAC1 degradation at 10 uM measured after 4 hrs by Western blot analysis | Homo sapiens | 1 | ALA5042553 | cell-based format | Scientific Literature | |
10. | ALA5046006 | Binding | Protac activity at VHL/HDAC1 in human HCT-116 cells assessed as induction of HDAC1 degradation at 1 uM measured upto 48 hrs by Western blot analysis | Homo sapiens | 1 | ALA5042553 | cell-based format | Scientific Literature | |
11. | ALA5046009 | Binding | Protac activity at VHL/HDAC1 in human HCT-116 cells assessed as induction of HDAC1 degradation at 10 uM measured upto 48 hrs by Western blot analysis relative to control | Homo sapiens | 1 | ALA5042553 | cell-based format | Scientific Literature | |
12. | ALA5046015 | Binding | Protac activity at VHL/HDAC1 in human HCT-116 cells assessed as reduction in LSD1 level measured after 24 hrs by Western blot analysis | Homo sapiens | 1 | ALA5042553 | cell-based format | Scientific Literature | |
13. | ALA5046016 | Binding | Protac activity at VHL/HDAC1 in human HCT-116 cells assessed as reduction in LSD1 level measured after 48 hrs by Western blot analysis | Homo sapiens | 3 | ALA5042553 | cell-based format | Scientific Literature | |
14. | ALA5046017 | Binding | Protac activity at VHL/HDAC1 in human HCT-116 cells assessed as reduction in SIN3A level at 10 uM measured after 24 hrs by Western blot analysis | Homo sapiens | 2 | ALA5042553 | cell-based format | Scientific Literature | |
15. | ALA5046029 | Binding | Protac activity at VHL/HDAC1 in human HCT-116 cells assessed as reduction in SIN3A level at 10 uM measured after 48 hrs by Western blot analysis | Homo sapiens | 3 | ALA5042553 | cell-based format | Scientific Literature | |
16. | ALA5107734 | Binding | PROTAC activity at VHL/HDAC1 in human HCT-116 cells assessed as induction of HDAC1 degradation at 10 uM incubated for 24 hrs by Western blot analysis relative to control | Homo sapiens | 1 | ALA5104222 | cell-based format | Scientific Literature | |
17. | ALA5107736 | Binding | PROTAC activity at VHL/HDAC1 in human HCT-116 cells assessed as induction of HDAC1 degradation at 0.1 to 10 uM incubated for 24 hrs by Western blot analysis relative to control | Homo sapiens | 2 | ALA5104222 | cell-based format | Scientific Literature | |
18. | ALA5107742 | Binding | PROTAC activity at VHL/HDAC1 in human HCT-116 cells assessed as induction of HDAC1 degradation incubated for 24 hrs by Western blot analysis | Homo sapiens | 3 | ALA5104222 | cell-based format | Scientific Literature | |
19. | ALA5107749 | Binding | PROTAC activity at VHL/HDAC1 in human HCT-116 cells assessed as induction of HDAC1 degradation by measuring maximum efficacy at 10 uM incubated for 24 hrs by Western blot analysis relative to control | Homo sapiens | 3 | ALA5104222 | cell-based format | Scientific Literature | |
20. | ALA5107752 | Binding | PROTAC activity at VHL/HDAC1 in human HCT-116 cells assessed as HDAC1 level at 2.5 uM incubated for 24 hrs by Western blot analysis relative to control | Homo sapiens | 1 | ALA5104222 | cell-based format | Scientific Literature |