| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4603690 | B | Agonist activity at TLR7/8 in dog PBMC assessed as TNFalpha secretion at 20 uM after 29 hrs by ELISA (Rvb = 8 +/- 2 pg/ml) | Canis lupus familiaris | 13 | cell-based format | Scientific Literature | ||
| 2. | ALA4603691 | B | Agonist activity at TLR7/8 in dog PBMC assessed as IL-12 secretion at 20 uM after 29 hrs by ELISA (Rvb = 18 +/- 8 pg/ml) | Canis lupus familiaris | 13 | cell-based format | Scientific Literature | ||
| 3. | ALA4603692 | B | Agonist activity at TLR7/8 in dog PBMC assessed as IL-6 secretion at 20 uM after 29 hrs by ELISA (Rvb = 310 +/- 90 pg/ml) | Canis lupus familiaris | 13 | cell-based format | Scientific Literature | ||
| 4. | ALA4603693 | B | Agonist activity at TLR7/8 in dog PBMC assessed as IL-10 secretion at 20 uM after 29 hrs by ELISA (Rvb = 33 +/- 16 pg/ml) | Canis lupus familiaris | 13 | cell-based format | Scientific Literature | ||
| 5. | ALA4603694 | B | Agonist activity at TLR7/8 in dog PBMC assessed as IL-2 secretion at 20 uM after 29 hrs by ELISA (Rvb = 47 +/- 20 pg/ml) | Canis lupus familiaris | 13 | cell-based format | Scientific Literature | ||
| 6. | ALA4603695 | B | Agonist activity at TLR7/8 in dog PBMC assessed as IFNgamma secretion at 20 uM after 29 hrs by ELISA (Rvb = 0.4 +/- 0.7 pg/ml) | Canis lupus familiaris | 13 | cell-based format | Scientific Literature | ||
| 7. | ALA4603699 | B | Agonist activity at TLR7/8 in dog PBMC assessed as maximal increase in TNFalpha secretion at 20 uM after 30 to 48 hrs by ELISA | Canis lupus familiaris | 13 | cell-based format | Scientific Literature | ||
| 8. | ALA4603700 | B | Agonist activity at TLR7/8 in dog PBMC assessed as maximal increase in IL-12 secretion at 20 uM after 30 to 48 hrs by ELISA | Canis lupus familiaris | 13 | cell-based format | Scientific Literature | ||
| 9. | ALA4603701 | B | Agonist activity at TLR7/8 in dog PBMC assessed as maximal increase in IFN-gamma secretion at 20 uM after 30 to 48 hrs by ELISA | Canis lupus familiaris | 13 | cell-based format | Scientific Literature | ||
| 10. | ALA4603702 | B | Agonist activity at TLR7/8 in dog PBMC assessed as increase in TNFalpha secretion at 20 uM measured over 24 hrs by ELISA | Canis lupus familiaris | 13 | cell-based format | Scientific Literature | ||
| 11. | ALA4603703 | B | Agonist activity at TLR7/8 in dog PBMC assessed as increase in IL-12 secretion at 20 uM measured over 24 hrs by ELISA | Canis lupus familiaris | 13 | cell-based format | Scientific Literature | ||
| 12. | ALA4603704 | B | Agonist activity at TLR7/8 in dog PBMC assessed as increase in IFN-gamma secretion at 20 uM measured over 24 hrs by ELISA | Canis lupus familiaris | 13 | cell-based format | Scientific Literature |
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