# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4260469 | Toxicity | Hepatotoxicity in human HepaRG cells assessed as GSH depletion at 500 uM after 3 to 12 hrs by ThiolTracker Violet dye-based fluorescence assay | Homo sapiens | 4 | ALA4257568 | cell-based format | Scientific Literature | |
2. | ALA4260470 | Toxicity | Hepatotoxicity in human HepaRG cells assessed as GSH depletion at 500 uM measured over 12 hrs by ThiolTracker Violet dye-based fluorescence assay | Homo sapiens | 4 | ALA4257568 | cell-based format | Scientific Literature | |
3. | ALA4260471 | Toxicity | Hepatotoxicity in human HepaRG cells assessed as GSH depletion at 1000 uM after 12 hrs by ThiolTracker Violet dye-based fluorescence assay | Homo sapiens | 4 | ALA4257568 | cell-based format | Scientific Literature | |
4. | ALA4260472 | Toxicity | Hepatotoxicity in human HepaRG cells assessed as necrotic cell death at 500 uM measured over 12 hrs by LDH assay | Homo sapiens | 4 | ALA4257568 | cell-based format | Scientific Literature | |
5. | ALA4260473 | Toxicity | Hepatotoxicity in human HepaRG cells assessed as necrotic cell death at 1000 uM measured over 12 hrs by LDH assay | Homo sapiens | 3 | ALA4257568 | cell-based format | Scientific Literature | |
6. | ALA4370369 | ADME | Cytotoxicity against human HepaRG cells assessed as cell viability at 100 uM after 24 hrs by CellTiter blue-reagent based assay relative to control | Homo sapiens | 4 | ALA4368915 | cell-based format | Scientific Literature | |
7. | ALA4413740 | ADME | Cytotoxicity in human HepaRG cells assessed as reduction in cell viability incubated for 14 days by CellTiter-Glo assay | Homo sapiens | 3 | ALA4411318 | cell-based format | Scientific Literature | |
8. | ALA4424040 | Toxicity | Hepatotoxicity in human HepaRG cells at 2.5 uM after 48 hrs | Homo sapiens | 2 | ALA4422646 | cell-based format | Scientific Literature | |
9. | ALA4621505 | Toxicity | Hepatotoxicity in human HepaRG cells assessed as decreased in ATP level treated 4 times during 14 days measured 16 hrs post-last dose by cell-titer glo assay | Homo sapiens | 3 | ALA4619775 | cell-based format | Scientific Literature | |
10. | ALA4621506 | Toxicity | Hepatotoxicity in human HepaRG cells assessed as decrease in glutathione level treated 4 times during 14 days measured 16 hrs post-last dose | Homo sapiens | 3 | ALA4619775 | cell-based format | Scientific Literature | |
11. | ALA4621507 | Toxicity | Hepatotoxicity in human HepaRG cells assessed as decreased in DNA structure treated 4 times during 14 days measured 16 hrs post-last dose | Homo sapiens | 3 | ALA4619775 | cell-based format | Scientific Literature | |
12. | ALA4621528 | Toxicity | Hepatotoxicity in human HepaRG cells assessed as increase in oxidative stress treated 4 times during 14 days measured 16 hrs post-last dose | Homo sapiens | 3 | ALA4619775 | cell-based format | Scientific Literature | |
13. | ALA4708301 | Toxicity | Hepatotoxicity in human HepaRG cells assessed as increase in lactate dehydrogenase release at 50 to 5000 uM measured after 6 to 24 hrs by fluorescence based analysis | Homo sapiens | 3 | ALA4706503 | cell-based format | Scientific Literature | |
14. | ALA4708302 | Toxicity | Hepatotoxicity in human HepaRG cells assessed as decrease in GSH level at 50 to 5000 uM measured after 6 to 24 hrs by Thiol tracker violet dye based fluorescence analysis | Homo sapiens | 3 | ALA4706503 | cell-based format | Scientific Literature | |
15. | ALA4730930 | ADME | Cytotoxicity against human HepaRG cells infected with HBV assessed as reduction in cell viability at 10 mM treated for 1 hr on day 5 post-infection followed by removal of media and supplemented with fresh media and further incubated for 3 days then followed by treatment for 1 hr on day 8 post-infection followed by removal of media and supplemented with fresh media and further incubated for 3 days in presence of 50 uM SKF-525A and measured on day 11 post-infection by Celltiter-Glo assay | Homo sapiens | 1 | ALA4725437 | cell-based format | Scientific Literature | |
16. | ALA4730931 | ADME | Cytotoxicity against human HepaRG cells infected with HBV assessed as reduction in cell viability at 50 uM treated for 1 hr on day 5 post-infection followed by removal of media and supplemented with fresh media and further incubated for 3 days then followed by treatment for 1 hr on day 8 post-infection followed by removal of media and supplemented with fresh media and further incubated for 3 days in presence of 10 mM ABT and measured on day 11 post-infection by Celltiter-Glo assay | Homo sapiens | 1 | ALA4725437 | cell-based format | Scientific Literature | |
17. | ALA4730963 | ADME | Cytotoxicity against human HepaRG cells infected with HBV assessed as reduction in cell viability at 5 to 100 uM treated for 1 hr on day 5 post-infection followed by removal of media and supplemented with fresh media and further incubated for 3 days then followed by treatment for 1 hr on day 8 post-infection followed by removal of media and supplemented with fresh media and further incubated for 3 days and measured on day 11 post-infection by Celltiter-Glo assay | Homo sapiens | 1 | ALA4725437 | cell-based format | Scientific Literature | |
18. | ALA4730965 | ADME | Cytotoxicity against human HepaRG cells infected with HBV assessed as reduction in cell viability at 0.2 to 20 mM treated for 1 hr on day 5 post-infection followed by removal of media and supplemented with fresh media and further incubated for 3 days then followed by treatment for 1 hr on day 8 post-infection followed by removal of media and supplemented with fresh media and further incubated for 3 days and measured on day 11 post-infection by Celltiter-Glo assay | Homo sapiens | 1 | ALA4725437 | cell-based format | Scientific Literature | |
19. | ALA4730983 | ADME | Cytotoxicity against human HepaRG cells assessed as effect on cell viability | Homo sapiens | 4 | ALA4725437 | cell-based format | Scientific Literature | |
20. | ALA4769929 | ADME | Cytotoxicity against human HepaRG assessed as reduction in cell viability at 100 uM incubated for 24 hrs by Cell-Titer Glo assay | Homo sapiens | 1 | ALA4765317 | cell-based format | Scientific Literature |