| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4628096 | B | Inhibition of AIM2 inflammasome (unknown origin) activation in bone marrow derived macrophages assessed as inhibition of poly(dA:dT)-induced IL-1beta secretion at 5 uM by ELISA | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 2. | ALA4671761 | B | Inhibition of AIM2 inflammasome (unknown origin) | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 3. | ALA4775314 | B | Inhibition of AIM2 in PMA-stimulated human THP-1 cells transfected with poly(dA:dT) assessed as reduction in IL-1beta production at 5 to 15 uM pre-treated for 24 hrs followed by stimulation with LPS for 4 hrs by ELISA analysis | Homo sapiens | 1 | tissue-based format | Scientific Literature | ||
| 4. | ALA5038476 | B | Inhibition of AIM2 inflammasome activation in LPS-induced human THP-1 cells at 1 uM for 40 mins followed by flagellin stimulation for 6 h by ELISA | Homo sapiens | 1 | tissue-based format | Scientific Literature | ||
| 5. | ALA5038478 | B | Inhibition of AIM2 inflammasome activation in LPS-induced human THP-1 cells at 3 to 5uM for 40 mins followed by flagellin stimulation for 6 h by ELISA | Homo sapiens | 1 | tissue-based format | Scientific Literature | ||
| 6. | ALA5138370 | B | Inhibition of AIM2 inflammasome activation in LPS-primed human THP-1 cells assessed as attenuation of ASC oligomerization at 0.1 to 10 uM preincubated for 30 mins followed by overnight stimulation with poly(dA:dT) by western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 7. | ALA5138371 | B | Inhibition of NLRP3 inflammasome activation in LPS-primed human THP-1 ASC knock out cells reconstituted with mouse ASC assessed as inhibition of IL-1beta release at 0.1 to 10 uM preincubated for 30 mins followed by nigericin stimulation and measured after 30 mins by ELISA | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 8. | ALA5138391 | B | Inhibition of AIM2 inflammasome activation in LPS-primed human THP-1 cells assessed as reduction in IL-1beta release in cell supernatant at 0.1 to 10 uM pretreated for 30 mins followed by poly(dA:dT) stimulation and measured after 4 hrs by ELISA | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 9. | ALA5138392 | B | Inhibition of AIM2 inflammasome activation in LPS-primed human THP-1 cells assessed as reduction in IL-1beta release at 0.1 to 10 uM pretreated for 30 mins followed by poly(dA:dT) stimulation and measured after 4 hrs by western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 10. | ALA5138393 | B | Inhibition of AIM2 inflammasome activation in LPS-primed human THP-1 cells assessed as activation of caspase-1 at 0.1 to 10 uM pretreated for 30 mins followed by poly(dA:dT) stimulation and measured after 4 hrs by western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 11. | ALA5138424 | B | Inhibition of AIM2 inflammasome activation in LPS-primed human THP-1 cells assessed as increase in JNK phosphorylation at 10 uM preincubated for 30 mins followed by overnight stimulation with poly(dA:dT) by western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 12. | ALA5138428 | B | Inhibition of AIM2 inflammasome activation in LPS-primed human HEK-293T assessed as AIM2-ASC interaction by co-immunoprecipitation assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 13. | ALA5138429 | B | Inhibition of AIM2 inflammasome activation in LPS-primed human HEK-293T assessed as AIM2-AIM2 interaction by co-immunoprecipitation assay | Homo sapiens | 1 | cell-based format | Scientific Literature |
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