# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4628095 | Binding | Inhibition of NLRC4 inflammasome (unknown origin) activation in bone marrow derived macrophages assessed as inhibition of Salmonella-induced IL-1beta secretion at 5 uM by ELISA | Homo sapiens | 1 | ALA4627283 | single protein format | Scientific Literature | |
2. | ALA4775313 | Binding | Inhibition of NLRC4 in PMA-stimulated human THP-1 cells assessed as reduction in IL-1beta production at 5 to 15 uM pre-treated for 24 hrs followed by stimulation with LPS for 3 hrs and Salmonella typhimurium flagellin for 1 hr by ELISA analysis | Homo sapiens | 1 | ALA4765468 | tissue-based format | Scientific Literature | |
3. | ALA5038475 | Binding | Inhibition of NLRC4 inflammasome activation in LPS-induced human THP-1 cells at 1 uM for 40 mins followed by flagellin stimulation for 6 h by ELISA | Homo sapiens | 1 | ALA5036380 | tissue-based format | Scientific Literature | |
4. | ALA5038477 | Binding | Inhibition of NLRC4 inflammasome activation in LPS-induced human THP-1 cells at 3 to 5uM for 40 mins followed by flagellin stimulation for 6 h by ELISA | Homo sapiens | 1 | ALA5036380 | tissue-based format | Scientific Literature | |
5. | ALA5138394 | Binding | Inhibition of NLRC4 inflammasome activation in LPS-primed human THP-1 cells infected in salmonella typhimurium assessed as reduction in IL-1beta release in cell supernatant at 0.1 to 10 uM for 30 mins followed by Salmonella infection and measured after 3.5 hrs by ELISA | Homo sapiens | 1 | ALA5137000 | cell-based format | Scientific Literature | |
6. | ALA5138395 | Binding | Inhibition of NLRC4 inflammasome activation in LPS-primed human THP-1 cells infected in salmonella typhimurium assessed as reduction in IL-1beta release at 0.1 to 10 uM for 30 mins followed by Salmonella infection and measured after 3.5 hrs by western blot analysis | Homo sapiens | 1 | ALA5137000 | cell-based format | Scientific Literature | |
7. | ALA5138396 | Binding | Inhibition of NLRC4 inflammasome activation in LPS-primed human THP-1 cells infected in salmonella typhimurium assessed as reduction in caspase-1 activation at 0.1 to 10 uM for 30 mins followed by Salmonella infection and measured after 3.5 hrs by western blot analysis | Homo sapiens | 1 | ALA5137000 | cell-based format | Scientific Literature | |
8. | ALA5217834 | Binding | Inhibition of NLRC4 inflammasome activation in LPS/flagellin-treated human THP-1 cells preincubated with LPS for 3 hrs followed by compound addition for 30 mins and further stimulated with flagellin for 90 min | Homo sapiens | 1 | ALA5214989 | cell-based format | Scientific Literature |