| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4630260 | B | Inhibition of human recombinant-Sialin expressed in HEK293 cells assessed as reduction in [3H]Neu5Ac uptake at 30 to 300 uM incubated for 15 mins by liquid scintillation counting method | Homo sapiens | 15 | cell-based format | Scientific Literature | ||
| 2. | ALA4630261 | B | Inhibition of human recombinant-Sialin expressed in HEK293 cells assessed as reduction in [3H]Neu5Ac uptake at 30 uM incubated for 15 mins by liquid scintillation counting method | Homo sapiens | 25 | cell-based format | Scientific Literature | ||
| 3. | ALA4630262 | B | Ratio of Km for Neu5Ac to Ic50 for test compound for inhibition of human recombinant-Sialin expressed in HEK293 cells assessed as reduction in [3H]Neu5Ac uptake at 30 to 300 uM incubated for 15 mins by liquid scintillation counting method | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 4. | ALA4630267 | B | Inhibition of human recombinant-Sialin expressed in HEK293 cells assessed as reduction in [3H]Neu5Ac uptake at 100 uM incubated for 15 mins by liquid scintillation counting method | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 5. | ALA4630271 | B | Non-competitive inhibition of human recombinant-Sialin expressed in HEK293 cells assessed as reduction in Vmax for [3H]Neu5Ac uptake at 10 uM incubated for 15 mins by liquid scintillation counting method relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 6. | ALA4630272 | B | Non-competitive inhibition of human recombinant-Sialin expressed in HEK293 cells assessed as reduction in [3H]Neu5Ac uptake by measuring Km level at 10 uM incubated for 15 mins by liquid scintillation counting method (Rvb = 1.6 +/- 0.3 mM) | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 7. | ALA4630273 | B | Non-competitive inhibition of human recombinant-Sialin expressed in HEK293 cells assessed as reduction in Vmax for [3H]Neu5Ac uptake at 3 uM incubated for 15 mins by liquid scintillation counting method relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 8. | ALA4630274 | B | Non-competitive inhibition of human recombinant-Sialin expressed in HEK293 cells assessed as reduction in [3H]Neu5Ac uptake by measuring Km level at 3 uM incubated for 15 mins by liquid scintillation counting method (Rvb = 1.6 +/- 0.3 mM) | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 9. | ALA4630275 | B | Non-competitive inhibition of human recombinant-Sialin expressed in HEK293 cells assessed as reduction in [3H]Neu5Ac uptake incubated for 15 mins by liquid scintillation counting method | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 10. | ALA4630276 | B | Trans-stimulation of human recombinant-Sialin expressed in HEK293 cells assessed as [3H]Neu5Ac transport at 5 mM pre-incubated for 15 mins at pH 5.5 followed by 15 or 30 mins wash at pH 7 at room temperature by liquid scintillation counting method | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 11. | ALA4630277 | B | Inhibition of human recombinant-Sialin expressed in HEK293 cells assessed as reduction in [3H]Neu5Ac transport at 120 uM pre-incubated for 15 mins at pH 5.5 followed by 15 or 30 mins wash at pH 7 at room temperature by liquid scintillation counting method relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 12. | ALA4630278 | B | Inhibition of human recombinant-Sialin expressed in HEK293 cells assessed as reduction in [3H]Neu5Ac transport at 12 uM pre-incubated for 15 mins at pH 5.5 followed by 15 or 30 mins wash at pH 7 at room temperature by liquid scintillation counting method relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 13. | ALA4630279 | B | Inhibition of human recombinant-Sialin expressed in HEK293 cells assessed as reduction in [3H]Neu5Ac transport pre-incubated for 15 mins at pH 5.5 followed by 15 mins wash at pH 7 at room temperature by liquid scintillation counting method relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 14. | ALA4630284 | B | Inhibition of cellular distribution of EGFP-tagged human Sialin expressed in human HeLa cells assessed as lysosomal distribution level at 72 uM by LAMP1 immunostaining based fluorescence microscopy | Homo sapiens | 1 | cell-based format | Scientific Literature |
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