| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4669279 | B | Inhibition of SPHK1/SPHK2 in human HL-60 cells assessed as sphingosine level assessed per 10^6 cells at 5 uM after 24 hrs by LC-ESI/MS analysis (Rvb = 18.3 +/- 3.5 pmol) | Homo sapiens | 1 | ALA4665719 | cell-based format | Scientific Literature | |
| 2. | ALA4669280 | B | Inhibition of SPHK1/SPHK2 in human HL-60 cells assessed as sphingosine-1-phosphate level assessed per 10^6 cells at 5 uM after 24 hrs by LC-ESI/MS analysis (Rvb = 3.1 +/- 0.3 pmol) | Homo sapiens | 1 | ALA4665719 | cell-based format | Scientific Literature | |
| 3. | ALA4669281 | B | Inhibition of SPHK1/SPHK2 in human HL-60 cells assessed as C16:0 ceramide level assessed per 10^6 cells at 5 uM after 24 hrs by LC-ESI/MS analysis (Rvb = 33.5 +/- 4.1 pmol) | Homo sapiens | 1 | ALA4665719 | cell-based format | Scientific Literature | |
| 4. | ALA4669282 | B | Inhibition of SPHK1/SPHK2 in human HL-60 cells assessed as C18:0 ceramide level assessed per 10^6 cells at 5 uM after 24 hrs by LC-ESI/MS analysis (Rvb = 1.6 +/- 0.2 pmol) | Homo sapiens | 1 | ALA4665719 | cell-based format | Scientific Literature | |
| 5. | ALA4669283 | B | Inhibition of SPHK1/SPHK2 in human HL-60 cells assessed as sphingosine level assessed per 10^6 cells at 500 nM after 24 hrs by LC-ESI/MS analysis (Rvb = 18.3 +/- 3.5 pmol) | Homo sapiens | 1 | ALA4665719 | cell-based format | Scientific Literature | |
| 6. | ALA4669284 | B | Inhibition of SPHK1/SPHK2 in human HL-60 cells assessed as sphingosine-1-phosphate level assessed per 10^6 cells at 500 nM after 24 hrs by LC-ESI/MS analysis (Rvb = 3.1 +/- 0.3 pmol) | Homo sapiens | 1 | ALA4665719 | cell-based format | Scientific Literature | |
| 7. | ALA4669285 | B | Inhibition of SPHK1/SPHK2 in human HL-60 cells assessed as C16:0 ceramide level assessed per 10^6 cells at 500 nM after 24 hrs by LC-ESI/MS analysis (Rvb = 33.5 +/- 4.1 pmol) | Homo sapiens | 1 | ALA4665719 | cell-based format | Scientific Literature | |
| 8. | ALA4669286 | B | Inhibition of SPHK1/SPHK2 in human HL-60 cells assessed as C18:0 ceramide level assessed per 10^6 cells at 500 nM after 24 hrs by LC-ESI/MS analysis (Rvb = 1.6 +/- 0.2 pmol) | Homo sapiens | 1 | ALA4665719 | cell-based format | Scientific Literature | |
| 9. | ALA4669297 | B | Inhibition of SPHK1/SPHK2 in human HL-60 cells assessed as induction of apoptosis by measuring spindle assembly checkpoint arrest at 20 uM after 16 hrs in presence of ispinesib by Western blot analysis | Homo sapiens | 1 | ALA4665719 | cell-based format | Scientific Literature | |
| 10. | ALA4669298 | B | Inhibition of SPHK1/SPHK2 in human HL-60 cells assessed as induction of apoptosis by measuring spindle assembly checkpoint arrest at 20 uM after 16 hrs in presence of volasertib by Western blot analysis | Homo sapiens | 1 | ALA4665719 | cell-based format | Scientific Literature | |
| 11. | ALA4669299 | B | Inhibition of SPHK1/SPHK2 in human HL-60 cells assessed as induction of apoptosis by measuring spindle assembly checkpoint arrest at 20 uM after 16 hrs in presence of combretastatin A4 by Western blot analysis | Homo sapiens | 1 | ALA4665719 | cell-based format | Scientific Literature | |
| 12. | ALA4669300 | B | Inhibition of SPHK1/SPHK2 in human HL-60 cells assessed as induction of apoptosis by measuring spindle assembly checkpoint arrest at 3 nM after 16 hrs by Western blot analysis | Homo sapiens | 1 | ALA4665719 | cell-based format | Scientific Literature | |
| 13. | ALA4669301 | B | Inhibition of SPHK1/SPHK2 in human HL-60 cells assessed as induction of apoptosis by measuring spindle assembly checkpoint arrest at 20 nM after 16 hrs by Western blot analysis | Homo sapiens | 1 | ALA4665719 | cell-based format | Scientific Literature | |
| 14. | ALA4669302 | B | Inhibition of SPHK1/SPHK2 in human HL-60 cells assessed as induction of apoptosis by measuring spindle assembly checkpoint arrest at 1 uM after 16 hrs by Western blot analysis | Homo sapiens | 1 | ALA4665719 | cell-based format | Scientific Literature | |
| 15. | ALA4672286 | A | Prodrug conversion in human blood assessed as SPHK1/SPHK2-mediated compound phosphorylation by measuring intrinsic clearance by LC-MS/MS analysis | Homo sapiens | 4 | ALA4665867 | tissue-based format | Scientific Literature | |
| 16. | ALA4672287 | A | Prodrug conversion in human blood assessed as SPHK1/SPHK2-mediated compound phosphorylation by measuring Vmax by LC-MS/MS analysis | Homo sapiens | 4 | ALA4665867 | tissue-based format | Scientific Literature | |
| 17. | ALA4672288 | A | Prodrug conversion in human blood assessed as SPHK1/SPHK2-mediated compound phosphorylation by measuring Km by LC-MS/MS analysis | Homo sapiens | 4 | ALA4665867 | tissue-based format | Scientific Literature | |
| 18. | ALA4689039 | B | Inhibition of SphK1/SphK2 in human U-937 cells assessed as reduction in S1P production measured after 2 hrs by LC-MS/MS analysis | Homo sapiens | 1 | ALA4680333 | cell-based format | Scientific Literature | |
| 19. | ALA4736177 | B | Inhibition of Sphk1/Sphk2 in human U-937 cells assessed as reduction in S1P level measured after 2 hrs by LC-MS analysis | Homo sapiens | 1 | ALA4732143 | cell-based format | Scientific Literature |
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