| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5256457 | B | PROTAC activity at CRBN/H-PGDS in human KU812 cells assessed as induction of H-PGDS degradation by measuring decrease in H-PGDS protein expression incubated for 24 hrs by western blot analysis | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
| 2. | ALA4679882 | B | Induction of CRBN-mediated HPGDS degradation in human KU812 cells at 10 to 100 nM incubated for 24 hrs followed by compound washout and further incubated for 6 hrs in compound-free medium by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 3. | ALA4679883 | B | Protac activity at CRBN/HPGDS in human KU812 cells assessed as induction of HPGDS degradation at 10 to 100 nM incubated for 24 hrs followed by compound washout and further incubated for 6 hrs in compound-free medium by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 4. | ALA4679886 | B | Protac activity at CRBN/HPGDS in human KU812 cells assessed as induction of HPGDS degradation at 100 nM measured after 6 hrs in presence of ubiquitin-activating enzyme inhibitor MLN7243 by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 5. | ALA4679887 | B | Protac activity at CRBN/HPGDS in human KU812 cells assessed as induction of HPGDS degradation at 100 nM measured after 6 hrs in presence of proteasome inhibitor MG132 by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 6. | ALA4679888 | B | Competitive binding affinity to HPGDS in human KU812 cells assessed as induction of CRBN-mediated degradation of HPGDS at 100 nM after 6 hrs in presence of excess pomalidomide by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 7. | ALA4679891 | B | Protac activity at CRBN/HPGDS in human KU812 cells assessed as induction of HPGDS degradation at 1 uM measured after 6 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 8. | ALA4679894 | B | Protac activity at CRBN/HPGDS in human KU812 cells assessed as decrease in HPGDS protein level by measuring protein turnover at 100 nM measured within 6 hrs in presence of protein synthesis inhibitor cycloheximide by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 9. | ALA4679898 | B | Protac activity at CRBN/HPGDS in human MEG01s cells assessed as reduction in HPGDS protein level up to 1000 nM measured after 6 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 10. | ALA4679901 | B | Protac activity at CRBN/HPGDS in human KU812 cells assessed as reduction in HPGDS protein level at >=10 nM measured after 3 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 11. | ALA4679902 | B | Protac activity at CRBN/HPGDS in human KU812 cells assessed as reduction in HPGDS protein level at 100 to 1000 nM measured after 3 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 12. | ALA4679903 | B | Protac activity at CRBN/HPGDS in human KU812 cells assessed as reduction in HPGDS protein level at >=10 nM measured after 6 to 24 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 13. | ALA5057131 | B | PROTAC activity at H-PGDS/CRBN in human KU812 cells assessed as H-PGDS degradation measured after 6 hrs by Western blot analysis | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 14. | ALA5057132 | B | PROTAC activity at H-PGDS/CRBN in human KU812 cells assessed as H-PGDS degradation measured after 24 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 15. | ALA5057133 | B | PROTAC activity at H-PGDS/CRBN in human MEG01s cells assessed as H-PGDS degradation measured after 6 to 24 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 16. | ALA5057136 | B | PROTAC activity at H-PGDS/CRBN in human KU812 cells assessed as H-PGDS degradation in presence of pomalidomide measured after 6 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 17. | ALA5057137 | B | PROTAC activity at H-PGDS/CRBN in human KU812 cells assessed as H-PGDS degradation in presence of MG132 at 100 pM measured after 6 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 18. | ALA5057138 | B | PROTAC activity at H-PGDS/CRBN in human KU812 cells assessed as H-PGDS degradation in presence of MLN7243 at 100 pM measured after 6 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 19. | ALA5057139 | B | PROTAC activity at H-PGDS/CRBN in human KU812 cells assessed as reduction in H-PGDS level at 100 pM measured after 6 hrs by Western blot analysis relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 20. | ALA5057140 | B | PROTAC activity at H-PGDS/CRBN in human KU812 cells assessed as reduction in H-PGDS level at 10 pM measured after 6 hrs by Western blot analysis relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature |
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