# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4709788 | B | Binding affinity to METTL3 (unknown origin) | Homo sapiens | 1 | single protein format | Scientific Literature | ||
2. | ALA4827621 | B | Inhibition of METTL3 (unknown origin) using 3' biotinylated RNA (UCUGGACUAAA) and 3H-SAM as a substrate preincubated for 5 mins followed by substrate addition incubated for 30 mins by scintillation counting method | Homo sapiens | 6 | single protein format | Scientific Literature | ||
3. | ALA4827622 | B | Inhibition of METTL3-mediated m6A methylation in human MOLM-3 cells assessed as reduction in mRNA level measured after 24 hrs by LC-MS/MS analysis | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
4. | ALA5051761 | B | Inhibition of METTL3 (unknown origin) using UCUGGACUAAA-biotin and 3H-SAM as substrates preincubated for 5 mins followed by substrate addition incubated for 30 mins by TopCount scintillation counting method | Homo sapiens | 222 | single protein format | Patent Bioactivity Data | ||
5. | ALA5051765 | B | Inhibition of METTL3-mediated m6A methylation in human MOLM-13 cells assessed as reduction in mRNA level measured after 24 hrs by LC-MS/MS analysis | Homo sapiens | 50 | cell-based format | Patent Bioactivity Data | ||
6. | ALA5053379 | B | Inhibition of METTL3-mediated m6A methylation in human MOLM-13 cells assessed as reduction in mRNA level measured after 24 hrs by LC-MS/MS analysis | Homo sapiens | 51 | cell-based format | Patent Bioactivity Data | ||
7. | ALA5053383 | B | Inhibition of METTL3 (unknown origin) using UCUGGACUAAA-biotin and 3H-SAM as substrates preincubated for 5 mins followed by substrate addition incubated for 30 mins by TopCount scintillation counting method | Homo sapiens | 237 | single protein format | Patent Bioactivity Data | ||
8. | ALA5053965 | B | Inhibition of recombinant METLL3 (unknown origin) expressed in baculovirus infected Sf9 cells assessed as decrease in N6-methyladenosine level in oligonucleotide substrate by TR-FRET assay | Homo sapiens | 23 | cell-based format | Scientific Literature | ||
9. | ALA5053975 | B | Thermal stabilization of recombinant METTL3 (354 to 580 residues) (unknown origin) expressed in HEK293T cells assessed as non-aggregated METTL3-ePL protein incubated for 1 hr and cells heated 46 degC by luminescence-based InCELL Pulse assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
10. | ALA5053976 | B | Thermal stabilization of endogenously expressing full length METTL3 in human MOLM-13 cells assessed as stabilized METTL3 incubated for at 54 degC by Western blotting based CETSA assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
11. | ALA5243055 | B | Inhibition of METTL3 (unknown origin) assessed as remaining activity at 500 uM relative to control | Homo sapiens | 6 | single protein format | Scientific Literature | ||
12. | ALA5243056 | B | Inhibition of METTL3 (unknown origin) | Homo sapiens | 11 | single protein format | Scientific Literature | ||
13. | ALA5243061 | B | Inhibition of METTL3 in human MOLM-13 cells assessed as reduction in m6A methylation level | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
14. | ALA5243062 | B | Binding affinity to METTL3 (unknown origin) by SPR method | Homo sapiens | 1 | single protein format | Scientific Literature |