# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4702091 | B | Protac activity at VHL/PARP1 in human MDA-MB-436 cells assessed as reduction in PARP1 protein level at 1 uM incubated for 24 hrs by western blot analysis | Homo sapiens | 4 | ALA4699498 | cell-based format | Scientific Literature | |
2. | ALA4702092 | B | Protac activity at VHL/PARP1 in human MDA-MB-436 cells assessed as reduction in PARP1 protein level at 0.01 to 10 uM incubated for 12 hrs by western blot analysis | Homo sapiens | 2 | ALA4699498 | cell-based format | Scientific Literature | |
3. | ALA4702093 | B | Protac activity at VHL/PARP1 in human SW620 cells assessed as reduction in PARP1 protein level at 0.01 to 10 uM incubated for 12 hrs by western blot analysis | Homo sapiens | 2 | ALA4699498 | cell-based format | Scientific Literature | |
4. | ALA4702094 | B | Protac activity at VHL/PARP1 in human MDA-MB-436 cells assessed as PARP1 protein degradation at 1 to 10 nM incubated for 24 hrs by western blot analysis | Homo sapiens | 1 | ALA4699498 | cell-based format | Scientific Literature | |
5. | ALA4702095 | B | Protac activity at VHL/PARP1 in human Capan1 cells assessed as PARP1 protein degradation at 1 to 10 nM incubated for 24 hrs by western blot analysis | Homo sapiens | 1 | ALA4699498 | cell-based format | Scientific Literature | |
6. | ALA5039975 | B | Protac activity at VHL/PARP-1 in human NCI-H1299 cells assessed as induction of PARP degradation at up to 15 uM incubated for 36 hrs by Western blot analysis | Homo sapiens | 8 | ALA5038593 | cell-based format | Scientific Literature | |
7. | ALA5039976 | B | Protac activity at VHL/PARP-1 in human NCI-H1299 cells assessed as induction of EGFR degradation at 0.47 uM incubated for 36 hrs by Western blot analysis relative to control | Homo sapiens | 1 | ALA5038593 | cell-based format | Scientific Literature | |
8. | ALA5039978 | B | Protac activity at VHL/PARP-1 in human A-431 cells assessed as induction of PARP-1 degradation at 0.8 to 20 uM incubated for 36 hrs by Western blot analysis | Homo sapiens | 1 | ALA5038593 | cell-based format | Scientific Literature | |
9. | ALA5039981 | B | Protac activity at VHL/PARP-1 in human NCI-H1299 cells assessed as induction of PARP degradation at 4 uM incubated for 6 hrs by Western blot analysis | Homo sapiens | 1 | ALA5038593 | cell-based format | Scientific Literature |